Abstract: An eyeglass-shaped frame includes: a pair of temples; a connecting bar connecting ends of the pair of temples; a shaft hanging from a middle of the connecting bar; nose pads fixed to the shaft; a pair of holding frames holding vertically arranged optical members; a bridge connecting the pair of holding frames; and a slider allowing the holding frames to slide vertically in front of the connecting bar. The bridge is provided at a position lower than a center of the lower optical member of the holding frames. The holding frames are slidable for a distance at least corresponding to a distance between a center of an upper optical member and the center of the lower optical member.

Abstract: In one embodiment, there is provided a charging method of a battery pack in which a plurality of aqueous battery cells are electrically connected in series. In this charging method, in a case where the battery pack reaches a reference voltage by a constant-current charging at a first charging rate, constant-current charging is performed on the battery pack at the second charging rate lower than the first charging rate and being from 0.01 C or more to 0.05 C or less. Then, this constant-current charging at the second charging rate is continued until a charged electric charge amount from a start timing of the constant-current charging at the second charging rate reaches a reference electric charge amount set from 1% or more to 5% or less of the nominal capacity of the battery pack.

Abstract: A roll paper holder includes: a blade member having a blade provided at an end of a base, a press projection provided at the other end of the base, and a convex portion provided on an upper surface of the base; a blade-member-storing case pivotally supporting the convex portion of the blade member; and a holder body to which a roll paper is attachable, in which the blade-member-storing case is mounted on an upper surface of the holder body with a base end pivotally supported by the holder body, and the blade-member-storing case has a cutout in a side thereof, the cutout being curved from a front end of the side to a lower portion of the side close to the base end of the blade-member-storing case.

Abstract: An eyeglass-shaped frame includes: a pair of lens-holding frames configured to hold lenses; a bridge connecting the pair of lens-holding frames; a temple foldably attached at a front end side thereof; a nose pad configured to support a nose in contact; movable lens-holding frames configured to be placed oppositely in front of the lens-holding frames; and a vertical movement unit configured to vertically move each of the movable lens-holding frames.

Abstract: A frame includes: a pair of temples; a connecting bar connecting respective ends of the pair of temples; at least one hanging shaft located at a middle of the connecting bar; nose pads fixed to the hanging shaft; a slide attached to the hanging shaft for a sliding movement; a pair of lens-holding frames vertically slidable in front of the connecting bar, the lens-holding frames being each configured to hold vertically arranged upper and lower lenses; and a bridge coupling the lens-holding frames. The bridge is attached at a level lower than a center of the lower lens in each of the lens-holding frames, and the lens-holding frames are slidable for a distance at least corresponding to a distance between a center of the upper lens and the center of the lower lens.

Abstract: A frame includes: a pair of lens-holding frames each holding lenses that are vertically arranged; a bridge coupling the pair of lens-holding frames; a temple attached to an outer periphery of each of the lens-holding frames; nose pads being brought into contact with a nose for support; a vertical movement unit configured to vertically move the lens-holding frames along a front bent portion of the temple; and a nose pad elevation unit provided to the bridge, the nose pad elevation unit being configured to vertically slide the nose pads. The bent portion is configured to align a center of the lens with an eye level.

Abstract: A frame includes: a pair of temples; a connecting bar connecting respective ends of the pair of temples; at least one hanging shaft located at a middle of the connecting bar; nose pads fixed to the hanging shaft; a slide attached to the hanging shaft for a sliding movement; a pair of lens-holding frames vertically slidable in front of the connecting bar, the lens-holding frames being each configured to hold vertically arranged upper and lower lenses; and a bridge coupling the lens-holding frames. The bridge is attached at a level lower than a center of the lower lens in each of the lens-holding frames, and the lens-holding frames are slidable for a distance at least corresponding to a distance between a center of the upper lens and the center of the lower lens.

Abstract: An eyeglass-shaped frame includes: a pair of temples; a connecting bar connecting ends of the pair of temples; a shaft hanging from a middle of the connecting bar; nose pads fixed to the shaft; a pair of holding frames holding vertically arranged optical members; a bridge connecting the pair of holding frames; and a slider allowing the holding frames to slide vertically in front of the connecting bar. The bridge is provided at a position lower than a center of the lower optical member of the holding frames. The holding frames are slidable for a distance at least corresponding to a distance between a center of an upper optical member and the center of the lower optical member.

Abstract: A glasses frame includes: a pair of lens-holding frames each holding vertically arranged lenses; a bridge coupling the lens-holding frames in height at the center; a temple; an inverting unit provided on an outside and in height at the center of each of the lens-holding frames and configured to invert the temple; and nose pads provided correspondingly one-to-one to both ends of the bridge and supporting the bridge while being in contact with a nose even when the lens-holding frames are inverted, in which the temple includes a bent portion.

Abstract: An eyeglass-shaped frame includes: a pair of lens-holding frames configured to hold lenses; a bridge connecting the pair of lens-holding frames; a temple foldably attached at a front end side thereof; a nose pad configured to support a nose in contact; movable lens-holding frames configured to be placed oppositely in front of the lens-holding frames; and a vertical movement unit configured to vertically move each of the movable lens-holding frames.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: A frame includes: a pair of lens-holding frames each holding lenses that are vertically arranged; a bridge coupling the pair of lens-holding frames; a temple attached to an outer periphery of each of the lens-holding frames; nose pads being brought into contact with a nose for support; a vertical movement unit configured to vertically move the lens-holding frames along a front bent portion of the temple; and a nose pad elevation unit provided to the bridge, the nose pad elevation unit being configured to vertically slide the nose pads. The bent portion is configured to align a center of the lens with an eye level.

Abstract: A glasses frame includes: a pair of lens-holding frames each holding vertically arranged lenses; a bridge coupling the lens-holding frames in height at the center; a temple; an inverting unit provided on an outside and in height at the center of each of the lens-holding frames and configured to invert the temple; and nose pads provided correspondingly one-to-one to both ends of the bridge and supporting the bridge while being in contact with a nose even when the lens-holding frames are inverted, in which the temple includes a bent portion.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: [Problem] The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. [Means for Solution] The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Abstract: To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.