Patents by Inventor Noubar B. Afeyan

Noubar B. Afeyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180030411
    Abstract: Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
    Type: Application
    Filed: October 13, 2017
    Publication date: February 1, 2018
    Inventors: Avak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
  • Publication number: 20180000910
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Application
    Filed: February 10, 2017
    Publication date: January 4, 2018
    Inventors: Tirtha CHAKRABORTY, Stephane BANCEL, Stephen G. HOGE, Atanu ROY, Antonin de FOUGEROLLES, Noubar B. AFEYAN
  • Publication number: 20170369843
    Abstract: Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
    Type: Application
    Filed: March 29, 2017
    Publication date: December 28, 2017
    Inventors: Avak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
  • Publication number: 20170165302
    Abstract: Provided are therapeutic compositions containing ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 15, 2017
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Publication number: 20170151291
    Abstract: Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 1, 2017
    Inventors: Matthew R. Henn, Kevin Daniel Litcofsky, Anthony Mario D'Onofrio, Toshiro K. Ohsumi, Mary-Jane Lombardo McKenzie, Geoffrey von Maltzahn, David N. Cook, David Arthur Berry, Noubar B. Afeyan, John Grant Aunins
  • Publication number: 20170143796
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 25, 2017
    Inventors: Jason P. SCHRUM, Stephane BANCEL, Noubar B. AFEYAN, Kenechi EJEBE
  • Patent number: 9644180
    Abstract: Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: May 9, 2017
    Assignee: RUBIUS THERAPEUTICS, INC.
    Inventors: Avak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
  • Patent number: 9597380
    Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: March 21, 2017
    Assignee: ModernaTx, Inc.
    Inventors: Tirtha Chakraborty, Stephane Bancel, Stephen G. Hoge, Atanu Roy, Antonin de Fougerolles, Noubar B. Afeyan
  • Publication number: 20170020926
    Abstract: Provided are cells containing exogenous antigen and uses thereof.
    Type: Application
    Filed: March 13, 2015
    Publication date: January 26, 2017
    Inventors: Jordi Mata-Fink, John Round, Noubar B. Afeyan, Avak Kahvejian
  • Patent number: 9533014
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: January 3, 2017
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Publication number: 20160271188
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome, e.g., gastrointestinal disorders, in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: September 22, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Shaila Rahman
  • Patent number: 9447164
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 20, 2016
    Assignee: Moderna Therapeutics, Inc.
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan, Kenechi Ejebe
  • Publication number: 20160257932
    Abstract: A genetically engineered enucleated erythroid cell comprises a phenylalanine ammonia lyase receiver polypeptide that is not associated with the membrane of the erythroid cell, produced by genetically engineering the cell by viral transduction, RNA transfection, or RNA electroporation.
    Type: Application
    Filed: May 17, 2016
    Publication date: September 8, 2016
    Inventors: Avak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
  • Publication number: 20160256572
    Abstract: Provided are formulations, compositions, kits and methods for delivering biological moieties such as modified nucleic acids into cells to induce, reduce or modulate protein expression in non-human vertebrates.
    Type: Application
    Filed: April 1, 2016
    Publication date: September 8, 2016
    Inventors: Noubar B. Afeyan, Gregory J. Sieczkiewicz, Stephane Bancel
  • Publication number: 20160243259
    Abstract: The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides formulations containing amino acids.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 25, 2016
    Inventors: Örn ALMARSSON, Noubar B. AFEYAN, Joseph Beene BOLEN, Staci SABNIS
  • Publication number: 20160235792
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: August 18, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • Publication number: 20160228506
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 24, 2014
    Publication date: August 11, 2016
    Inventors: Noubar B. Afeyan, Chung-Wei Lee, Nathaniel W. Silver, David Arthur Berry, Michael J. Hamill, David V. Erbe
  • Publication number: 20160199424
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: July 14, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Shaila Rahman
  • Publication number: 20160193258
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: July 7, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • Patent number: RE46178
    Abstract: The invention involves generating and presenting, typically electronically, a number of design alternatives to persons who are participating in the design, selection, or market research exercise. The participants (referred to as “selectors”) transmit data indicative of their preferences among or between the presented design alternatives, and that data is used to derive a new generation of design alternatives or proposals. The new designs are generated through the use of a computer program exploiting a genetic or evolutionary computational technique. The process is repeated, typically for many iterations or cycles.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: October 11, 2016
    Assignee: The Nielsen Company (US), LLC
    Inventors: Noubar B. Afeyan, Kamal M. Malek, Nigel J. Bufton, Steven G. Ficici, Howard A. Austin, Larry J. Austin, Honor E. McClellan