Patents by Inventor Nobuyoshi Minami

Nobuyoshi Minami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7385029
    Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: June 10, 2008
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
  • Patent number: 7087624
    Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group.
    Type: Grant
    Filed: October 27, 2003
    Date of Patent: August 8, 2006
    Assignee: Teikoju Hormone Mfg. Co., Ltd.
    Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
  • Patent number: 7008928
    Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: March 7, 2006
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
  • Publication number: 20050267041
    Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S, 2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
    Type: Application
    Filed: July 14, 2005
    Publication date: December 1, 2005
    Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
  • Publication number: 20040254343
    Abstract: The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.
    Type: Application
    Filed: March 22, 2004
    Publication date: December 16, 2004
    Inventors: Koichi Miyazaki, Katsuyuki Keino, Arihiro Kanada, Nobuyoshi Minami
  • Publication number: 20040087628
    Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n —Y, —CH2 —CH(R4)-(A)n—Y, —CO—B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 6, 2004
    Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
  • Patent number: 6667325
    Abstract: Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: December 23, 2003
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
  • Patent number: 6511997
    Abstract: Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: January 28, 2003
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Nobuyoshi Minami, Michitaka Sato, Koichi Hasumi, Norio Yamamoto, Katsuyuki Keino, Teruaki Matsui, Arihiro Kanada, Shuji Ohta, Takahisa Saito, Shuichiro Sato, Akira Asagarasu, Satoshi Doi, Motohiro Kobayashi, Jun Sato, Hajime Asano
  • Patent number: 5464147
    Abstract: To connect cylindrical members, e.g., pipes to each other by welding, a tandem type internal clamp composed of two or more clamps is used as an essential component. Prior to each welding operation, the tandem type internal clamp is located in position in a pipe to be newly connected to a pipe already connected to a preceding pipe. At this time, one of the clamps corresponding to a circular welding seam is slightly projected outside of one end of the new pipe. As expansion ring segments are radially displaced in the outward direction, seal ring segments are brought in close contact with the inner peripheral surface of the new pipe. Subsequently, the new pipe is displaced toward the already connected pipe until the tapered welding edges of both the pipes abut against each other, causing the projected part of the clamp to be inserted into the already connected pipe.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: November 7, 1995
    Assignee: Chiyoda Corporation
    Inventor: Nobuyoshi Minami
  • Patent number: 5221674
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: June 22, 1993
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
  • Patent number: 5130314
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: July 14, 1992
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
  • Patent number: 5082844
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: January 21, 1992
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
  • Patent number: 4337256
    Abstract: Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2##in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.
    Type: Grant
    Filed: December 27, 1979
    Date of Patent: June 29, 1982
    Assignee: Teikoku Hormone Manufacturing Co., Ltd.
    Inventors: Yasushi Suzuki, Kunio Tsukamoto, Nobuyoshi Minami, Yukio Hasegawa, Michitaka Satoh, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Satoshi Funakoshi
  • Patent number: 4230703
    Abstract: Compounds of the general formula ##STR1## or their salts, esters or amide derivatives; and processes for their preparation. In the formula, R.sub.O represents hydrogen or lower alkyl, R.sub.2 represents hydrogen, halogen or nitro, R.sub.3 represents hydrogen or halogen, and R.sub.4 represents hydrogen or lower alkyl; and when R.sub.O is hydrogen, R.sub.2, R.sub.3 and R.sub.4 are all hydrogens and the group ##STR2## is present at the 2-position. These compounds exhibit superior analgesic and/or anti-inflammatory actions with little gastrointestinal troubles.
    Type: Grant
    Filed: March 28, 1978
    Date of Patent: October 28, 1980
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Yasushi Suzuki, Kunio Tsukamoto, Nobuyoshi Minami, Yukio Hasegawa, Tadaharu Watanabe, Katsuhiko Miyasaka, Takashi Mikami, Satoshi Funakoshi