Patents by Inventor Nobuyuki Yasuda

Nobuyuki Yasuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11465254
    Abstract: One object is to provide a polishing machine and a polishing method capable of improving a processing accuracy on the surface of an object. A method of polishing an object is provided. Such a method comprises: a first step of polishing an object by moving the object and a first polishing pad having a smaller dimension than that of the object relative to each other while the first polishing pad is made to contact the object, a second step of polishing the object, after the first step of polishing, by moving the object and a second polishing pad having a larger dimension than that of the object relative to each other while the second polishing pad is made to contact the object, and a step of detecting the state of the surface of the object before the first step of polishing.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: October 11, 2022
    Assignee: Ebara Corporation
    Inventors: Itsuki Kobata, Katsuhide Watanabe, Hozumi Yasuda, Yuji Yagi, Nobuyuki Takahashi, Koichi Takeda
  • Publication number: 20220263839
    Abstract: A computer system comprises an analysis module configured to execute dynamic analysis for a sample of a malicious program, and to output an analysis result including a coupling destination to and from which the malicious program communicates; a variation detection module configured to detect variation of the coupling destination based on results of cyclic observation of the coupling destination, and to output a result of the detection; and an information sharing module configured to store information output from the analysis module and information output from the variation detection module in a form that allows sharing among a plurality of external computers.
    Type: Application
    Filed: March 5, 2020
    Publication date: August 18, 2022
    Inventors: Shota FUJII, Masato TERADA, Takayuki SATOU, Sho AOKI, Tomohiro SHIGEMOTO, Nobutaka KAWAGUCHI, Yu TSUDA, Nobuyuki KANAYA, Shingo YASUDA, Daisuke INOUE
  • Publication number: 20220205980
    Abstract: An object of the present invention is to provide a method for predicting a therapeutic effect of a drug that inhibits FKN-CX3CR1 interaction on rheumatoid arthritis in a rheumatoid arthritis subject, and novel and more effective therapeutic agent for rheumatoid arthritis exploiting the method. In order to predict a therapeutic effect of a drug that inhibits fractalkine (FKN)-CX3CR1 interaction in a rheumatoid arthritis subject, provided is a method comprising predicting the therapeutic effect of the drug in the subject on the basis of a measurement value of CD16+ monocytes in a biological sample obtained from the subject before the start of administration of the drug.
    Type: Application
    Filed: April 20, 2020
    Publication date: June 30, 2022
    Inventors: Nobuyuki Yasuda, Tomohiro Yamada, Fumitoshi Tago, Seiichiro Hojo, Toshio Imai
  • Patent number: 11052150
    Abstract: It is an object of the present invention to provide a pharmaceutical composition comprising an anti-fractalkine antibody that provides therapeutically effective improvement to Crohn's disease, after the administration thereof to a human subject, and a method for treating Crohn's disease. Provided is a pharmaceutical composition for treating Crohn's disease. The present pharmaceutical composition comprises an anti-fractalkine antibody and a pharmaceutically acceptable excipient, and is used, such that the anti-fractalkine antibody is intravenously administered to a human at a dose of at least 10 mg/kg of human body weight in a method for treating Crohn's disease.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: July 6, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Nobuyuki Yasuda, Kiyoshi Oketani, Hiroko Baba, Tomohisa Nakano, Masahiko Mori
  • Publication number: 20180303933
    Abstract: It is an object of the present invention to provide a pharmaceutical composition comprising an anti-fractalkine antibody that provides therapeutically effective improvement to Crohn's disease, after the administration thereof to a human subject, and a method for treating Crohn's disease. Provided is a pharmaceutical composition for treating Crohn's disease. The present pharmaceutical composition comprises an anti-fractalkine antibody and a pharmaceutically acceptable excipient, and is used, such that the anti-fractalkine antibody is intravenously administered to a human at a dose of at least 10 mg/kg of human body weight in a method for treating Crohn's disease.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 25, 2018
    Inventors: Nobuyuki Yasuda, Kiyoshi Oketani, Hiroko Baba, Tomohisa Nakano, Masahiko Mori
  • Patent number: 9965839
    Abstract: An apparatus for quality inspection of shafts includes a rotary table having cutout grooves at the outer periphery thereof. The rotary table includes an upper disk and a lower disk stacked in the vertical direction so as to be rotatable relative to each other; and plate members provided on the upper surface of the lower disk and inserted in respective first cutouts formed at the outer periphery of the upper disk. One of groove edges of each cutout groove is constituted by one side edge of each first cutout, and the other groove edge is constituted by one side edge of each plate member. Second cutout, corresponding to the first cutout and provided in the lower disk, are grooves including side edges, and an end edge perpendicular to the side edges. The distance between these side edges is larger than the maximum groove width of the cutout grooves.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: May 8, 2018
    Assignee: Yutaka Co., Ltd.
    Inventor: Nobuyuki Yasuda
  • Publication number: 20180111988
    Abstract: An object of the present invention is to provide a pharmaceutical composition comprising an anti-fractalkine antibody, and a method for treating rheumatoid arthritis using the pharmaceutical composition, wherein the pharmaceutical composition and the method bring about therapeutically effective amelioration in rheumatoid arthritis after administration to a human subject. The present invention provides a pharmaceutical composition for the treatment of rheumatoid arthritis. The pharmaceutical composition in a method for treating rheumatoid arthritis comprises an anti-fractalkine antibody and a pharmaceutically acceptable excipient and is used such that at least 100 mg per dose of the anti-fractalkine antibody is subcutaneously administered to a human in need thereof.
    Type: Application
    Filed: October 24, 2017
    Publication date: April 26, 2018
    Inventors: Nobuyuki Yasuda, Fumitoshi Tago, Hiroko Baba, Tomohisa Nakano, Masahiko Mori
  • Publication number: 20160063693
    Abstract: An apparatus for quality inspection of shafts includes a rotary table having cutout grooves at the outer periphery thereof. The rotary table includes an upper disk and a lower disk stacked in the vertical direction so as to be rotatable relative to each other; and plate members provided on the upper surface of the lower disk and inserted in respective first cutouts formed at the outer periphery of the upper disk. One of groove edges of each cutout groove is constituted by one side edge of each first cutout, and the other groove edge is constituted by one side edge of each plate member. Second cutout, corresponding to the first cutout and provided in the lower disk, are grooves including side edges, and an end edge perpendicular to the side edges. The distance between these side edges is larger than the maximum groove width of the cutout grooves.
    Type: Application
    Filed: March 27, 2014
    Publication date: March 3, 2016
    Inventor: Nobuyuki YASUDA
  • Patent number: 7772226
    Abstract: The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: August 10, 2010
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Seiji Yoshikawa, Eita Emori, Fumiyoshi Matsuura, Richard Clark, Hironori Ikuta, Kazunobu Kira, Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki
  • Patent number: 7544841
    Abstract: A novel production method for a phenylethanolamine compound of the following general formula (III): (wherein R1 represents a hydrogen atom or a halogen atom; R2 represents an alkyl group optionally substituted with an alkoxycarbonyl group); and a novel production intermediate for it.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: June 9, 2009
    Assignee: Mitsubishi Tanabe Pharma Corporation
    Inventors: Nobuyuki Yasuda, Tsuyoshi Kajita
  • Publication number: 20090018331
    Abstract: The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
    Type: Application
    Filed: August 28, 2008
    Publication date: January 15, 2009
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Seiji Yoshikawa, Eita Emori, Fumiyoshi Matsuura, Richard Clark, Hironori Ikuta, Kazunobu Kira, Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki
  • Publication number: 20070287864
    Abstract: A novel production method for a phenylethanolamine compound of the following general formula (III): (wherein R1 represents a hydrogen atom or a halogen atom; R2 represents an alkyl group optionally substituted with an alkoxycarbonyl group); and a novel production intermediate for it.
    Type: Application
    Filed: October 19, 2005
    Publication date: December 13, 2007
    Applicant: Mitsubishi Pharma Corporation
    Inventors: Nobuyuki Yasuda, Tsuyoshi Kajita
  • Patent number: 7238720
    Abstract: The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: July 3, 2007
    Assignee: Eisai R & D Management Co. Ltd.
    Inventors: Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki, Seiji Yoshikawa, Toshimi Okada, Hironori Ikuta, Mika Koyanagi
  • Patent number: 7189717
    Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: March 13, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: Masahiro Yasuda, Hitoshi Harada, Shuhei Miyazawa, Seiichi Kobayashi, Kokichi Harada, Takayuki Hida, Hisashi Shibata, Nobuyuki Yasuda, Osamu Asano, Yoshihiko Kotake
  • Publication number: 20070054876
    Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
    Type: Application
    Filed: November 8, 2006
    Publication date: March 8, 2007
    Inventors: Masahiro Yasuda, Hitoshi Harada, Shuhei Miyazawa, Seiichi Kobayashi, Kokichi Harada, Takayuki Hida, Hisashi Shibata, Nobuyuki Yasuda, Osamu Asano, Yoshihiko Kotake
  • Patent number: 7173692
    Abstract: Image inspection is used to inspect defective or non-defective screw heads. An inspection device includes an inspecting portion for positioning and holding a screw, with a head, with the head up, a CCD camera provided right over the inspecting portion, an annular light source arranged between the inspecting portion and the CCD camera, and a determining device for processing an image of the CCD camera and determining whether the screw is defective or non-defective based on this processed image. An operating hole of the screw is illuminated by the annular light source so that no shadow forms to vividly photograph a hole bottom of the operating hole with the CCD camera. It is also possible to inspect a top surface of a head of a screw.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: February 6, 2007
    Assignee: Yutaka Co., Ltd.
    Inventors: Nobuyuki Yasuda, Masahiro Togawa
  • Patent number: 7160892
    Abstract: The invention provides novel pyrimidone compounds exhibiting excellent antagonism against adenosine receptors (A1, A2A, and A2B receptors), particularly, compounds represented by the general formula (1), salts thereof, or solvates of both: (1) wherein R1 and R2 are each independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, a 5- to 14-membered nonaromatic heterocyclic group, a C6-14 aromatic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, C1-6 acyl, or C1-6 alkylsulfonyl; R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl; R4 is a C6-14 aromatic hydrocarbon group; a 5- to 14-membered aromatic heterocyclic group, or a 5- to 14-membered nonaromatic heterocyclic group having at least one unsaturated bond; and R5 is a C6-14 aromatic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group (with the proviso that every group except hydrogen may be substituted).
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: January 9, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: Hitoshi Harada, Osamu Asano, Masato Ueda, Shuhei Miyazawa, Yoshihiko Kotake, Yasuhiro Kabasawa, Masahiro Yasuda, Nobuyuki Yasuda
  • Publication number: 20060270674
    Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
    Type: Application
    Filed: August 9, 2006
    Publication date: November 30, 2006
    Inventors: Masahiro Yasuda, Hitoshi Harada, Shuhei Miyazawa, Seiichi Kobayashi, Kokichi Harada, Takayuki Hida, Hisashi Shibata, Nobuyuki Yasuda, Osamu Asano, Yoshihiko Kotake
  • Patent number: 7074798
    Abstract: The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, which group may be substituted; and, R1 and R2 each independently represents a hydrogen atom, an alkyl group, an alkoxyl group, or such, or salts or hydrates thereof.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: July 11, 2006
    Assignee: Eisai Co., Ltd
    Inventors: Seiji Yoshikawa, Eita Emori, Fumiyoshi Matsuura, Richard Clark, Hironori Ikuta, Nobuyuki Yasuda, Tadashi Nagakura, Kazuto Yamazaki, Mika Aoki
  • Patent number: RE39112
    Abstract: The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is —CH2CH2—, or —CH?CH— or —C?C—; R1 is: (in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.; and R5 and R6 are the same as or different from each other and each represents hydrogen atom, a lower alkyl group, a cycloalkyl group, etc.) and the like; R2 is an amino group, etc.
    Type: Grant
    Filed: December 24, 1998
    Date of Patent: May 30, 2006
    Assignee: Eisai Co., Ltd.
    Inventors: Osamu Asano, Hitoshi Harada, Yorihisa Hoshino, Seiji Yoshikawa, Takashi Inoue, Tatsuo Horizoe, Nobuyuki Yasuda, Kaya Ohashi, Junsaku Nagaoka, Manabu Murakami, Seiichi Kobayashi