Patents by Inventor Nicolaas Smit
Nicolaas Smit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952614Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: GrantFiled: January 13, 2021Date of Patent: April 9, 2024Assignee: Safeguard Biosystems Holdings Ltd.Inventors: Holger Klapproth, Nicolaas Smit
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Publication number: 20230383242Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: ApplicationFiled: April 21, 2023Publication date: November 30, 2023Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.Inventors: Holger KLAPPROTH, Nicolaas SMIT
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Patent number: 11667884Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: GrantFiled: January 29, 2018Date of Patent: June 6, 2023Assignee: Safeguard Biosystems Holdings Ltd.Inventors: Holger Klapproth, Nicolaas Smit
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Publication number: 20210284951Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: ApplicationFiled: January 29, 2018Publication date: September 16, 2021Applicant: Safeguard Biosystems Holdings Ltd.Inventors: Holger KLAPPROTH, Nicolaas SMIT
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Publication number: 20210139952Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: ApplicationFiled: January 13, 2021Publication date: May 13, 2021Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.Inventors: Holger Klapproth, Nicolaas Smit
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Publication number: 20200308629Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.Type: ApplicationFiled: November 21, 2018Publication date: October 1, 2020Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.Inventors: Nicolaas SMIT, Sonja BEDNAR, Holger KLAPPROTH, Kevin BOYNTON
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Patent number: 10513730Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.Type: GrantFiled: November 22, 2017Date of Patent: December 24, 2019Assignee: Safeguard Biosystems Holdings Ltd.Inventors: Nicolaas Smit, Sonja Bednar, Holger Klapproth, Kevin Boynton
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Publication number: 20190153508Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.Type: ApplicationFiled: November 22, 2017Publication date: May 23, 2019Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.Inventors: Nicolaas SMIT, Sonja BEDNAR, Holger KLAPPROTH, Kevin BOYNTON
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Publication number: 20180305740Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: ApplicationFiled: June 29, 2018Publication date: October 25, 2018Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.Inventors: Holger KLAPPROTH, Nicolaas SMIT
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Patent number: 10036054Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: GrantFiled: February 14, 2017Date of Patent: July 31, 2018Assignee: Safeguard Biosystems Holdings Ltd.Inventors: Holger Klapproth, Nicolaas Smit
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Publication number: 20170218356Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.Type: ApplicationFiled: February 14, 2017Publication date: August 3, 2017Applicant: Safeguard Biosystems Holdings Ltd.Inventors: Holger KLAPPROTH, Nicolaas SMIT
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Publication number: 20100223862Abstract: This anchoring system is specifically designed to be used in soft, sandy-like earth to anchor a variety of objects, including recovering of 4×4 vehicles stuck in sand or soft material, that need to be winched out without having a fixed object to anchor it to. In other words no fixed object like a tree or a pole, or another vehicle, is necessary to attach the anchor to. This anchoring system can easily be used by one person. What differentiates this auger from other kinds of augers is that the point of strength is underground and connected to a cable. If the cable is pulled it provides the anchor point to which a tensile load can be applied in a direction oblique to the longitudinal axis of the auger. It can be used in a variety of applications, like anchoring tents and poles, and recovering vehicles etc.Type: ApplicationFiled: March 6, 2009Publication date: September 9, 2010Inventor: Jacobus Nicolaas Smit
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Patent number: 7074610Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: August 30, 2001Date of Patent: July 11, 2006Assignee: i-Stat CorporationInventors: Stephen N. Cozzette, Graham Davis, Jeanne A. Itak, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Susan J. Steiner, Paul Van Der Werf, Henry J. Wieck
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Publication number: 20020090738Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: ApplicationFiled: August 30, 2001Publication date: July 11, 2002Applicant: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck
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Patent number: 6306594Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: November 17, 1998Date of Patent: October 23, 2001Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van der Werf, Henry J. Wieck
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Patent number: 5837454Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, deceased, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck, Susan Steiner, Jeanne Itak
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Patent number: 5837446Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over he dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: i-STAT CorporationInventors: Stephen N. Cozzette, Graham Davis, Jeanne Itak, Imants R. Lauks, Sylvia Piznik, Nicolaas Smit, Susan Steiner, Paul Van Der Werf, Henry J. Wieck, Randall M. Mier, deceased
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Patent number: 5554339Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: August 19, 1993Date of Patent: September 10, 1996Assignee: i-Stat CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck
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Patent number: 5466575Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: September 10, 1992Date of Patent: November 14, 1995Assignee: i-Stat CorporationInventors: Stephen N. Cozzette, Graham Davis, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Paul Van Der Werf, Henry J. Wieck
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Patent number: 5200051Abstract: An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments.Type: GrantFiled: November 7, 1989Date of Patent: April 6, 1993Assignee: I-Stat CorporationInventors: Stephen N. Cozzette, Graham Davis, Jeanne A. Itak, Imants R. Lauks, Randall M. Mier, Sylvia Piznik, Nicolaas Smit, Susan J. Steiner, Paul Van Der Werf, Henry J. Wieck