Patents by Inventor Nino Mchedlishvili

Nino Mchedlishvili has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkylene-dicarboxylate-containing biodegradable poly(ester-amides) and methods of use
    Patent number: 8445627
    Abstract: The invention provides new aliphatic diester-di-acid-containing PEA polymer compositions with significant improvement in hydrolytic degradation rates as compared to aliphatic di-acid-containing PEA polymers. The di-acids used in the invention PEA compositions include non-toxic fatty aliphatic homologs. These molecules inherently contain two-ester groups, which easily can be cleaved by biotic (enzymatic) and abiotic hydrolysis. Additional di-acid-type compounds useful for active polycondensation are ?,?-alkylene dicarboxylates composed of short aliphatic non toxic diols and di-acids. In addition, the invention PEA polymer compositions optionally can include a second monomer, such as a C-protected L-lysine-based monomer, to introduce additional chain flexibility into the polymer. The invention PEA polymer compositions are useful for delivery of bioactive agents when administered internally.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: May 21, 2013
    Assignee: Medivas, LLC
    Inventors: Ramaz Katsarava, Natia Mazanashvili, Zaza D. Gomurashvili, Turner Daniel Jenkins, Nino Mchedlishvili
  • Alkylene-dicarboxylate-containing biodegradable poly(ester-amides) and methods of use
    Publication number: 20070287987
    Abstract: The invention provides new aliphatic diester-di-acid-containing PEA polymer compositions with significant improvement in hydrolytic degradation rates as compared to aliphatic di-acid-containing PEA polymers. The di-acids used in the invention PEA compositions include non-toxic fatty aliphatic homologs. These molecules inherently contain two-ester groups, which easily can be cleaved by biotic (enzymatic) and abiotic hydrolysis. Additional di-acid-type compounds useful for active polycondensation are ?,?-alkylene dicarboxylates composed of short aliphatic non toxic diols and di-acids. In addition, the invention PEA polymer compositions optionally can include a second monomer, such as a C-protected L-lysine-based monomer, to introduce additional chain flexibility into the polymer. The invention PEA polymer compositions are useful for delivery of bioactive agents when administered internally.
    Type: Application
    Filed: March 22, 2007
    Publication date: December 13, 2007
    Applicant: MediVas, LLC
    Inventors: Ramaz Katsarava, Natia Mazanashvili, Zaza Gomurashvili, Turner Jenkins, Nino Mchedlishvili