Patents by Inventor Niels Lassen

Niels Lassen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4650900
    Abstract: The present invention relates to novel amino alkyl substituted urea derivatives as well as their acid addition salts with pharmaceutically acceptable acids, to methods for the preparation of said derivatives and pharmaceutical compositions containing same, and a method for the treatment of tumors therewith.The novel urea derivatives have shown pronounced anti-neoplastic activity when tested against various tumor models in animals.The novel compounds of the present invention may be represented by the following formula: ##STR1## wherein X and Y are the same or different and are selected from the group consisting of a phenyl group, each of said phenyl groups being optionally substituted with one or two groups selected from halogen, CF.sub.3, OH, or alkoxy (1-4 C-atoms); and R.sup.1 and R.sup.
    Type: Grant
    Filed: December 30, 1985
    Date of Patent: March 17, 1987
    Assignee: H. Lundbeck A/S
    Inventors: Niels Lassen, Klaus P. Bogeso, Klaus G. Jensen
  • Patent number: 4309429
    Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.
    Type: Grant
    Filed: December 21, 1979
    Date of Patent: January 5, 1982
    Assignee: Kefalas A/S
    Inventors: Niels Lassen, Klaus P. Bogeso, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
  • Patent number: 4285956
    Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: August 25, 1981
    Assignee: Kefalas A/S
    Inventors: Niels Lassen, Klaus P. Boges, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
  • Patent number: 4275209
    Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.
    Type: Grant
    Filed: December 21, 1979
    Date of Patent: June 23, 1981
    Assignee: Kefalas A/S
    Inventors: Niels Lassen, Klaus P. Bogeso, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
  • Patent number: 4153694
    Abstract: The present invention relates to novel behenic acid esters of the following general formula: ##STR1## wherein X is "N" or "CH," the non-toxic acid addition salts thereof, a method for the preparation of said esters and therapeutic compositions thereof having prolonged effect.It is an object of the present invention to provide behenic acid esters of Formula I, a method of making the same, a method for the alleviation, palliation, mitigation or inhibition of the manifestations of certain physiological-psychological abnormalities of animals therewith, and pharmaceutical compositions comprising such compounds as active ingredient.Other objects will be apparent to one skilled in the art and still other objects will become apparent hereinafter.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: May 8, 1979
    Assignee: Kefalas A/S
    Inventors: Jorn L. M. Buus, Niels Lassen
  • Patent number: 4044024
    Abstract: Fluoro-substituted thiaxanthene derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, methods of preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.
    Type: Grant
    Filed: July 7, 1975
    Date of Patent: August 23, 1977
    Assignee: Kefalas A/S
    Inventors: Jorn Lasse Martin Buus, Niels Lassen, Allan Johan Bigler
  • Patent number: 4042695
    Abstract: Fluoro-substituted thiaxanthene derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, methods of preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: August 16, 1977
    Assignee: Kefalas A/S
    Inventors: Jorn Lasse Martin Buus, Niels Lassen, Allan Johan Bigler
  • Patent number: 4038395
    Abstract: The present invention relates to the novel alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof, the non-toxic acid addition salts of these compounds, methods of preparing and purifying the said compounds, therapeutic compositions thereof and a method of treating psychotic patients therewith.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: July 26, 1977
    Assignee: Kefalas A/S
    Inventor: Niels Lassen
  • Patent number: 3996211
    Abstract: The present invention relates to the novel alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof, the non-toxic acid addition salts of these compounds, methods of preparing and purifying the said compounds, therapeutic compositions thereof and a method of treating psychotic patients therewith.
    Type: Grant
    Filed: June 17, 1974
    Date of Patent: December 7, 1976
    Assignee: Kefalas A/S
    Inventor: Niels Lassen
  • Patent number: 3966930
    Abstract: Fluoro-substituted phenothiazine derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, a method for the preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.
    Type: Grant
    Filed: May 30, 1974
    Date of Patent: June 29, 1976
    Assignee: Kefalas A/S
    Inventors: Jorn Lasse Martin Buus, Niels Lassen