Patents by Inventor Niels Bergenhem

Niels Bergenhem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Modifying Cell Motility Using Factor VIIa Antagonist
    Publication number: 20070232542
    Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 4, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Methods for modifying cell motility using factor VIIa antagonist
    Publication number: 20050245449
    Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
    Type: Application
    Filed: July 6, 2005
    Publication date: November 3, 2005
    Applicant: Novo Nordisk, A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Methods for modifying cell motility using a factor VIIa antagonist
    Publication number: 20030040481
    Abstract: A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
    Type: Application
    Filed: September 6, 2002
    Publication date: February 27, 2003
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Methods for modifying cell motility using factor VIIa or inactivated factor VIIa
    Patent number: 6461610
    Abstract: The present invention provides methods for modifying the motility of tissue factor (TF)-expressing cells, which are carried out by contacting such cells with an effective amount of Factor VIIai Factor VIIa agonist.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: October 8, 2002
    Assignee: Novo Nordisk A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster, Mirella Ezban, Agneta Siegbahn
  • Identification of drug candidates modulating factor VII-mediated intracellular signaling
    Patent number: 6268163
    Abstract: The present invention provides methods for identifying candidate drugs that modulate factor VIIa-mediated intracellular signaling by measuring the effects of such drugs on the activation of the mitogen-activated protein kinase (MAP kinase) signaling pathway.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: July 31, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Lars Kongsbak, Niels Bergenhem, Lars Christian Petersen, Ole Thastrup, Don Foster