Patents by Inventor Nicole TRAINOR

Nicole TRAINOR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES
    Publication number: 20250145608
    Abstract: The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: November 30, 2022
    Publication date: May 8, 2025
    Inventors: Joachim BROEKER, Jason ABBOTT, Alessio CIULLI, Jianwen CUI, Emelyne DIERS, William FARNABY, Stephen W. FESIK, Andreas GOLLNER, Jake GOODWIN-TINDALL, Tim HODGES, Christiane KOFINK, Andrew LITTLE, Andreas MANTOULIDIS, Ross MCLENNAN, Johannes POPOW, Dhruba SARKAR, Martin SCHMIEDEL, Christian Alan Paul SMETHURST, Nicole TRAINOR, Alex WATERSON, Harald WEINSTABL, Siying ZHONG, David ZOLLMAN
  • NOVEL TETRAHYDROQUINOLINES AND PROTEOLYSIS TARGETING CHIMERA (PROTACS) COMPRISING THEM AS DEGRADERS OF SMARCA
    Publication number: 20250049929
    Abstract: The present invention encompasses compounds of formula (I), wherein the groups A, R1, R3 and R4 have the meanings given in the claims and specification, proteolysis targeting chimera (PROTACs) comprising such compounds of formula (I), their use as degraders of SMARCA, pharmaceutical compositions which contain PROTACs of this kind and their medical uses, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: September 27, 2022
    Publication date: February 13, 2025
    Inventors: Alessio CIULLI, Emelyne DIERS, William FARNABY, Peter GREB, Christiane KOFINK, Steffen STEURER, Nicole TRAINOR, Harald WEINSTABL
  • Proteolysis targeting chimera (PROTACS) as degraders of SMARCA2 and /or SMARCA4
    Patent number: 12187719
    Abstract: The present invention encompasses compounds of formula (1) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: January 7, 2025
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Alessio Ciulli, Christian Dank, Emelyne Diers, William Farnaby, Michael Roy, Steffen Steurer, Nicole Trainor
  • PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND /OR SMARCA4
    Publication number: 20210380579
    Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
    Type: Application
    Filed: October 14, 2019
    Publication date: December 9, 2021
    Inventors: Alessio CIULLI, Christian DANK, Emelyne DIERS, William FARNABY, Michael ROY, Steffen STEURER, Nicole TRAINOR