Patents by Inventor Nobuhiro Hanafusa

Nobuhiro Hanafusa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190368977
    Abstract: An extraction portion which is a piece of a micro sampling chip is safely cut, and the cut extraction portion can be accommodated in a predetermined container without impairing quantitativeness of a sample. A sample extraction tool comprises a through hole for cutting the extraction portion from the micro sampling chip by bending the micro sampling chip while inserting the extraction portion to the through hole, the sample extraction tool is configured to be attached to an upper portion of a container for accommodating the extraction portion in such a state that the through hole is disposed on an open upper surface of the container.
    Type: Application
    Filed: May 9, 2019
    Publication date: December 5, 2019
    Applicant: SHIMADZU CORPORATION
    Inventor: Nobuhiro HANAFUSA
  • Patent number: 10488374
    Abstract: The present invention provides a preprocessing device of a more compact structure, and an analysis system provided with the same. A preprocessing device (1) includes a container holding section (12), a filtration port (30), and a transport arm (24). The container holding section (12) holds a separation container (50) and a collection container (54). The filtration port (30) separates a sample by applying pressure to a sample in the separation container (50). The transport arm (24) transports the separation container (50) and the collection container (54) held by the container holding section (12) from a predetermined transport position.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: November 26, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Nobuhiro Hanafusa, Shin Nakamura, Hiroshi Tanihata
  • Patent number: 10473630
    Abstract: A preprocessing kit includes a separation device, a collecting container, and a skirt part. The skirt part is integrated with the separation device, and is provided to surround an outer circumferential surface of the separation device with a clearance being left from the outer circumferential surface so that a space having a closed upper side and an open lower side is formed between the outer circumferential surface of the separation device and the skirt part. The skirt part is provided in such a way that a lower end of the skirt part comes into intimate contact with a peripheral surface of an opening of the recess part when the collecting container containing the lower end of the separation device is fitted into the recess part.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: November 12, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Nobuhiro Hanafusa, Kenichi Kitamura
  • Patent number: 10391483
    Abstract: A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: August 27, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Masaki Kanai, Takahiro Nishimoto, Masakazu Akechi, Nobuhiro Hanafusa
  • Publication number: 20190234983
    Abstract: A pretreatment apparatus includes a pretreatment container placement section where a pretreatment container which is housing a specimen holding member including a microchannel for holding a specimen is placed; a carrying mechanism for carrying the pretreatment container that is placed at the pretreatment container placement section; and a pretreatment section including a port where the pretreatment container that is carried by the carrying mechanism is placed, the pretreatment section being configured to perform pretreatment including a shaking process of shaking the pretreatment container to extract the specimen from the specimen holding member in the pretreatment container that is placed in the port.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Applicant: SHIMADZU CORPORATION
    Inventor: Nobuhiro HANAFUSA
  • Publication number: 20190154553
    Abstract: A pretreating apparatus includes a transferring mechanism configured to transfer a storing container storing an unpretreated sample or a pretreated sample, a pretreating portion having a port in which the storing container storing the sample is installed by the transferring mechanism, configured to pretreat the sample in the storing container installed in the port, and a diluting portion configured to suck a predetermined amount of the pretreated sample from the storing container and supply the sample and a diluent to an empty storing container to dilute the sample.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 23, 2019
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Daisuke KAWAKAMI, Hikaru SHIBATA, Takafumi TANIGAKI
  • Publication number: 20180252682
    Abstract: Disclosed herein is a preprocessing apparatus that makes it possible to highly efficiently analyze specimens held by solid media, such as dried blood spots to be used for newborn mass screening or the like. The preprocessing apparatus includes: a preprocessing container setting part in which a preprocessing container containing a solid sample including a specimen to be analyzed and a solid medium holding the specimen is to be set; a carrying mechanism that carries the preprocessing container set in the preprocessing container setting part; and a preprocessing part that has a port for setting the preprocessing container carried by the carrying mechanism and that is configured to perform preprocessing including extraction processing for extracting the specimen from the solid sample contained in the preprocessing container set in the port.
    Type: Application
    Filed: February 27, 2018
    Publication date: September 6, 2018
    Applicant: SHIMADZU CORPORATION
    Inventor: Nobuhiro HANAFUSA
  • Patent number: 10029253
    Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: July 24, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Masakazu Akechi, Masaki Kanai, Takahiro Nishimoto, Nobuhiro Hanafusa
  • Publication number: 20180196016
    Abstract: Provided are a pretreatment device capable of starting pretreatment in a simple operation, and an analysis system provided with the pretreatment device. A container holding unit 12 holds pretreatment containers into each of which a sample is injected, at a plurality of holding positions. A pretreatment unit sequentially performs pretreatment by using the pretreatment containers held at the holding positions of the container holding unit 12 in a specific order. A position setting receiving means 84d receives a setting of the holding position of a pretreatment container to be used first among the plurality of holding positions in the case where a series of pretreatments using the plurality of pretreatment containers is started by the pretreatment unit.
    Type: Application
    Filed: July 9, 2015
    Publication date: July 12, 2018
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Kazuhiro SUZUKI
  • Publication number: 20170284982
    Abstract: The present invention provides a preprocessing device of a more compact structure, and an analysis system provided with the same. A preprocessing device (1) includes a container holding section (12), a filtration port (30), and a transport arm (24). The container holding section (12) holds a separation container (50) and a collection container (54). The filtration port (30) separates a sample by applying pressure to a sample in the separation container (50). The transport arm (24) transports the separation container (50) and the collection container (54) held by the container holding section (12) from a predetermined transport position.
    Type: Application
    Filed: September 2, 2014
    Publication date: October 5, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Shin NAKAMURA, Hiroshi TANIHATA
  • Publication number: 20170284981
    Abstract: The present invention provides a processing device with a high degree of flexibility in setting of preprocessing and which is capable of increasing the preprocessing efficiency, and an analysis system provided with the same. Setting receiving means (84d) receives, for each sample, setting of a plurality of types of preprocessing and a parameter for each preprocessing. A preprocessing execution section (84e) controls a plurality of preprocessing sections and a transport arm (24) so that a plurality of types of preprocessing set for each of different samples is performed simultaneously in parallel. The preprocessing execution section (84e) performs control in such a way that preprocessing is not to be performed on different samples at the same preprocessing section at the same.
    Type: Application
    Filed: September 2, 2014
    Publication date: October 5, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Kazuhiro SUZUKI
  • Publication number: 20170168027
    Abstract: A preprocessing kit includes a separation device, a collecting container, and a skirt part. The skirt part is integrated with the separation device, and is provided to surround an outer circumferential surface of the separation device with a clearance being left from the outer circumferential surface so that a space having a closed upper side and an open lower side is formed between the outer circumferential surface of the separation device and the skirt part. The skirt part is provided in such a way that a lower end of the skirt part comes into intimate contact with a peripheral surface of an opening of the recess part when the collecting container containing the lower end of the separation device is fitted into the recess part.
    Type: Application
    Filed: September 2, 2014
    Publication date: June 15, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Kenichi KITAMURA
  • Publication number: 20170138824
    Abstract: A preprocessing apparatus uses preprocessing kits prepared for samples, respectively, sets the preprocessing kits in plural processing ports provided so as to correspond to preprocessing items, and executes a predetermined preprocessing item. A controller which controls operations of a carrying mechanism holding and carrying the preprocessing kits, and processing parts executing the preprocessing items in the respective processing ports, includes a processing-state control part, a random access part, and a preprocessing part. The random access part is configured to check availability of a preprocessing port corresponding to a preprocessing item to be executed on a sample contained in a preprocessing kit, and set the preprocessing kit in a processing port if the processing port is available as a processing port corresponding to the preprocessing item. The preprocessing part executes a corresponding preprocessing item on a sample in a preprocessing kit when the preprocessing kit is set in the processing port.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 18, 2017
    Applicant: SHIMADZU CORPORATION
    Inventors: Nobuhiro HANAFUSA, Masamitsu SHIKATA
  • Patent number: 9550184
    Abstract: Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and (21) connected to the reaction well (5). The reaction well channel has a main channel (13), a metering channel (15) branched off the main channel (13), and an injection channel (17) of which one end is connected to the metering channel (15) and the other end is connected to the reaction well (5). The main channel (13) and the reaction well air vent channel (21) can be hermetically sealed.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: January 24, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Nobuhiro Hanafusa, Koretsugu Ogata, Takahiro Nishimoto, Masaki Kanai
  • Publication number: 20160214109
    Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
    Type: Application
    Filed: April 6, 2016
    Publication date: July 28, 2016
    Inventors: Masakazu Akechi, Masaki Kanai, Takahiro Nishimoto, Nobuhiro Hanafusa
  • Patent number: 9308530
    Abstract: Disclosed herein is a reaction container plate which prevents the entry of foreign matter from the outside and the pollution of an outside environment. A reaction container plate (1) includes a sealed reaction container (5), a reaction container channel (15) connected to the reaction container (5), a sealed container (17) provided separately from the reaction container (5), a sealed container channel (17a) connected to the sealed container (17), a syringe (33) for sending a liquid, a switching valve (47) for connecting the syringe (33) to the introduction channel (15) or the sealed container channel (17a), and a sealed container air vent channel (17b) of which one end is connected to the sealed container (17).
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: April 12, 2016
    Assignee: SHIMADZU CORPORATION
    Inventor: Nobuhiro Hanafusa
  • Patent number: 8697010
    Abstract: A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: April 15, 2014
    Assignee: Shimadzu Corporation
    Inventors: Masaki Kanai, Takahiro Nishimoto, Masakazu Akechi, Nobuhiro Hanafusa
  • Publication number: 20140079603
    Abstract: A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: Shimadzu Corporation
    Inventors: Masaki Kanai, Takahiro Nishimoto, Masakazu Akechi, Nobuhiro Hanafusa
  • Publication number: 20140051160
    Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
    Type: Application
    Filed: October 11, 2013
    Publication date: February 20, 2014
    Applicant: SHIMADZU CORPORATION
    Inventors: Masakazu Akechi, Masaki Kanai, Takahiro Nishimoto, Nobuhiro Hanafusa
  • Patent number: D738525
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: September 8, 2015
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroshi Muraoka, Shin Nakamura, Nobuhiro Hanafusa