Patents by Inventor Nicole Dusch

Nicole Dusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200216867
    Abstract: The invention provides a method of producing L-tryptophan, the method comprising culturing a L-tryptophan producing microorganism belonging to the Enterobacteriaceae family in a fermentation medium; wherein the L-tryptophan producing microorganism has been modified by enhancing the expression level of the mdfA gene or by enhancing the expression level of an mdfA allele.
    Type: Application
    Filed: January 5, 2020
    Publication date: July 9, 2020
    Inventors: Mechthild Rieping, Silke Jerrentrup, Nicole Dusch
  • Patent number: 8883458
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the yjcG-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: November 11, 2014
    Assignee: Evonik Degussa GmbH
    Inventor: Nicole Dusch
  • Publication number: 20110053227
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the yjcG-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.
    Type: Application
    Filed: January 22, 2010
    Publication date: March 3, 2011
    Inventor: Nicole DUSCH
  • Patent number: 7575905
    Abstract: The invention relates to a process for the preparation of L-amino acids by the fermentation of recombinant microorganisms of the family Enterobacteriaceae. The microorganisms produce the desired L-amino acid and overexpress the E. coli or S. typhimurium yibD gene encoding the putative glycosyl transferase enzyme. The microorganisms are cultivated in a medium under conditions in which the desired L-amino acid is enriched in the medium or in the cells. The amino acid is then isolated, optionally with constituents of the fermentation broth, and/or all or part (?0 to 100%) of the biomass.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: August 18, 2009
    Assignee: Evonik Degussa GmbH
    Inventors: Mechthild Rieping, Nicole Dusch
  • Patent number: 7553645
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family in which the ytfQ-ORF is overexpressed.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: June 30, 2009
    Assignee: Evonik Degussa GmbH
    Inventor: Nicole Dusch
  • Publication number: 20060286644
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the ytfQ-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.
    Type: Application
    Filed: May 2, 2006
    Publication date: December 21, 2006
    Applicant: Degussa AG
    Inventor: Nicole Dusch
  • Publication number: 20060257979
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the yjcG-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium under conditions under which the desired L-amino acid is accumulated in the medium or in the cells, and b) the desired L-amino acid is isolated, with, where appropriate, constituents of the fermentation broth, and/or the biomass remaining in its/their entirety or in portions (from ?0 to 100%) in the isolated product or being removed completely.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 16, 2006
    Applicant: Degussa AG.
    Inventor: Nicole Dusch
  • Publication number: 20050196848
    Abstract: An isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide which contains an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b) and d) polynucleotide containing at least 15 successive bases of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids by attenuation of the poxB gene.
    Type: Application
    Filed: April 22, 2005
    Publication date: September 8, 2005
    Inventors: Nicole Dusch, Brigitte Bathe, Jorn Kalinowski, Alfred Puhler, Bettina Mockel, Anke Weissenborn, Walter Pfefferle
  • Publication number: 20050153403
    Abstract: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family. The microorganisms are characterized by the overexpression or enhancement of the yaaU ORF. The desired L-amino acid is isolated, with, optionally, constituents of the fermentation broth, and/or the biomass remaining in the isolated product.
    Type: Application
    Filed: December 21, 2004
    Publication date: July 14, 2005
    Inventor: Nicole Dusch
  • Patent number: 6911329
    Abstract: The invention relates to a process for preparing D-pantothenic acid using Coryneform bacteria in which the poxB gene is attenuated.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: June 28, 2005
    Assignee: Degussa AG
    Inventors: Nicole Dusch, Hermann Thomas, Georg Thierbach
  • Patent number: 6787334
    Abstract: The invention relates to a process for the preparation and improvement of D-pantothenic acid-producing microorganisms by amplification of nucleotide sequences which code for ketopantoate reductase, in particular the panE gene, individually or in combination with one another, and optionally additionally of the ilvC gene, the microorganisms containing these nucleotide sequences, and a process for the preparation of D-pantothenic acid comprising fermentation of these microorganisms, concentration of pantothenic acid in the medium or in the cells of the microorganisms, and isolation of the D-pantothenic acid.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: September 7, 2004
    Assignee: Degussa AG
    Inventors: Frank Elischweski, Jorn Kalinowski, Alfred Puhler, Nicole Dusch, Jurgen Dohmen, Mike Farwick, Georg Thierbach
  • Patent number: 6692946
    Abstract: The present invention relates to polynucleotides corresponding to the nadA gene and which encode the quinolinate synthetase A protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having quinolinate synthetase A activity.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: February 17, 2004
    Assignee: Degussa AG
    Inventors: Christine Bastuck, Brigitte Bathe, Nicole Dusch, Bettina Moeckel, Georg Thierbach
  • Patent number: 6689587
    Abstract: The present invention relates to polynucleotides corresponding to the nadC gene and which encode the nicotinate nucleotide pyrophosphorylase protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having nicotinate nucleotide pyrophosphorylase activity.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: February 10, 2004
    Assignee: Degussa AG
    Inventors: Christine Bastuck, Brigitte Bathe, Nicole Dusch, Bettina Moeckel, Georg Thierbach
  • Patent number: 6667166
    Abstract: The present invention provides processes for preparing D-pantothenic acid using Coryneform bacteria having an enhanced pfkA gene.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: December 23, 2003
    Assignee: Degussa AG
    Inventors: Georg Thierbach, Nicole Dusch
  • Publication number: 20020176884
    Abstract: The invention provides a process for the fermentative preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of coryneform bacteria, in particular those which already produce D-pantothenic acid, wherein the nucleotide sequence(s) in the coryneform bacteria which code(s) for the glyA gene is (are) enhanced, in particular over-expressed.
    Type: Application
    Filed: October 23, 2001
    Publication date: November 28, 2002
    Applicant: Degussa AG
    Inventors: Nicole Dusch, Achim Marx, Walter Pfefferle, Georg Thierbach
  • Publication number: 20020150999
    Abstract: The invention relates to a process for preparing D-pantothenic acid using Coryneform bacteria in which the poxB gene is attenuated.
    Type: Application
    Filed: October 1, 2001
    Publication date: October 17, 2002
    Applicant: DEGUSSA AG
    Inventors: Nicole Dusch, Hermann Thomas, Georg Thierbach
  • Publication number: 20020137169
    Abstract: The present invention relates to polynucleotides corresponding to the nadC gene and which encode the nicotinate nucleotide pyrophosphorylase protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having nicotinate nucleotide pyrophosphorylase activity.
    Type: Application
    Filed: February 22, 2001
    Publication date: September 26, 2002
    Applicant: Degussa-Huels Aktiengesellschaft
    Inventors: Christine Bastuck, Brigitte Bathe, Nicole Dusch, Bettina Moeckel, Georg Thierbach
  • Publication number: 20020137163
    Abstract: The present invention relates to polynucleotides corresponding to the nadA gene and which encode the quinolinate synthetase A protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having quinolinate synthetase A activity.
    Type: Application
    Filed: February 22, 2001
    Publication date: September 26, 2002
    Applicant: Degussa-Huels Aktiengesellschaft
    Inventors: Christine Bastuck, Brigitte Bathe, Nicole Dusch, Bettina Moeckel, Georg Thierbach
  • Publication number: 20020106748
    Abstract: The invention provides novel isolated polynucleotides containing a polynucleotide sequence chosen from the group
    Type: Application
    Filed: December 4, 2000
    Publication date: August 8, 2002
    Inventors: Bettina Mockel, Anke Weissenborn, Walter Pfefferle, Achim Marx, Alfred Puhler, Jorn Kalinowski, Brigitte Bathe, Nicole Dusch
  • Publication number: 20020076770
    Abstract: The invention relates to a process for preparing D-pantothenic acid using Coryneform bacteria in which the zwa1 gene is enhanced.
    Type: Application
    Filed: September 17, 2001
    Publication date: June 20, 2002
    Applicant: DEGUSSA AG
    Inventors: Nicole Dusch, Georg Thierbach