Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.

Abstract: Disclosed is a method for producing an alkaline phosphatase fusion antibody, comprising: culturing a cell comprising an expression vector comprising a gene encoding alkaline phosphatase derived from bovine small intestine or Shewanella bacterium and a gene encoding an antibody in a medium comprising a zinc ion, and acquiring an alkaline phosphatase fusion antibody expressed by the cell.

Abstract: Disclosed is a method for acquiring information on exacerbation risk of COVID-19, comprising measuring IgM antibody against S antigen of SARS-CoV-2 contained in a specimen collected from a subject infected with SARS-CoV-2 or a subject suspected of suffering from COVID-19, wherein a value obtained by the measurement of IgM antibody serves as an index of exacerbation risk of COVID-19 of the subject.

Abstract: Disclosed is a method for measuring a viral antigen using a capture antibody and a detection antibody, the method comprising forming a sandwich immune complex that contains the capture antibody, the viral antigen and the detection antibody, the capture antibody comprising a heavy chain variable region that comprises CDR1 comprising amino acid sequence of SEQ ID NO: 1, CDR2 comprising amino acid sequence of SEQ ID NO: 2 and CDR3 comprising amino acid sequence of SEQ ID NO: 3, and a light chain variable region that comprises CDR1 comprising amino acid sequence of SEQ ID NO: 4, CDR2 comprising amino acid sequence of SEQ ID NO: 5 and CDR3 comprising amino acid sequence of SEQ ID NO: 6, and the detection antibody comprising a heavy chain variable region that comprises CDR1 comprising amino acid sequence of SEQ ID NO: 7, CDR2 comprising amino acid sequence of SEQ ID NO: 8 and CDR3 comprising amino acid sequence of SEQ ID NO: 9, and a light chain variable region that comprises CDR1 comprising amino acid sequence of

Abstract: Disclosed is a method for producing an alkaline phosphatase fusion antibody, comprising: culturing a cell comprising an expression vector comprising a gene encoding alkaline phosphatase derived from bovine small intestine or Shewanella bacterium and a gene encoding an antibody in a medium comprising a zinc ion, and acquiring an alkaline phosphatase fusion antibody expressed by the cell.

Abstract: Disclosed is a method for producing a modified antibody, comprising: in a heavy chain of the antibody, changing at least one amino acid residue selected from the group consisting of 8th to 11th amino acid residues based on Kabat method to a cysteine residue, and changing at least one amino acid residue selected from the group consisting of 109th and 110th amino acid residues based on IMGT method to a cysteine residue; and recovering the modified antibody.

Abstract: Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant region based on the Kabat method are substituted with cysteine in an antibody in which the 80th amino acid residue in the variable region and the 171th amino acid residue in the constant region are not cysteine.

Abstract: The present invention provides an oil-based cosmetic that can easily be washed out with warm water and is excellent in water resistance. The oil-based cosmetic of the present invention is characterized by comprising (a) to (c): (a) 1 to 25 mass % of a block-type alkylene oxide derivative represented by the below-described formula (I) (b) 1 to 15 mass % of a siliconized pullulan and/or trimethylsiloxysilicic acid (c) 10 mass % or less of water R1O—[(EO)p(PO)q(EO)r]—R2??(I) (In the above formula, EO is an oxyethylene group and PO is an oxypropylene group. The symbols p, q, and r are the average addition mole numbers, and they are p?1, r?1, 10?p+r?70, and 10?q?60. R1 and R2 are either identical or different and they are either a hydrogen atom or a hydrocarbon group having 1 to 3 carbon atoms.

Abstract: Disclosed is an antibody in which the 80th amino acid residue in a variable region based on the Kabat method and the 171th amino acid residue in a constant region based on the Kabat method are substituted with cysteine in an antibody in which the 80th amino acid residue in the variable region and the 171th amino acid residue in the constant region are not cysteine.

Abstract: The present invention provides an oil-based cosmetic that can easily be washed out with warm water and is excellent in water resistance. The oil-based cosmetic of the present invention is characterized by comprising (a) to (c): (a) 1 to 25 mass % of a block-type alkylene oxide derivative represented by the below-described formula (I) (b) 1 to 15 mass % of a siliconized pullulan and/or trimethylsiloxysilicic acid (c) 10 mass % or less of water R1O—[(EO)p(PO)q(EO)r]—R2??(I) (In the above formula, EO is an oxyethylene group and PO is an oxypropylene group. The symbols p, q, and r are the average addition mole numbers, and they are p?1, r?1, 10?p+r?70, and 10?q?60. R1 and R2 are either identical or different and they are either a hydrogen atom or a hydrocarbon group having 1 to 3 carbon atoms.

Abstract: To provide a cosmetic for eyelashes, which is excellent in the effect of imparting a feeling of voluminousness to eyelashes and exerts high base transparency without damage to the color inherent in the cosmetic base. Means of attaining the object A cosmetic for eyelashes which comprises (a) a silicone resin powder of particles having such a spiky-surface-sugar-candy-ball-like shape that small protrusions are present over the whole surface of each particle, (b) a volatile oil (e.g., low-boiling-point isoparaffinic hydrocarbon oil, low-boiling-point silicone oil, etc.), and (c) an oily gelling agent. Preferably, the cosmetic contains 1-20% by weight of component (a), 10-80% by mass of component (b) and 1-25% by mass of component (c). The cosmetic may optionally contain (d) a film-forming agent.

Abstract: An oil-based cosmetic composition having high temperature stability, giving a coating film after evaporation of a solvent having a high gloss, and excellent in forming of a coloring material when the coloring matter, particularly a hair cosmetic composition such as mascara, etc., containing (a) a dextrin fatty acid ester, (b) a sucrose fatty acid ester having an average substitution degree of the ester of 3 to 8, and (c) an optional oil component which is solid at 30° C. in an amount of 5 mass % or less and, if desired, (d) a fluid oil which is liquid at 30° C. (i.e., not evaporating at an ordinary temperature) in an amount of 1 to 50 mass %, (e) a coloring material in an amount of 0.01 to 30 mass %, (f) a coating agent in an amount of 1 to 40 mass %, and (g) a volatile oil in an amount of 30 to 80 mass %.

Abstract: There is provided a cosmetic material removing agent including an expansive clay mineral and a dextrin fatty acid ester. There is provided a cosmetic material removing device including the cosmetic material removing agent as described above and a container for containing and feeding the cosmetic material removing agent.

Abstract: An oil-based cosmetic composition having high temperature stability, giving a coating film after evaporation of a solvent having a high gloss, and excellent in forming of a coloring material when the coloring matter, particularly a hair cosmetic composition such as mascara, etc., containing (a) a dextrin fatty acid ester, (b) a sucrose fatty acid ester having an average substitution degree of the ester of 3 to 8, and (c) an optional oil component which is solid at 30° C. in an amount of 5 mass % or less and, if desired, (d) a fluid oil which is liquid at 30° C. (i.e., not evaporating at an ordinary temperature) in an amount of 1 to 50 mass %, (e) a coloring material in an amount of 0.01 to 30 mass %, (f) a coating agent in an amount of 1 to 40 mass %, and (g) a volatile oil in an amount of 30 to 80 mass %.

Abstract: The present invention is an oil-in-polyhydric-alcohol type warming base agent containing the following ingredients: 1. Polyhydric alcohol; 20.0-99.0 wt % of the total amount 2. Sucrose fatty acid ester; 0.5-10.0 wt % of the total amount 3. Oil: 30.0-80.0 wt % of the total amount The object of the present invention is to provide an oil-in-polyhydric-alcohol type warming base agent which is superior in terms of its make-up removal effect, safety (low irritation), stability, and warming sensation.

Abstract: The present invention is an oil-in-polyhydric-alcohol type warming base agent containing the following ingredients: