Publication number: 20200046625
Abstract: A peptide has the formula (I) R1—Wm—Xn-AA1-AA2-AA3-Yp—Zq—R2, where AA1 is Tyr or Trp, AA2 is Val, Ile, Leu or Met, AA3 is Tyr, Phe or Trp, W, X, Y and Z are amino acids, m, n, p and q are each 0 or 1, and m+n+p+q is less than or equal to 2. R1 is H, a polymer derived from polyethylene glycol, a non-cyclic aliphatic group, alicyclyl, heterocyclyl, heteroarylalkyl, aryl, aralkyl, or R5—CO—. R5 is H, a non-cyclic aliphatic group, alicyclyl, aryl, aralkyl, heterocyclyl or heteroarylalkyl. R2 is —NR3R4, —OR3, or —SR3. R3 and R4 are each H, a polymer derived from polyethylene glycol, a non-cyclic aliphatic group, alicyclyl, heterocyclyl, heteroarylalkyl, aryl, or aralkyl. R1 and R2 are not amino acids. Cosmetic or pharmaceutical compositions may include the peptide. It find use in reduction of lipid accumulation in the skin, treatment of cellulite, and treatment of symptoms of skin aging.
Type:
Application
Filed:
October 12, 2017
Publication date:
February 13, 2020
Applicant:
LUBRIZOL ADVANCED MATERIALS, INC.
Inventors:
Wim Van Den Nest, Nuria Almiñana Doménech, Consuelo Garcia, Antonio Vicente Ferrer Montiel
Publication number: 20200002377
Abstract: A compound has a formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-(AA7)a-(AA8)b-Yp-Zq-R2, its stereoisomers and/or its cosmetically or pharmaceutically acceptable salts, wherein: AA1 is Glu or replaced by Asp, Gln or Asn, AA2 is Glu or replaced by Asp or Gln; AA3 is Met or replaced by Leu or Ile; AA4 is Gln or replaced by Glu, Asn or Asp; AA5 is Arg or replaced by Lys; AA6 is Arg or replaced by Lys or His; AA7 is Ala, Ser, Gly, Thr, Pro, Glu, Lys, or Val; AA8 is Asp, Glu, Asn, or Gln. In the compound, no more than two of AA1, AA2, AA3, AA4, AA5 and AA6 are replaced, a and b are 0 or 1; W, X, Y and Z are amino acids; m, n, p and q are each 0 or 1; and R1 and R2 are not amino acids. A method of skin treatment with the compound is also described.
Type:
Application
Filed:
November 30, 2017
Publication date:
January 2, 2020
Applicant:
LUBRIZOL ADVANCED MATERIALS, INC.
Inventors:
Wim Van Den Nest, Katalina RODRIGUEZ BIELSA, Olga LAPORTA, Nuria GARCIA SANZ, Nuria ALMIÑANA DOMÈNECH