Patents by Inventor Nikolai Nikolaevich Romanov

Nikolai Nikolaevich Romanov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11884825
    Abstract: The present application relates to exocyclic amine-substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: January 30, 2024
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Carole Anastasi, Patrick McCauley
  • Patent number: 11858923
    Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: January 2, 2024
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Patrick McCauley, Carole Anastasi, Xiaolin Wu, Niall Hynes
  • Publication number: 20230313292
    Abstract: The present application relates to chromenoquinoline dyes and their uses as fluorescent labels. For example, these dyes may be used to label nucleotides for nucleic acid sequencing.
    Type: Application
    Filed: March 27, 2023
    Publication date: October 5, 2023
    Inventors: Michael Callingham, Niall Hynes, Nikolai Nikolaevich Romanov
  • Publication number: 20230265503
    Abstract: Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.
    Type: Application
    Filed: May 2, 2023
    Publication date: August 24, 2023
    Inventors: Xiaolin WU, Xiaohai LIU, Nikolai Nikolaevich ROMANOV, Antoine FRANCAIS, Patrick MCCAULEY, Michael CALLINGHAM, Carole ANASTASI
  • Publication number: 20230265502
    Abstract: Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.
    Type: Application
    Filed: February 14, 2023
    Publication date: August 24, 2023
    Inventors: Xiaolin WU, Xiaohai LIU, Nikolai Nikolaevich ROMANOV, Antoine FRANCAIS, Patrick MCCAULEY, Michael CALLINGHAM, Carole ANASTASI
  • Patent number: 11597969
    Abstract: Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: March 7, 2023
    Assignee: Illumina Cambridge Limited
    Inventors: Xiaolin Wu, Xiaohai Liu, Nikolai Nikolaevich Romanov, Antoine Francais, Patrick McCauley, Michael Callingham, Carole Anastasi
  • Publication number: 20230022437
    Abstract: The present application relates to exocyclic amine-substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: July 1, 2022
    Publication date: January 26, 2023
    Inventors: Nikolai Nikolaevich Romanov, Carole Anastasi, Patrick McCauley
  • Publication number: 20230025669
    Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: July 1, 2022
    Publication date: January 26, 2023
    Inventors: Nikolai Nikolaevich ROMANOV, Patrick MCCAULEY, Carole ANASTASI, Xiaolin WU, Niall HYNES
  • Publication number: 20220380389
    Abstract: The present application relates to substituted dyes containing bis-boron fused heterocycles and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: May 4, 2022
    Publication date: December 1, 2022
    Inventors: Michael Callingham, Nikolai Nikolaevich Romanov, Xiaohai Liu, Justyna Piekos
  • Patent number: 11390619
    Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: July 19, 2022
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Patrick McCauley, Carole Anastasi, Xiaolin Wu, Niall Hynes
  • Patent number: 11390753
    Abstract: The present application relates to exocyclic amine-substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 19, 2022
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Carole Anastasi, Patrick McCauley
  • Patent number: 11371078
    Abstract: The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: June 28, 2022
    Assignee: Illumina Cambridge Limited
    Inventor: Nikolai Nikolaevich Romanov
  • Publication number: 20220195516
    Abstract: The present disclosure relates to methods, systems, kits and compositions for nucleic acid sequencing applications. In particular, the method utilizes two imaging events with different excitation wavelengths and a single emission channel to collect the fluorescent signal patterns of different types of nucleotide conjugates to determine the identity of the incorporated nucleotide conjugates. The method described herein does not require a chemical treatment of the nucleotide conjugates in the incorporation mixture between the two imaging events.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 23, 2022
    Inventors: Xiaohai LIU, Xiaolin WU, Patrick MCCAULEY, Nikolai Nikolaevich ROMANOV, Elena CRESSINA, Antoine FRANCAIS
  • Publication number: 20220033900
    Abstract: The present application relates to substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: July 26, 2021
    Publication date: February 3, 2022
    Inventors: Nikolai Nikolaevich ROMANOV, Michael CALLINGHAM, Carole ANASTASI, Patrick MCCAULEY, Niall HYNES, Natasha CRAKE, Xiaolin WU, Xiaohai LIU
  • Publication number: 20210188832
    Abstract: The present application relates to secondary amine-substituted coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: October 16, 2018
    Publication date: June 24, 2021
    Inventors: Nikolai Nikolaevich ROMANOV, Patrick MCCAULEY, Carole ANASTASI, Xiaolin WU, Niall HYNES
  • Publication number: 20210155977
    Abstract: The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: January 29, 2021
    Publication date: May 27, 2021
    Inventor: Nikolai Nikolaevich Romanov
  • Publication number: 20210155983
    Abstract: Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.
    Type: Application
    Filed: November 24, 2020
    Publication date: May 27, 2021
    Inventors: Xiaolin WU, Xiaohai LIU, Nikolai Nikolaevich ROMANOV, Antoine FRANCAIS, Patrick MCCAULEY, Michael CALLINGHAM, Carole ANASTASI
  • Patent number: 10907196
    Abstract: The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: February 2, 2021
    Assignee: Illumina Cambridge Limited
    Inventor: Nikolai Nikolaevich Romanov
  • Publication number: 20200277529
    Abstract: The present application relates to exocyclic amine-substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 3, 2020
    Inventors: Nikolai Nikolaevich Romanov, Carole Anastasi, Patrick McCauley
  • Patent number: RE49362
    Abstract: Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a variety of applications, such as in assays involving staining of cells, protein binding, and analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 10, 2023
    Assignee: Illumina Cambridge Limited
    Inventors: Colin Barnes, Nikolai Nikolaevich Romanov