Patents by Inventor Norbert Hauel

Norbert Hauel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation
    Patent number: 6727250
    Abstract: Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumor diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide, and, (2) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-4,5-dimethoxy-phenyl)-amide.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 27, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
  • Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide
    Publication number: 20040059118
    Abstract: The present invention relates to new compounds of general formula 1
    Type: Application
    Filed: July 31, 2003
    Publication date: March 25, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Norbert Hauel, Florian Colbatzky, Ulrich Busch
  • Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
    Patent number: 6710055
    Abstract: Disubstituted bicyclic heterocycles of general formula I Ra—A—Het—B—Ar—E  (I). Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: March 23, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof
    Patent number: 6660764
    Abstract: The present application relates to new carboxylic acid amides of general formula wherein A, B and R1 to R3 are defined as in claim 1, processes for preparing them, pharmaceutical compositions containing these compounds and the use thereof and their preparation.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: December 9, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
  • Benzimidazoles with antithrombotic activity
    Patent number: 6593355
    Abstract: Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, (b) 2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, and (c) (R)-2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(isobutyloxycarbonylmethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: July 15, 2003
    Assignee: Boehringer Ingelehim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20030073836
    Abstract: A compound of formula 1
    Type: Application
    Filed: July 2, 2002
    Publication date: April 17, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Norbert Hauel, Georg Dahmann, Leo Thomas, Michael Mark
  • Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production
    Publication number: 20030055263
    Abstract: The present application relates to the use of the carboxylic acid derivatives of general formula
    Type: Application
    Filed: July 10, 2002
    Publication date: March 20, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Klaus Damm, Andreas Schnapp
  • Benzimidazoles with antithrombotic activity
    Publication number: 20030004356
    Abstract: Novel benzimidazoles having antithrombotic activity.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 2, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Use of bicyclic heterocycles for the treatment and prevention of arterial thrombotic disease
    Publication number: 20020193404
    Abstract: The present invention relates to a method of treating and preventing arterial thrombotic diseases, comprising administering an effective amount of one of the compounds
    Type: Application
    Filed: May 2, 2002
    Publication date: December 19, 2002
    Inventors: Norbert Hauel, Wolfgang Wienen, Jean-Marie Stassen
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof
    Patent number: 6492547
    Abstract: The present application relates to carboxylic acid amides of general formula wherein A, B and R1 to R3 are defined as in claim 1, processes for preparing them, pharmaceutical compositions containing these compounds and the use thereof and their preparation.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: December 10, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Norbert Hauel, Klaus Damm, Andreas Schnapp
  • Substituted aryl and heteroaryl derivatives, their production and their use as medicines
    Patent number: 6479524
    Abstract: Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, (b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and (c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: November 12, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Uwe Ries, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Disubstituted bicyclic heterocycles, the preparation and the use thereof as pharmaceutical compositions
    Patent number: 6469039
    Abstract: New disubstituted bicyclic heterocycles of general formula Ra—A—Het—B—Ar—E  (I) Compounds of the above general formula I, wherein E denotes an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E denotes a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: October 22, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Benzimidazoles with antithrombotic activity
    Patent number: 6451832
    Abstract: Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, (b) 2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, and (c) (R)-2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(isobutyloxycarbonylmethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: September 17, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof
    Publication number: 20020128495
    Abstract: The present application relates to carboxylic acid amides of general formula 1
    Type: Application
    Filed: December 19, 2001
    Publication date: September 12, 2002
    Inventors: Henning Priepke, Norbert Hauel, Klaus Damm, Andreas Schnapp
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and the preparation thereof
    Publication number: 20020123509
    Abstract: The present application relates to new carboxylic acid amides of general formula 1
    Type: Application
    Filed: December 19, 2001
    Publication date: September 5, 2002
    Inventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds, their use and preparation
    Publication number: 20020099089
    Abstract: Carboxylic acid amides of general formula 1
    Type: Application
    Filed: January 3, 2002
    Publication date: July 25, 2002
    Inventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
  • Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions
    Patent number: 6414008
    Abstract: New disubstituted bicyclic heterocycles of general formula Ra—A—Het—B—Ar—E  (I) Compounds of general formula I, wherein E is an RbNH—C(═NH)— group, have valuable pharmacological properties, particularly a thrombin-inhibiting effect and the effect of prolonging thrombin time, and those wherein E is a cyano group, are valuable intermediates for preparing the other compounds of general formula I.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: July 2, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Carboxylic acid amides, pharmaceutical compositions containing these compounds and their use
    Patent number: 6362210
    Abstract: Carboxylic acid amides of general formula which inhibit telomerase and are useful for treating tumour diseases such as carcinomas, sarcomas and leukaemias. Exemplary compounds are: (1) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-phenyl)-amide, and, (2) trans-3-(naphth-2-yl)-but-2-enoic acid-N-(2-carboxy-4,5-dimethoxy-phenyl)-amide.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: March 26, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Norbert Hauel, Henning Priepke, Klaus Damm, Andreas Schnapp
  • Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments
    Publication number: 20020032238
    Abstract: The present invention relates to substituted piperazine derivatives of general formula 1
    Type: Application
    Filed: July 6, 2001
    Publication date: March 14, 2002
    Inventors: Henning Priepke, Norbert Hauel, Leo Thomas, Michael Mark, Georg Dahmann
  • Benzimidazoles with antithrombotic activity
    Publication number: 20010006977
    Abstract: Novel benzimidazoles having antithrombotic activity.
    Type: Application
    Filed: December 12, 2000
    Publication date: July 5, 2001
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen