Patents by Inventor Noriaki Yamamoto

Noriaki Yamamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11018033
    Abstract: There is provided a technique that includes a process chamber including a gate valve that opens and closes a loading and unloading port configured to load and unload a substrate, and configured to heat and process the substrate by a heater using a microwave; a substrate transfer chamber including a purge gas distribution mechanism configured to distribute a purge gas supplied from a clean unit capable of introducing the purge gas; a transfer machine installed inside the substrate transfer chamber and configured to transfer the substrate into the process chamber; and a substrate cooling mounting tool configured to cool the substrate transferred from the process chamber by the transfer machine.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 25, 2021
    Assignee: KOKUSAI ELECTRIC CORPORATION
    Inventors: Yukitomo Hirochi, Kazuhiro Yuasa, Tetsuo Yamamoto, Yoshihiko Yanagisawa, Shinya Sasaki, Noriaki Michita
  • Publication number: 20200056029
    Abstract: [Object] To provide a technology for imparting favorable slidability to fluorine rubber. [Solving Means] A composition for a sealing member includes: 100 parts by weight of an uncrosslinked fluorine rubber component; and 0.5 to 50 (inclusive) parts by weight of a particulate resin. The particulate resin includes a compatible portion and a lubrication portion, the compatible portion having compatibility with the fluorine rubber component, the lubrication portion having lubricity with respect to the fluorine rubber component. During molding of the composition for a sealing member, crosslinking of the fluorine rubber component progresses and at least a part of the particulate resin moves to a surface due to an action of the lubrication portion. As a result, a surface layer portion including a compatible portion and a lubrication portion is formed on a surface of a molded sealing member.
    Type: Application
    Filed: March 27, 2018
    Publication date: February 20, 2020
    Inventors: Shiori IRIE, Yasuhiro GUNJI, Noriaki YAMAMOTO, Hajime YANAGAWA
  • Publication number: 20200040175
    Abstract: [Object] To provide a ring-shaped sealing member having both the sealing property and slidability. [Solving Means] A sealing member is formed in a ring shape and has a sliding surface. The sealing member includes: 100 parts by weight of fluorine rubber; and 0.5 to 50 (inclusive) parts by weight of a particulate resin. The particulate resin includes a compatible portion and a lubrication portion, the compatible portion having compatibility with the fluorine rubber, the lubrication portion having lubricity with respect to the fluorine rubber. A Shore A hardness measured using the sliding surface as a pressing surface is not less than 80. In this sealing member, since rubber elasticity is achieved by the fluorine rubber, a favorable sealing property can be realized. Further, it is possible to impart high slidability to the sealing member by the action of the lubrication portion of the particulate resin. Therefore, this sealing member has both the sealing property and slidability.
    Type: Application
    Filed: March 27, 2018
    Publication date: February 6, 2020
    Inventors: Akihiro OWADA, Takashi SHINADA, Takuya OKAMOTO, Shiori IRIE, Yasuhiro GUNJI, Noriaki YAMAMOTO, Hajime YANAGAWA
  • Patent number: 10408827
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 10, 2019
    Assignees: KONICA MINOLTA LABORATORY U.S.A., INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Patent number: 10401354
    Abstract: A biosensor using a decoupled microfluidic device, which has a capture chamber and a detection chamber separate from and in fluid communication with each other. The sensing method is based on particle aggregation via homogeneous reactions, by employing microparticles having antibodies on their surfaces which can form aggregates through antigen mediation. Either size-separation or magnetic based separation is used to separate aggregates from single microparticles; the aggregates are later dissociated and the resulting single microparticles are counted to measure the amount of the antigen. Another biosensor uses a decoupled microfluidic device with a capture chamber and a detection chamber, and a 3-D structure in the capture camber to increase immobilized antibody concentration. Immunoreaction efficiency is improved by increasing the number of antibody per reaction volume in the capture chamber.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: September 3, 2019
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 10324452
    Abstract: An apparatus is configured including an information obtaining unit that extracts information on plural parts' attributes, locations, and adjoining relations with other parts; a unit that sorts parts by part type and detects a distinctive shape from 3D CAD model; a unit that represents adjoining relations between parts in an assembly graph; a unit that creates disassembling directions and a disassembling sequence based on the assembly graph and, by reversing them, derives an assembling sequence and assembling directions; a unit that computes an index indicating a quality of easiness of assembling a part by subtracting the sum of deficiency points per part from a reference score; a unit that creates virtual worker positions, postures, and viewpoints according to assembling sequence and evaluates workability; and a unit that computes an evaluation value per part by the index of easiness of assembling the part and a total evaluation value of assembly workability.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: June 18, 2019
    Assignee: HITACHI, LTD.
    Inventors: Noriaki Yamamoto, Atsuko Enomoto
  • Patent number: 10323265
    Abstract: An improved method and related apparatus for detecting bacteria viability and drug effects using metabolic monitoring. A fluorescent material which is quenched by oxygen is co-localized with the target bacteria, and fluorescence signal is detected at the co-localized places. In some embodiments, the fluorescent material is a fluorescent nanoparticle mixed with the target bacteria in the sample, and co-localization is enhanced using centrifugation, electrophoresis, microflow path modified with antibodies, magnetic force, etc. In some other embodiments, the fluorescent material is a fluorescent film or 3-D matrix immobilized in the bacterial culture chamber, and bacteria in the sample is gathered into localized regions of the bacteria culture chamber where the fluorescent film or 3-D matrix is present by ways of centrifugation, electrophoresis or microflow path. Plasmonic nanoparticles with a metal core and plasmonic film with a metal film may be used as the fluorescent nanoparticles and fluorescent film.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: June 18, 2019
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 10180425
    Abstract: A DNA ligand capable of structural changes upon binding to a target is used as a molecular switch with a SPFS (surface plasmon field-enhanced fluorescence spectroscopy) biosensor to realize one-step SPFS biosensing with rapid turnaround time. The SPFS biosensor has a thin metal film on a prism; when a light of a certain wavelength irradiates on the prism at a certain angle, a strong electrical field is generated at the surface of the metal film. The DNA is immobilized on the metal film surface with its free terminal modified with a fluorescent marker. Without the target, the DNA is folded and the fluorescent marker is located in the region of metal quenching near the metal surface. Upon binding to the target, the DNA is extended and the fluorescent marker is located in the region of enhanced electric field near the metal surface and emits a strong fluorescent signal.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: January 15, 2019
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 10010974
    Abstract: Disclosed is a technique for quickly detecting a defect of a portion welded by laser beam welding. Specifically disclosed is a welding step in which a welding device is used, the welding device welding an object to be welded with a pulsed laser. In the welding step, a first photodetector receives only infrared rays having a wavelength allowing detection of a keyhole formed in a molten pool from among infrared rays radiating from a welded portion during the welding of the object, and an analyzer determines quality of the welded portion on the basis of intensity of the infrared rays received by the first photodetector.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: July 3, 2018
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Hideo Nakamura, Tooru Sugiyama, Seiichi Matsumoto, Noriaki Yamamoto, Yoshinori Shibata
  • Publication number: 20180135094
    Abstract: An improved method and related apparatus for detecting bacteria viability and drug effects using metabolic monitoring. A fluorescent material which is quenched by oxygen is co-localized with the target bacteria, and fluorescence signal is detected at the co-localized places. In some embodiments, the fluorescent material is a fluorescent nanoparticle mixed with the target bacteria in the sample, and co-localization is enhanced using centrifugation, electrophoresis, microflow path modified with antibodies, magnetic force, etc. In some other embodiments, the fluorescent material is a fluorescent film or 3-D matrix immobilized in the bacterial culture chamber, and bacteria in the sample is gathered into localized regions of the bacteria culture chamber where the fluorescent film or 3-D matrix is present by ways of centrifugation, electrophoresis or microflow path. Plasmonic nanoparticles with a metal core and plasmonic film with a metal film may be used as the fluorescent nanoparticles and fluorescent film.
    Type: Application
    Filed: June 20, 2016
    Publication date: May 17, 2018
    Applicant: Konica Minolta Laboratory U.S.A., Inc.
    Inventor: Noriaki YAMAMOTO
  • Patent number: 9956655
    Abstract: An apparatus for generating assembly steps and an assembly sequence for sequentially assembling a product is provided with: a part detecting section for detecting designated characteristic shapes from the 3D CAD model, detecting a part present in a radial direction of each characteristic shape, and detecting a part present in an axial direction of the detected part; a section for generating a directed graph where a node denotes a part and a directed edge denotes a connection precedence relationship between parts; an assembly graph generating section for generating, an assembly graph where a node denotes a part and an edge denotes an adjacency relationship; a work order adding section for adding work contents and work orders to a list of the detected unconnected parts; and a generating section for generating the assembly sequence and an assembly direction by generating and reversely converting a disassemblable direction and a disassembly sequence.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 1, 2018
    Assignee: HITACHI, LTD.
    Inventor: Noriaki Yamamoto
  • Patent number: 9952210
    Abstract: A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner. The specimen material solution that has been sent may pass through the detection region in a repetitive manner in the case in which the micro pump sends the specimen material solution in a reciprocating manner.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: April 24, 2018
    Assignee: KONICA MINOLTA, INC.
    Inventors: Noriaki Yamamoto, Youichi Aoki
  • Patent number: 9939435
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: April 10, 2018
    Assignees: KONICA MINOLTA LABORATORY U.S.A., INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Publication number: 20180095080
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 5, 2018
    Applicants: Konica Minolta Laboratory U.S.A., Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Patent number: 9927432
    Abstract: A biosensor using a decoupled microfluidic device, which has a capture chamber and a detection chamber separate from and in fluid communication with each other. The sensing method is based on particle aggregation via homogeneous reactions, by employing microparticles having antibodies on their surfaces which can form aggregates through antigen mediation. Either size-separation or magnetic based separation is used to separate aggregates from single microparticles; the aggregates are later dissociated and the resulting single microparticles are counted to measure the amount of the antigen. Another biosensor uses a decoupled microfluidic device with a capture chamber and a detection chamber, and a 3-D structure in the capture camber to increase immobilized antibody concentration. Immunoreaction efficiency is improved by increasing the number of antibody per reaction volume in the capture chamber.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: March 27, 2018
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Publication number: 20180052157
    Abstract: A biosensor using a decoupled microfluidic device, which has a capture chamber and a detection chamber separate from and in fluid communication with each other. The sensing method is based on particle aggregation via homogeneous reactions, by employing microparticles having antibodies on their surfaces which can form aggregates through antigen mediation. Either size-separation or magnetic based separation is used to separate aggregates from single microparticles; the aggregates are later dissociated and the resulting single microparticles are counted to measure the amount of the antigen. Another biosensor uses a decoupled microfluidic device with a capture chamber and a detection chamber, and a 3-D structure in the capture camber to increase immobilized antibody concentration. Immunoreaction efficiency is improved by increasing the number of antibody per reaction volume in the capture chamber.
    Type: Application
    Filed: October 27, 2017
    Publication date: February 22, 2018
    Applicant: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki YAMAMOTO
  • Patent number: 9851350
    Abstract: A device and method for detecting and assessing the quantity of a biological, biochemical, or chemical analyte in a test sample using a simple light source and the naked eye are disclosed. In one embodiment, the device comprises a nanohole sensor chip with two sections, the first of which is a test section, upon which capture agents for a particular analyte are immobilized, and the second of which is a reference section, upon which capture agents conjugated with known quantities of the analyte are immobilized. In another embodiment of the invention, a nanohole sensor chip with a test section and a plurality of reference sections is disclosed. The sensor utilizes light intensity changes exhibited by Fano resonances in the nanoholes for detection of analytes, and allows comparison between the light intensity changes between the reference sections and the test sections for assessing the quantity of the analyte in the sample.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: December 26, 2017
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 9851330
    Abstract: A nucleic acid (NA) detection method combines ultra-specific probe, on-chip isotachophoresis (ITP) which can separate single strand and double strand NAs, and enzyme amplification. The ITP device has a sieving matrix between the LE (leading electrolyte) and TE (trailing electrolyte) reservoirs, for separating double-strand and single-strand NAs. The LE or TE reservoir also contains a spacer ion having a mobility between the LE and the TE. The sample and a double-strand NA probe is added to the TE reservoir, the probe being formed of a protector strand modified with a fluorescent molecule and a complement strand, where the protector strand is released in the presence of the target NA. Fluorescent signal is detected downstream of the sieving matrix. Alternatively, the protector strand is modified with an enzyme and a single-strand NA modified with a substrate of the enzyme is added to the reaction mixture downstream of the sieving matrix.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: December 26, 2017
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Publication number: 20170241993
    Abstract: A DNA ligand capable of structural changes upon binding to a target is used as a molecular switch with a SPFS (surface plasmon field-enhanced fluorescence spectroscopy) biosensor to realize one-step SPFS biosensing with rapid turnaround time. The SPFS biosensor has a thin metal film on a prism; when a light of a certain wavelength irradiates on the prism at a certain angle, a strong electrical field is generated at the surface of the metal film. The DNA is immobilized on the metal film surface with its free terminal modified with a fluorescent marker. Without the target, the DNA is folded and the fluorescent marker is located in the region of metal quenching near the metal surface. Upon binding to the target, the DNA is extended and the fluorescent marker is located in the region of enhanced electric field near the metal surface and emits a strong fluorescent signal.
    Type: Application
    Filed: September 1, 2015
    Publication date: August 24, 2017
    Applicant: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki YAMAMOTO
  • Publication number: 20170066092
    Abstract: An apparatus for generating assembly steps and an assembly sequence for sequentially assembling a product is provided with: a part detecting section for detecting designated characteristic shapes from the 3D CAD model, detecting a part present in a radial direction of each characteristic shape, and detecting a part present in an axial direction of the detected part; a section for generating a directed graph where a node denotes a part and a directed edge denotes a connection precedence relationship between parts; an assembly graph generating section for generating, an assembly graph where a node denotes a part and an edge denotes an adjacency relationship; a work order adding section for adding work contents and work orders to a list of the detected unconnected parts; and a generating section for generating the assembly sequence and an assembly direction by generating and reversely converting a disassemblable direction and a disassembly sequence.
    Type: Application
    Filed: January 21, 2015
    Publication date: March 9, 2017
    Applicant: HITACHI, LTD.
    Inventor: Noriaki YAMAMOTO