Abstract: Provided are a heat releasing material for an electronic device being manufactured by the junction of a metal impregnated carbon composite material on a copper or aluminum substrate with reduced warpage; and a method for manufacturing the heat releasing material. A metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a metal substrate comprising a metal sheet, plate or block and, being joined on the metal substrate via a brazing material, a metal impregnated carbon composite material having a thickness of 0.1 mm to 2 mm; and a method for manufacturing the metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a step wherein a brazing material is caused to be present between the metal substrate and the metal impregnated carbon composite material, and they are kept at a temperature of 500° C. or higher and under a pressure of 0.2 MPa or more and then cooled.

Abstract: Provided are a heat releasing material for an electronic device being manufactured by the junction of a metal impregnated carbon composite material on a copper or aluminum substrate with reduced warpage; and a method for manufacturing the heat releasing material. A metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a metal substrate comprising a metal sheet, plate or block and, being joined on the metal substrate via a brazing material, a metal impregnated carbon composite material having a thickness of 0.1 mm to 2 mm; and a method for manufacturing the metal substrate/metal impregnated carbon composite material structure, characterized in that it comprises a step wherein a brazing material is caused to be present between the metal substrate and the metal impregnated carbon composite material, and they are kept at a temperature of 500° C. or higher and under a pressure of 0.2 MPa or more and then cooled.

Abstract: According to the present invention, there is provided a carbon-based metal composite material comprising a carbonaceous matrix and a metal component dispersed in said carbonaceous matrix, wherein at least 90 volume percent of the pores of the carbonaceous matrix is substituted with said metal component, and the content of said metal component is 35% or less based on the total volume of said carbon-based metal composite material; a method of producing a carbon-based metal composite material wherein impregnation of the carbon formed body with molten metal under pressure is carried out by pre-heating said carbon formed body and then impregnating the open pores of the carbon formed body with molten metal under a pressure of at least 200 kg/cm2 of the cross-sectional area of the plunger; and a substrate-shaped formed body for an electronic component comprising a carbon-based metal composite material.

Abstract: A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.

Abstract: A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.

Abstract: An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl group or an acyl group, and A is a hydroxymethyl group or an esterified or amidated carboxyl group; or its pharmaceutically acceptable salt and a pharmaceutically acceptable carrier, diluent or excipient.

Abstract: A phosphate ester of saikosaponin a, b.sub.1, b.sub.2, c, d or h or saikogenin A, C or D, or a pharmaceutically acceptable salt thereof, which exhibits potent antiinflammatory activity against adjuvant arthritis and then can be used safely as a drug for the treatment and prevention of rheumatism, and a process for preparing the same characterized by phosphorylating the saikosaponin or saikogenin.

Abstract: A retaining device having a cylindrical centering portion and a conical chucking portion for holding a bundle of optical fibers for use with a medical laser scalpel.

Abstract: A device for detecting damage in an optical fiber for transmitting high power laser beams. The optical fiber has an incident end face and an emergent end face with the emergent end face being coated with either a transmission increasing or a reflection increasing coating. A focusing optical system is provided between the laser light source and the incident end face of the optical fiber to focus the laser light reflected from the emergent end face back through the incident end face. A detector for detecting damage is disposed in path of the reflected laser light focused by the focusing optical system and outside the path of the laser light applied to the incident face.