Patents by Inventor Nikolaos Deliolanis
Nikolaos Deliolanis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10684224Abstract: Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence images and reflection images of an object including alternatingly illuminating the object with at least a first light and a second light, wherein the first light and the second light are spectrally shaped such that at least one light has several spectral regions of high light intensity separated by spectral region(s) of low light intensity, wherein the spectral regions of the first light and the second light with high intensity at least partially do not overlap and wherein at least one of the two lights has at least one region of low light intensity that is of longer wavelength to the neighboring region of high light intensity, and recording at least a first image of the object and a second image of the object while illuminating the object with at least one of the lights.Type: GrantFiled: June 3, 2015Date of Patent: June 16, 2020Assignee: Universität HeidelbergInventors: Nikolas Dimitriadis, Nikolaos Deliolanis
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Patent number: 10481095Abstract: Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence and reflectance images of an object including alternatingly illuminating the object with at least a first light having several spectral regions of high intensity, wherein the first light has at least one region of low intensity that is of longer wavelength to a region of high intensity, and at least a second light having at least one spectral region of high intensity, recording a first image of the object during illumination of the object with the first light and a second image of the object during illumination of the object with the second light using a common sensor array, wherein the light recorded by the sensor array is attenuated in at least one of the spectral regions in which the first light has high intensities.Type: GrantFiled: June 3, 2015Date of Patent: November 19, 2019Assignee: Universität HeidelbergInventors: Nikolas Dimitriadis, Nikolaos Deliolanis
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Publication number: 20170176336Abstract: Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence images and reflection images of an object including alternatingly illuminating the object with at least a first light and a second light, wherein the first light and the second light are spectrally shaped such that at least one light has several spectral regions of high light intensity separated by spectral region(s) of low light intensity, wherein the spectral regions of the first light and the second light with high intensity at least partially do not overlap and wherein at least one of the two lights has at least one region of low light intensity that is of longer wavelength to the neighboring region of high light intensity, and recording at least a first image of the object and a second image of the object while illuminating the object with at least one of the lights.Type: ApplicationFiled: June 3, 2015Publication date: June 22, 2017Applicant: Universität HeidelbergInventors: Nikolas DIMITRIADIS, Nikolaos DELIOLANIS
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Publication number: 20170167980Abstract: Multispectral imaging of samples, in particular of biological tissues. A method for acquisition of fluorescence and reflectance images of an object including alternatingly illuminating the object with at least a first light having several spectral regions of high intensity, wherein the first light has at least one region of low intensity that is of longer wavelength to a region of high intensity, and at least a second light having at least one spectral region of high intensity, recording a first image of the object during illumination of the object with the first light and a second image of the object during illumination of the object with the second light using a common sensor array, wherein the light recorded by the sensor array is attenuated in at least one of the spectral regions in which the first light has high intensities.Type: ApplicationFiled: June 3, 2015Publication date: June 15, 2017Applicant: Universität HeidelbergInventors: Nikolas DIMITRIADIS, Nikolaos DELIOLANIS
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Patent number: 9551789Abstract: The disclosure relates to systems and methods for optoacoustic imaging of an object comprising, in some embodiments, an image acquisition unit for acquiring a first sequence of tomographic optoacoustic images, the image acquisition unit comprising an illumination device and a detection device configured for repeatedly collecting acoustic waves emerging from the object and for generating the first sequence of tomographic optoacoustic images. In some embodiments, a processing unit is provided for generating a second sequence of one or more tomographic optoacoustic images from the first sequence of tomographic optoacoustic images based on an analysis of one or more tomographic optoacoustic images of the first sequence of tomographic optoacoustic images and/or at least one property of the object while acquiring the first sequence of tomographic optoacoustic images and/or at least one property of the acquisition unit while acquiring the first sequence of tomographic optoacoustic images.Type: GrantFiled: December 27, 2013Date of Patent: January 24, 2017Assignee: Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (GMBH)Inventors: Stefan Morscher, Vasilis Ntziachristos, Nikolaos Deliolanis
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Publication number: 20150366458Abstract: An imaging apparatus (100), configured for thermoacoustic tomographic imaging a region of interest (2) in an object (1), comprises a source device (10) being arranged for emitting an electromagnetic energy input into the region of interest (2), a detector device (20) being arranged for detecting mechanical wave response signals generated in the region of interest (2) along multiple angular projection directions in response to the electromagnetic energy input, and an image data acquisition and processing device (30) being arranged for providing tomographic image data representing the image of the region of interest (2) on the basis of the mechanical wave response signals, wherein the source device (10) is adapted for continuously emitting the electromagnetic energy input with a predetermined input modulation, and the image data acquisition and processing device (30) is adapted for converting the mechanical wave response signals into the frequency domain and for performing data processing and image reconstructiType: ApplicationFiled: May 7, 2012Publication date: December 24, 2015Applicant: Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (GmbH)Inventors: Stephan Kellnberger, Vasilis Ntziachristos, George Sergiadis, Nikolaos Deliolanis, Murad Omar
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Publication number: 20150225467Abstract: The present invention relates to a nucleic acid molecule encoding a polypeptide having a fluorescence emission activity at a wavelength of at least 630 nm, wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO: 1, with the exception that in the polypeptide of SEQ ID NO: 1 (b-i) glutamic acid at the position corresponding to position 16 is replaced by glycine; (b-ii) asparagine at the position corresponding to position 125 is replaced by aspartic acid; and/or (b-iii) lysine at the position corresponding to position 185 is replaced by asparagine; (c) a nucleic acid molecule encoding a polypeptide having at least 94% sequence identity to the polypeptide encoded by the nucleic acid molecule of (a) or (b); (d) a nucleic acid molecule having the nucleotide sequence of SEQ ID NO: 2; (e) a nucleic acid moType: ApplicationFiled: August 9, 2013Publication date: August 13, 2015Inventors: Randolph B. Caldwell, Ulrike Schötz, Steffen Heuer, Wolfgang Beisker, Nikolaos Deliolanis
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Publication number: 20140198606Abstract: The disclosure relates to systems and methods for optoacoustic imaging of an object comprising, in some embodiments, an image acquisition unit for acquiring a first sequence of tomographic optoacoustic images, the image acquisition unit comprising an illumination device and a detection device configured for repeatedly collecting acoustic waves emerging from the object and for generating the first sequence of tomographic optoacoustic images. In some embodiments, a processing unit is provided for generating a second sequence of one or more tomographic optoacoustic images from the first sequence of tomographic optoacoustic images based on an analysis of one or more tomographic optoacoustic images of the first sequence of tomographic optoacoustic images and/or at least one property of the object while acquiring the first sequence of tomographic optoacoustic images and/or at least one property of the acquisition unit while acquiring the first sequence of tomographic optoacoustic images.Type: ApplicationFiled: December 27, 2013Publication date: July 17, 2014Applicant: Helmsholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)Inventors: Stefan Morscher, Vasilis Ntziachristos, Nikolaos Deliolanis