Patents by Inventor Oddone Schiavon
Oddone Schiavon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8546493Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— where n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: December 14, 2012Date of Patent: October 1, 2013Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Francesco M. Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 8354477Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: August 3, 2010Date of Patent: January 15, 2013Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Publication number: 20100298496Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: ApplicationFiled: August 3, 2010Publication date: November 25, 2010Applicant: Nektar TherapeuticsInventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 7786221Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: September 18, 2008Date of Patent: August 31, 2010Assignee: Nektar TherapeuticsInventors: J. Milton Harris, Francesco Maria Veronese, Paola Caliceti, Oddone Schiavon
-
Publication number: 20090054590Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: ApplicationFiled: September 20, 2008Publication date: February 26, 2009Applicant: Nektar Therapeutics AL, CorporationInventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 7419600Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: August 5, 2003Date of Patent: September 2, 2008Assignee: Nektar Therapeutics AL, CorporationInventors: J. Milton Harris, Francesco Maria Veronese, Paola Caliceti, Oddone Schiavon
-
Patent number: 7317002Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention of diagnosis of growth hormone deficiency, are also an object of the present invention.Type: GrantFiled: December 15, 2004Date of Patent: January 8, 2008Assignee: Applied Research Systems ARS Holding N.V.Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Publication number: 20050159353Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention of diagnosis of growth hormone deficiency, are also an object of the present invention.Type: ApplicationFiled: December 15, 2004Publication date: July 21, 2005Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.Inventors: Francesco Veronese, Paolo Caliceti, Oddone Schiavon
-
Publication number: 20050090650Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: ApplicationFiled: August 5, 2003Publication date: April 28, 2005Inventors: J. Harris, Francesco Veronese, Paola Caliceti, Oddone Schiavon
-
Patent number: 6869932Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys12 and/or Lys21 and/or N?, characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention or diagnosis of growth hormone deficiency, are also an object of the present invention.Type: GrantFiled: November 20, 2002Date of Patent: March 22, 2005Assignee: Applied Research Systems ARS Holding N.V.Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 6790942Abstract: Biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO—(CH2—CH2O)n—(CO)—NH—X—(CO)—NH—Z wherein R represents a lower alkyl group, n is an integer between 25 and 250, X when combined with adjcacent NH and CO groups represents a dipeptide residue, and Z when combined with the adjacent group represents a biologically active peptide or protein.Type: GrantFiled: June 5, 2001Date of Patent: September 14, 2004Assignee: Debio Recherche PharmaceutiqueInventors: Oddone Schiavon, Francesco Veronese, Paolo Caliceti, Piero Orsolini
-
Publication number: 20040029794Abstract: A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per mole of hGRF) covalently bound to Lys 12 and/or Lys 21 and/or N &agr; , characterized in that the conjugation reaction between the hGRF peptide and activated PEG is carried out in solution and the desired hGRF-PEG conjugate can be purified by chromatography. The conjugates prepared by this method, as well as their use in the treatment, prevention or diagnosis of growth hormone deficiency, are also an object of the present invention.Type: ApplicationFiled: November 20, 2002Publication date: February 12, 2004Applicant: Applied Research Systems ARS Holding N.V.Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Publication number: 20030114647Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 1Type: ApplicationFiled: April 10, 2002Publication date: June 19, 2003Applicant: Shearwater CorporationInventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 6528485Abstract: Described are various human growth hormone releasing factor-PEG conjugates as well as their pharmaceutical use.Type: GrantFiled: June 5, 2000Date of Patent: March 4, 2003Assignee: Applied Research Systems ARS Holding N.V.Inventors: Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Publication number: 20010007765Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 1Type: ApplicationFiled: August 27, 1998Publication date: July 12, 2001Inventors: J. MILTON HARRIS, FRANCESCO MARIA VERONESE, PAOLO CALICETI, ODDONE SCHIAVON
-
Patent number: 5932462Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure ##STR1## wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms poly.sub.a and poly.sub.b, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings and ester groups in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure ##STR2## where mPEG.sub.a and mPEG.sub.b have the structure CH.sub.3 O--(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- wherein n may be the same or different for mPEG.sub.a and mPEG.sub.b and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.Type: GrantFiled: May 17, 1995Date of Patent: August 3, 1999Assignee: Shearwater Polymers, Inc.Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
-
Patent number: 5631322Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein --Z--X--Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.Type: GrantFiled: June 7, 1995Date of Patent: May 20, 1997Assignee: Consiglio Nazionale delle RicercheInventors: Francesco M. Veronese, Oddone Schiavon, Paolo Caliceti, Luciana Sartore, Elisabetta Ranucci, Paolo Ferruti
-
Patent number: 5631336Abstract: A water-soluble polyvinyl 5-membered lactam having a molecular weight ranging from about 1000 to about 20,000 and chain-terminated with a compound selected from the group consisting of compounds of the following formulas ##STR1## wherein R and R.sup.1 are C.sub.1 to C.sub.4 alkyl or substituted alkyl; n is 0 to 20; R.sup.II is ethylene; R.sup.III is C.sub.1 to C.sub.24 alkylene or substituted alkylene; and R.sup.IV is C.sub.1 to C.sub.4 alkyl or substituted alkyl; can be prepared by polymerizing an N-vinyl 5-membered lactam in a liquid solvent-chain terminator compound of the formula (I) or (II) in the presence of a free radical initiator. The lactam polymer so-obtained may be activated and grafted to (conjugated with) a drug or an enzyme to alter the properties thereof.Type: GrantFiled: August 26, 1993Date of Patent: May 20, 1997Assignee: Consiglio Nazionale Delle RicercheInventors: Paolo Ferruti, Elisabetta Ranucci, Luciana Sartore, Paolo Caliceti, Oddone Schiavon, Francesco M. Veronese
-
Patent number: 5629384Abstract: Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein -Z-X-Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight ("M.sub.n ") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.Type: GrantFiled: May 17, 1994Date of Patent: May 13, 1997Assignee: Consiglio Nazionale delle RicercheInventors: Francesco M. Veronese, Oddone Schiavon, Paolo Caliceti, Luciana Sartore, Elisabetta Ranucci, Paolo Ferruti
-
Patent number: 5514572Abstract: A method for preparing protease-polyethylene glycol adducts is presented wherein the immobilized reversible inhibitor, benzamidine, prevents reaction of activated polyethylene glycol with the active site of the protease. Improved activity against macromolecular substrates is obtained compared to when the benzamidine is in solution during the conjugation reaction.Type: GrantFiled: September 19, 1994Date of Patent: May 7, 1996Assignee: Consiglio Nazionale delle RicercheInventors: Francesco Veronese, Paolo Caliceti, Oddone Schiavon, Sartore Luciana