Patents by Inventor Nilesh Dagdu Patil

Nilesh Dagdu Patil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesis of cyclic octapeptide
    Patent number: 8377891
    Abstract: This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Cys(Trt)-2-Chlorotrityl resin is coupled with various amino acids to obtain a protected heptapeptide of formula (2): Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-2-Chlorotrityl resin. The linear protected peptide of formula (2) is cleaved from the support using TFA5TIS and water to yield linear protected peptide of formula (3) Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-OH Linear protected heptapeptide of formula (3) is deprotected to yield heptapeptide of formula (6): D-Phe-Cys-Phe-D-Tip-Lys-Thr-Cys-OH; which is cyclized using hydrogen peroxide and to the cyclic peptide of formula (7) D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-OH; threoninol is coupled at C terminal to yield octreotide.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 19, 2013
    Assignee: USV, Ltd.
    Inventors: Divya Lal Saksena, Digamber Shripati Pawar, Nikhil Umesh Mohe, Nilesh Dagdu Patil, Chandrakesan Muralidharan, Lester Lobo, Radhakrishnan Venkatasubramanian Tarur
  • Process for Synthesis of Cyclic Octapeptide
    Publication number: 20120035117
    Abstract: This invention relates a process for preparing octreotide and derivatives thereof. The starting material, Cys(Trt)-2-Chlorotrityl resin is coupled with various amino acids to obtain a protected heptapeptide of formula (2): Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-2-Chlorotrityl resin. The linear protected peptide of formula (2) is cleaved from the support using TFA5TIS and water to yield linear protected peptide of formula (3) Boc-D-Phe-Cys(Trt)-Phe-D-Trp-Lys(Boc)-Thr(OBut)-Cys(Trt)-OH Linear protected heptapeptide of formula (3) is deprotected to yield heptapeptide of formula (6): D-Phe-Cys-Phe-D-Tip-Lys-Thr-Cys-OH; which is cyclized using hydrogen peroxide and to the cyclic peptide of formula (7) D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-OH; threoninol is coupled at C terminal to yield octreotide.
    Type: Application
    Filed: May 4, 2009
    Publication date: February 9, 2012
    Inventors: Divya Lal Saksena, Digamber Shripati Pawar, Nikhil Umesh Mohe, Nilesh Dagdu Patil, Chandrakesan Muralidharan, Lester Lobo, Radhakrishnan Venkatasubramanian Tarur
  • Process for PEGylation of Proteins
    Publication number: 20110196134
    Abstract: The present invention relates to a process for improving pegylation reaction yield of r-metHuG-CSF comprising conjugating r-metHuG-CSF to a PEG aldehyde at a free amine moiety at the N terminal end on the G-CSF in presence of a reducing agent in a pegylation buffer solution comprising a polyol having the formula CnH2n+2On where n is from 3 to 6, or a carbohydrate, or a derivative thereof wherein the concentration of said polyol or carbohydrate or derivative thereof is in the range of 0.1% to 10% w/w.
    Type: Application
    Filed: May 4, 2009
    Publication date: August 11, 2011
    Applicant: USV LIMITED
    Inventors: Nikhil Umesh Mohe, Radhakrishnan Venkatsubramanian Tarur, Dinesh Kumar Paliwal, Divya Lal Saksena, Nilesh Dagdu Patil, Muralidharan Chandrakesan, Digamber Shripati Pawar, Rakesh Shekhawat, Aruna Khare, Sagar Satyanarayan Zawar, Pankaj Prabhakar Malpure, Dilip Kumar Rana