Patents by Inventor Nicole K. PAULK

Nicole K. PAULK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted In Vivo Genome Modification
    Publication number: 20220136004
    Abstract: An in vivo method of modifying a genome of a target cell in a mammalian subject is described. The method includes administering an effective amount of a transducer cell to the subject, where the transducer cell includes a regulated viral vector delivery system (RVVDS) for producing and releasing viral transduction particles (VTPs) when the transducer cell is exposed to inducing conditions, and each VTP comprises a nucleic acid encoding a genome modification system (GMS) comprising a genome modification protein and one or more elements that regulate expression or activity of the genome modification protein in a mammalian cell.
    Type: Application
    Filed: January 13, 2020
    Publication date: May 5, 2022
    Inventors: Andrew P May, Eleonore Tham, Lucy Maynard, Marco Mignardi, Nicole K. Paulk, Ryan T. Leenay, Gagandeep Renuka Kumar
  • Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
    Patent number: 10532111
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 14, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. Kay, Nicole K. Paulk
  • NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS WITH ENHANCED HUMAN SKELETAL MUSCLE TROPISM
    Publication number: 20190390176
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human muscle tissue or cells as compared non-variant parent capsid polypeptides.
    Type: Application
    Filed: July 3, 2019
    Publication date: December 26, 2019
    Inventors: Mark A. Kay, Nicole K. Paulk
  • Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
    Patent number: 10385320
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human muscle tissue or cells as compared non-variant parent capsid polypeptides.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 20, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. Kay, Nicole K. Paulk
  • Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
    Patent number: 10179176
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 15, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. Kay, Nicole K. Paulk
  • NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES
    Publication number: 20170360962
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
    Type: Application
    Filed: August 18, 2017
    Publication date: December 21, 2017
    Inventors: Mark A. Kay, Nicole K. Paulk
  • NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES
    Publication number: 20170348433
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
    Type: Application
    Filed: February 16, 2017
    Publication date: December 7, 2017
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark A. KAY, Nicole K. PAULK
  • Novel Recombinant Adeno-Associated Virus Capsids with Enhanced Human Skeletal Muscle Tropism
    Publication number: 20170159026
    Abstract: The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human muscle tissue or cells as compared non-variant parent capsid polypeptides.
    Type: Application
    Filed: December 2, 2016
    Publication date: June 8, 2017
    Inventors: Mark A. KAY, Nicole K. PAULK