Patents by Inventor Nila Patil
Nila Patil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11031098Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: GrantFiled: May 31, 2016Date of Patent: June 8, 2021Assignee: Genetic Technologies LimitedInventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Publication number: 20160371429Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: ApplicationFiled: May 31, 2016Publication date: December 22, 2016Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Publication number: 20110020815Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: ApplicationFiled: June 7, 2010Publication date: January 27, 2011Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Publication number: 20080026367Abstract: The present invention relates to business methods for discovery of therapeutic and diagnostic products by identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response.Type: ApplicationFiled: May 30, 2003Publication date: January 31, 2008Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Nila Patil, Anthony Berno, David Hinds
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Publication number: 20060188875Abstract: The invention provides nucleic acid segments of the human genome including polymorphic sites, SNP haplotype blocks, SNP haplotype patterns for each block and informative SNPs for each pattern. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as association studies and other genetic analyses.Type: ApplicationFiled: October 31, 2002Publication date: August 24, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Nila Patil, Anthony Berno, David Hinds
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Publication number: 20050272086Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: ApplicationFiled: June 29, 2005Publication date: December 8, 2005Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David Cox, Anthony Berno, David Hinds
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Patent number: 6969589Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: GrantFiled: March 26, 2002Date of Patent: November 29, 2005Assignee: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Patent number: 6963805Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.Type: GrantFiled: October 5, 2001Date of Patent: November 8, 2005Assignee: Perlegen Sciences, Inc.Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
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Patent number: 6897025Abstract: Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.Type: GrantFiled: January 7, 2002Date of Patent: May 24, 2005Assignee: Perlegen Sciences, Inc.Inventors: David R. Cox, Bradley A. Margus, Nila Patil
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Publication number: 20050100911Abstract: The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired properly. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high decree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.Type: ApplicationFiled: August 6, 2003Publication date: May 12, 2005Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David Cox, Charit Pethiyagoda, Andrew Sparks, Huang-Tsu Chen
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Publication number: 20050019787Abstract: Computer-implemented methods, data processing apparatus and computer program codes for characterizing an interrogation position, such as a SNP position, in a nucleic acid sequence are provided herein. Computer-implemented methods involving various statistical analyses are provided for characterizing an interrogation position as being associated with a phenotypic trait of interest.Type: ApplicationFiled: January 30, 2004Publication date: January 27, 2005Applicant: Perlegen Sciences, Inc., a Delaware CorporationInventors: Anthony Berno, Karel Konvicka, David Hinds, Nila Patil, Naiping Shen, David Stern, John Sheehan
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Publication number: 20040241657Abstract: Composition and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of liver related disease, inflammatory disease and related conditions are disclosed. Also provided are kits and reagents for prognosis and diagnosis of liver related disease, inflammatory disease and related conditions.Type: ApplicationFiled: May 28, 2003Publication date: December 2, 2004Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Coleen R. Hacker, David Hinds, David Kershenobich, Naiping Shen
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Patent number: 6740510Abstract: The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for designing primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.Type: GrantFiled: January 9, 2002Date of Patent: May 25, 2004Assignee: Perlegen Sciences, Inc.Inventors: Curtis R. Kautzer, Nila Patil, Coleen R. Hacker, David P. McDonough
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Publication number: 20040029161Abstract: The present invention relates to business methods for discovery of therapeutic and diagnostic products by identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response.Type: ApplicationFiled: May 30, 2003Publication date: February 12, 2004Applicant: Perlegen Sciences, Inc.Inventors: David R. Cox, Nila Patil, Anthony J. Berno, David A. Hinds
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Publication number: 20040023237Abstract: The present invention relates to methods for identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response. The methods allow for, once variants have been identified, analysis of SNPs in coding regions of control and experimental populations.Type: ApplicationFiled: October 31, 2002Publication date: February 5, 2004Applicant: Perelegen Sciences Inc.Inventors: Nila Patil, David R. Cox
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Publication number: 20040023275Abstract: The present invention relates to methods for identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response. The methods allow for, once variants have been identified, determining variant haplotype blocks and patterns, and further, resolving ambiguities in the haplotype block and pattern data sets.Type: ApplicationFiled: April 29, 2003Publication date: February 5, 2004Applicant: Perlegen Sciences, Inc.Inventors: Anthony J. Berno, Nila Patil, David R. Cox, David A. Hinds
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Publication number: 20030119015Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.Type: ApplicationFiled: May 8, 2002Publication date: June 26, 2003Applicant: Perlegen Sciences, Inc.Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
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Publication number: 20030108919Abstract: The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for selecting primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.Type: ApplicationFiled: September 5, 2002Publication date: June 12, 2003Applicant: Perlegen Sciences, Inc.Inventors: Curtis Kautzer, Nila Patil, Coleen Hacker, David P. McDonough, Daryl J. Thomas, Wade A. Barrett, John B. Sheehan
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Publication number: 20030099964Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: ApplicationFiled: March 26, 2002Publication date: May 29, 2003Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Publication number: 20030073093Abstract: The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for designing primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.Type: ApplicationFiled: January 9, 2002Publication date: April 17, 2003Applicant: Perlegen Sciences, Inc.Inventors: Curtis Kautzer, Nila Patil, Coleen Hacker, David P. McDonough