Patents by Inventor Nobuhiko Ozaki
Nobuhiko Ozaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100133122Abstract: An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode.Type: ApplicationFiled: January 22, 2010Publication date: June 3, 2010Inventors: Nobuhiko OZAKI, Hiroaki Oka
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Publication number: 20100120166Abstract: A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrate. The substrate can be rotated about a rotation axis as the center, and has the channel portion including the chambers formed therein. The inner wall of each chamber has a first area including an area intersecting with a centrifugal direction from the center; and also has a second area placed at a position farther from the center than the first area, and including a surface intersecting with the centrifugal direction from the center. Further, the first area has a region for holding a droplet of a liquid provided; and also has a region where a contact with the droplet expands when the substrate is rotated, and that communicate with the second area.Type: ApplicationFiled: April 4, 2008Publication date: May 13, 2010Applicant: PANASONIC CORPORATIONInventors: Nobuhiko Ozaki, Tomohiro Yamamoto
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Patent number: 7678249Abstract: An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode.Type: GrantFiled: August 30, 2005Date of Patent: March 16, 2010Assignee: Panasonic CorporationInventors: Nobuhiko Ozaki, Hiroaki Oka
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Publication number: 20100062414Abstract: A sample liquid analytical chip that whilst being of simple structure, has a reaction region and a detection region isolated from each other and further has liquid feed control means for a sample liquid, thereby realizing speedy reliable analysis. The sample liquid analytical chip comprises a tubular sample liquid transfer channel with its both ends open, a reaction reagent layer disposed on the internal wall surface of the sample liquid transfer channel and a detection region for detecting any physical or chemical change of the sample liquid. In the sample liquid analytical chip, the sample liquid transfer channel at an area of its wall surface is provided an opening and a lid fitted to the opening. Portion of the lid forms a hinge in cooperation with the wall surface.Type: ApplicationFiled: April 4, 2008Publication date: March 11, 2010Applicant: PANASONIC CORPORATIONInventors: Tomohiro Yamamoto, Tetsuo Yukimasa, Ryou Hamada, Fumihisa Kitawaki, Nobuhiko Ozaki
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Patent number: 7604776Abstract: A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing unit is provided with: a liquid sample reserve unit; a reagent chamber capable of disposing a plurality of the solid reagents; and a measurement chamber to which a sample mixture liquid containing a liquid sample and a solid reagent mixed in the reagent chamber is supplied. The reagent chamber has a form which allows a plurality of the solid reagents to be disposed in the direction substantially parallel to the radial direction of the disc in which centrifugal force is generated, or in the direction substantially perpendicular to the radial direction of the disc.Type: GrantFiled: May 1, 2008Date of Patent: October 20, 2009Assignee: Panasonic CorporationInventors: Tomohiro Yamamoto, Toshihiko Yoshioka, Nobuhiko Ozaki
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Patent number: 7594984Abstract: The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.Type: GrantFiled: January 12, 2007Date of Patent: September 29, 2009Assignee: Panasonic CorporationInventors: Hiroaki Oka, Nobuhiko Ozaki, Hirokazu Sugihara
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Publication number: 20090238724Abstract: It is an object of the present invention to provide a disc for analyzing a fluid sample, which can analyze the fluid sample with accuracy by having the fluid sample react quickly and uniformly with the solid reagent held in the chamber. The disc has a chamber is defined by a gap formed with at least two opening, and defined by a spacer intervening between an upper substrate and a lower substrate, the upper substrate having a convex section, the lower substrate having a concave section, the reagent being attached to the concave section of the lower substrate.Type: ApplicationFiled: October 31, 2006Publication date: September 24, 2009Applicant: MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.Inventors: Tomohiro Yamamoto, Nobuhiko Ozaki
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Publication number: 20090118112Abstract: A chamber chip 17 is provided with a pre-branching chamber 21, branching chamber 22, and a guiding fluid passage 24 for these chambers 21. The branching chamber 22 has a separation wall 23 which defines two branching compartments 29A and 29B. A wall surface of the branching chamber positioned at a side of the rotary shaft 13 has a spread angle ?e from an outlet end section 24b of the guiding fluid passage 24 which is an obtuse angle. The rotation of the chamber chip 17 about the rotary shaft 13 causes a liquid 23 to flow from the pre-branching chamber 21 through the guiding fluid passage 24 into the branching chamber 22. By a Coriolis force acting in an opposite direction to a rotation direction R1, R2 about the rotary shaft 13, the liquid 23 is selectively supplied to any one of the branching compartments 29A and 29B.Type: ApplicationFiled: December 31, 2008Publication date: May 7, 2009Applicant: PANASONIC CORPORATIONInventor: Nobuhiko OZAKI
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Patent number: 7497996Abstract: A liquid delivery apparatus 1 has a rotary substrate 2. The substrate 2 formed with a fluid passage 8A for communicating a supply chamber 6A and target chamber 7A. An inlet end portion 13 at which the fluid passage 8A is connected to the chamber 6A extends in a clockwise direction R1 of rotational directions of the substrate 2. The inlet end portion 13 holds a liquid 9 in the chamber 6A by a capillary force. The rotation drive unit 4 rotates the substrate 2 so that an inertial force exceeding the capillary force and directed to the clockwise direction R1 acts on the liquid 9 in the inlet end portion 13. Delivery behavior control of microfluid with a high degree of flexibility can be achieved.Type: GrantFiled: September 6, 2006Date of Patent: March 3, 2009Assignee: Panasonic CorporationInventors: Nobuhiko Ozaki, Hiroaki Oka, Tetsuo Yukimasa, Hidenobu Yaku, Maki Yotsuhashi, Yukari Hataoka
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Patent number: 7462324Abstract: A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.Type: GrantFiled: November 19, 2002Date of Patent: December 9, 2008Assignee: Panasonic CorporationInventors: Nobuhiko Ozaki, Hiroaki Oka, Hirokazu Sugihara
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Publication number: 20080257726Abstract: A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.Type: ApplicationFiled: June 5, 2008Publication date: October 23, 2008Applicant: Matsushita Electric Industrial Co., Ltd.Inventors: Masaya NAKATANI, Nobuhiko Ozaki, Hiroaki Oka
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Publication number: 20080257727Abstract: A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.Type: ApplicationFiled: June 5, 2008Publication date: October 23, 2008Applicant: Matsushita Electric Industrial Co., Ltd.Inventors: Masaya NAKATANI, Nobuhiko Ozaki, Hiroaki Oka
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Publication number: 20080237039Abstract: A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.Type: ApplicationFiled: June 5, 2008Publication date: October 2, 2008Applicant: Matsushita Electric Industrial Co., Ltd.Inventors: Masaya NAKATANI, Nobuhiko OZAKI, Hiroaki OKA
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Publication number: 20080227217Abstract: A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing unit is provided with: a liquid sample reserve unit; a reagent chamber capable of disposing a plurality of the solid reagents; and a measurement chamber to which a sample mixture liquid containing a liquid sample and a solid reagent mixed in the reagent chamber is supplied. The reagent chamber has a form which allows a plurality of the solid reagents to be disposed in the direction substantially parallel to the radial direction of the disc in which centrifugal force is generated, or in the direction substantially perpendicular to the radial direction of the disc.Type: ApplicationFiled: May 1, 2008Publication date: September 18, 2008Applicant: MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.Inventors: Tomohiro YAMAMOTO, Toshihiko YOSHIOKA, Nobuhiko OZAKI
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Patent number: 7396673Abstract: A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell.Type: GrantFiled: November 17, 2004Date of Patent: July 8, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Masaya Nakatani, Nobuhiko Ozaki, Hiroaki Oka
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Patent number: 7368083Abstract: The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.Type: GrantFiled: July 28, 2006Date of Patent: May 6, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Nobuhiko Ozaki, Hiroaki Oka, Tetsuo Yukimasa, Hidenobu Yaku, Maki Yotsuhashi, Yukari Hataoka
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Patent number: 7326384Abstract: A device for detecting a physicochemical change in a biological sample comprising at least one measuring electrode provided by causing a conductive material to enter into a porous film, and a conductor connected to the measuring electrode.Type: GrantFiled: July 29, 2002Date of Patent: February 5, 2008Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroaki Oka, Nobuhiko Ozaki, Hirokazu Sugihara
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Publication number: 20070134651Abstract: The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.Type: ApplicationFiled: January 12, 2007Publication date: June 14, 2007Applicant: MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.Inventors: Hiroaki Oka, Nobuhiko Ozaki, Hirokazu Sugihara
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Publication number: 20070105183Abstract: A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.Type: ApplicationFiled: July 14, 2005Publication date: May 10, 2007Inventors: Masaya Nakatani, Nobuhiko Ozaki, Hiroaki Oka
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Patent number: 7172860Abstract: The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.Type: GrantFiled: October 6, 2003Date of Patent: February 6, 2007Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroaki Oka, Nobuhiko Ozaki, Hirokazu Sugihara