Abstract: An object to be achieved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including at least one kind selected from the group consisting of mebendazole and itraconazole or a salt thereof.

Abstract: Provided is an optical modulator having an optical modulation high frequency line through which a high frequency electrical signal can be efficiently input to an optical modulation region and which is in a broadband. High frequency lines of an optical modulator, that is, an input high frequency line, an optical modulation high frequency line, and an output high frequency line have a line configuration in which each of the input high frequency line and the output high frequency line is divided into a plurality of segments, and adjacent segments of the plurality of the segments have different characteristic impedances and propagation constants. The input high frequency line and the output high frequency line may be implemented by changing a width or a thickness of a signal electrode formed on a dielectric forming a micro-strip line between adjacent segments.

Abstract: A primary object of the present invention is to provide a method for conveniently and accurately testing for pulmonary hypertension. To achieve this object, the present invention provides a method for testing for pulmonary hypertension using as an indicator the concentration of selenoprotein P protein in a sample derived from a subject.

Abstract: In a terminator, a midpoint electrode is provided between a first signal electrode and a second signal electrode, a first resistor is connected between the first signal electrode and the midpoint electrode, a second resistor is connected between the second signal electrode and the midpoint electrode, a first GND electrode is provided on a side opposite to the side where the first resistor is provided with the first signal electrode interposed therebetween, a second GND electrode is provided on the side opposite to the side where the second resistor is provided with the second signal electrode interposed therebetween, and capacitances in the terminator are formed between the first signal electrode and the midpoint electrode, between the second signal electrode and the midpoint electrode, between the first signal electrode and the first GND electrode, and between the second signal electrode and the second GND electrode.

Abstract: The present invention provides a highly reliable, high-speed, and low-loss semiconductor optical modulation element that protects a pin junction structure in a modulation region against reverse voltage ESD by configuring an additional capacity having a thyristor structure between a plurality of feeding pad electrodes. An n-type contact layer, an n-type cladding layer, a non-doped core/cladding layer, a p-type cladding layer, and a p-type contact layer are sequentially laminated on the substrate surface. A Mach-Zehnder interferometric waveguide and a plurality of feeding pad installation sections are formed by dry etching. The n-type contact layer and the n-type cladding layer are removed except for a modulation region of the Mach-Zehnder interferometric waveguide and a feeding region in which the feeding pad installation sections are formed so that the modulation region and the semiconductor of the lower part of the feeding region are electrically isolated from each other.

Abstract: The present invention provides a highly reliable, high-speed, and low-loss semiconductor optical modulation element that protects a pin junction structure in a modulation region against reverse voltage ESD by configuring an additional capacity having a thyristor structure between a plurality of feeding pad electrodes. An n-type contact layer, an n-type cladding layer, a non-doped core/cladding layer, a p-type cladding layer, and a p-type contact layer are sequentially laminated on the substrate surface. A Mach-Zehnder interferometric waveguide and a plurality of feeding pad installation sections are formed by dry etching. The n-type contact layer and the n-type cladding layer are removed except for a modulation region of the Mach-Zehnder interferometric waveguide and a feeding region in which the feeding pad installation sections are formed so that the modulation region and the semiconductor of the lower part of the feeding region are electrically isolated from each other.

Abstract: An object to be achieved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including at least one kind selected from the group consisting of mebendazole and itraconazole or a salt thereof.

Abstract: Provided is an optical modulator having an optical modulation high frequency line through which a high frequency electrical signal can be efficiently input to an optical modulation region and which is in a broadband. High frequency lines of an optical modulator, that is, an input high frequency line, an optical modulation high frequency line, and an output high frequency line have a line configuration in which each of the input high frequency line and the output high frequency line is divided into a plurality of segments, and adjacent segments of the plurality of the segments have different characteristic impedances and propagation constants. The input high frequency line and the output high frequency line may be implemented by changing a width or a thickness of a signal electrode formed on a dielectric forming a micro-strip line between adjacent segments.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing an ingredient having a selenoprotein P activity-inhibiting action.

Abstract: This invention provides a high-frequency line adopting a structure to suppress an impedance variation and occurrence of an excessive power loss in high-frequency wiring having intersection with an optical waveguide. A high-frequency line is a microstrip line which has a basic configuration of stacking a ground electrode, a dielectric layer, and a signal electrode in this order on a SI-InP substrate. In addition, as shown in a transverse sectional view, an optical waveguide core made of InP-based semiconductor intersects with the high-frequency line in a crossing manner. A width of the signal electrode is partially increased in a certain region covering the intersection with the optical waveguide along a propagating direction of the high-frequency line. In the microstrip line, the width of the signal electrode is partially increased from w1 to w2, and characteristic impedance is thus reduced as compared to one with the uniform width w1.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing an ingredient having a selenoprotein P activity-inhibiting action.

Abstract: To provide a Mach-Zehnder (MZ) type semiconductor optical modulation element that can be used as a modulator, which is ultrafast and excellent in electrical stability. A semiconductor optical modulation element of a Mach-Zehnder type that performs modulation of light using a refractive index modulation region where a refractive index of the light guided to an optical waveguide is modulated and an input and output region where multiplexing/demultiplexing of the light split in the refractive index modulation region is performed, characterized in that in the refractive index modulation region of the optical waveguide, an n-type clad layer, an i core layer, and a p-type clad layer are stacked in the order from a top layer on a substrate surface equivalent to a (100) plane of a sphalerite-type seminsulating semiconductor crystal substrate, the n-type clad layer is formed in a ridge shape in an inverted mesa direction, and a capacitancl-oaded electrode is provided on the n-type clad layer.

Abstract: An optical modulator driver circuit (1) includes an amplifier (50, Q10, Q11, R10-R13), and a current amount adjustment circuit (51) capable of adjusting a current amount of the amplifier (50) in accordance with a desired operation mode. The current amount adjustment circuit (51) includes at least two current sources (IS10) that are individually ON/OFF-controllable in accordance with a binary control signal representing the desired operation mode.

Abstract: A primary object of the present invention is to provide a method for conveniently and accurately testing for pulmonary hypertension. To achieve this object, the present invention provides a method for testing for pulmonary hypertension using as an indicator the concentration of selenoprotein P protein in a sample derived from a subject.

Abstract: An image forming apparatus includes an image forming station, a mounting portion for mounting one of fixing devices, each including a first roller and a second roller which cooperate to form a nip for fixing a toner image on a sheet fed from the image forming station, a rubbing roller configured to rub a surface of the first roller, a storing portion capable of storing information, a counter for counting sheets fed to the fixing device mounted on the mounting portion and to store a number indicative of the number counted by the counter in the storing portion of the fixing device, and an executing portion for effecting a rubbing treatment to the first roller of the fixing device, when the number counted by the counter on the basis of the number in the storing portion of the fixing device mounted on the mounting portion exceeds a predetermined number.

Abstract: An image forming apparatus includes an input portion into which a job is to be input, an image forming portion configured to form a toner image on a recording material to execute the job input into the input portion, a fixing portion configured to fix, on the recording material, the toner image formed by the image forming portion, the fixing portion being capable of being replaced with another fixing portion depending on a content of the job, a selecting portion configured to prompt an operator to select one of a plurality of modes before a plurality of jobs are successively reserved, and a controller configured to control the execution order of reserved jobs. The controller can change the execution order of the plurality of jobs so as to decrease the number of times of replacement of the fixing portion, or the controller can maintain the execution order of the plurality of jobs in a reserved order.

Abstract: An image heating apparatus includes a first heater for heating a first roller, a second heater for heating a second roller, a first sensor for detecting a temperature of a region of an endless belt supported by the first roller, a second sensor for detecting a temperature of a region of the endless belt supported by the second roller, and a controller for controlling energization to the first heater and to the second heater. The controller executes a first mode in which the energization to the first heater is controlled using an output of the first sensor and the energization to the second heater is controlled using an output of the second sensor, and a second mode in which the energization to the first heater and the second heater is controlled using the output of the first sensor without using the output of the second sensor.

Abstract: An image forming apparatus has an image forming station, a mounting portion, and a fixing portion that includes a first rotatable member, a second rotatable member, a rubbing rotatable member configured to rub a surface of the first rotatable member during a rubbing treatment, and a storing portion capable of storing number information. A number of recording materials fed to the fixing portion is counted, written into the storing portion, and used to determine whether to execute the rubbing treatment. In a case in which, in sequence, the recording material is fed to the mounted fixing portion, the mounted fixing portion is removed and replaced with another fixing portion, and the removed fixing portion is remounted, both number information acquired from the storing portion and the number of recording materials fed to the remounted fixing portion are used to determine whether to execute the rubbing treatment.

Abstract: An image forming apparatus includes an input portion into which a job is to be input, an image forming portion configured to form a toner image on a recording material to execute the job input into the input portion, a fixing portion configured to fix, on the recording material, the toner image formed by the image forming portion, the fixing portion being capable of being replaced with another fixing portion depending on a content of the job, a selecting portion configured to prompt an operator to select one of a plurality of modes before a plurality of jobs are successively reserved, and a controller configured to control the execution order of reserved jobs. The controller can change the execution order of the plurality of jobs so as to decrease the number of times of replacement of the fixing portion, or the controller can maintain the execution order of the plurality of jobs in a reserved order.

Abstract: This invention provides a high-frequency line adopting a structure to suppress an impedance variation and occurrence of an excessive power loss in high-frequency wiring having intersection with an optical waveguide. A high-frequency line is a microstrip line which has a basic configuration of stacking a ground electrode, a dielectric layer, and a signal electrode in this order on a SI-InP substrate. In addition, as shown in a transverse sectional view, an optical waveguide core made of InP-based semiconductor intersects with the high-frequency line in a crossing manner. A width of the signal electrode is partially increased in a certain region covering the intersection with the optical waveguide along a propagating direction of the high-frequency line. In the microstrip line, the width of the signal electrode is partially increased from w1 to w2, and characteristic impedance is thus reduced as compared to one with the uniform width w1.