Patents by Inventor Odile Le Martret

Odile Le Martret has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6271395
    Abstract: A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula wherein the substituents are defined as in the application having a strong affinity for optical receptors, central analgesic, diuretic, anti-arrythmic, hypotensive and cerebral anti-ischemic activity.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: August 7, 2001
    Assignee: Hoechst Marion Roussol
    Inventors: Fran├žois Clemence, Odile Le Martret, Fran├žoise Delevallee, Michel Fortin
  • Patent number: 6100404
    Abstract: Intermediates for the preparation of compounds selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## n is an integer from 3 to 5, Ar is an optionally substituted heterocyclic selected from the group consisting of
    Type: Grant
    Filed: January 9, 1997
    Date of Patent: August 8, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Constantin Agouridas, Jean-Francois Chantot, Alexis Denis, Solange Gouin D'Ambrieres, Odile Le Martret
  • Patent number: 5770579
    Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', b is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: June 23, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
  • Patent number: 5760233
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: June 2, 1998
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5674864
    Abstract: Novel .alpha.-mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: October 7, 1997
    Assignee: Roussel Uclaf
    Inventors: Fran.cedilla.ois Clemence, Odile Le Martret, Francis Petit
  • Patent number: 5656607
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: August 12, 1997
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5614614
    Abstract: Novel intermediates for the preparation of the compounds of Formula I wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: March 25, 1997
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Alain Bonnefoy, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5561118
    Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted, or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-0 ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or A is ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: October 1, 1996
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
  • Patent number: 5559130
    Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## or, if appropriate, its tautomer ##STR4## and ##STR5## or E is --COOR.sub.3 and G is ##STR6## wherein A, Y, R, Ra, R.sub.1 and R.sub.2 are as defined in the specification.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: September 24, 1996
    Assignee: Roussel Uclaf
    Inventors: Fran.cedilla.ois Clemence, Michel Fortin, Odile Le Martret
  • Patent number: 5543400
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## m and n are individually integers from 0 to 6, A and B are individually a member selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, the double bond geometry being E or Z or E+Z or A and B form a third bond between the carbon atoms to which they are attached, Ar is selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms optionally substituted with at least one member of the group consisting of free carboxy, alkoxycarbonyl, carboxy salified with a non-toxic, pharmaceutically acceptable base, amidified carboxy, --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio and alkynylthio of up to 12 carbon atoms, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms and cycloalkyl of 3 to 12 carbon atoms, all optionally substituted with at least one halogen and ##STR3## R.sub.1 and R.sub.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: August 6, 1996
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Alain Bonnefoy, Jean-Fran.cedilla.ois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5527780
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is --(CH.sub.2).sub.n --Ar.sub.1 or --XAr.sub.2, n is an integer from 1 to 6, Ar.sub.1 and Ar.sub.2 are individually selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms substituted by at least one member of the group consisting of free carboxy, alkoxy carbonyl and carboxyl salified with a pharmaceutically acceptable base, --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms optionally substituted with at least one halogen, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 12 carbon atoms, b) ##STR3## wherein R.sub.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: June 18, 1996
    Assignee: Roussel Uclaf
    Inventors: Constantin Agouridas, Alain Bonnefoy, Jean-Francois Chantot, Alexis Denis, Odile Le Martret
  • Patent number: 5444051
    Abstract: Compounds of the formula ##STR1## wherein X and X' form C.dbd.O or C.dbd.NOR, R is selected from the group consisting of hydrogen, heterocycle, alkyl, alkenyl, alkynyl, all optionally substituted,or X is ##STR2## R.sub.a and R.sub.b are hydrogen or a hydrocarbon group or form together with the nitrogen a heterocycle, or with A forms a 9-N, 11-O ring, and X' is hydrogen, --Y and Y' have the same definition as X and X', B is hydrogen or OR.sub.4, R.sub.4 is hydrogen or forms together with A a carbonate or a carbamate, A forms with C a double bond or A is OR'.sub.4, R'.sub.4 is hydrogen or forms together with B a carbonate or ##STR3## R.sub.2 is alkyl or --CONH.sub.2, --CONHCOR.sub.11 or --CONHSO.sub.2 R.sub.11, R.sub.11 is a hydrocarbon up to 18 carbon atoms, R.sub.3 is hydrogen, ##STR4## and Z is hydrogen or a carboxylic acid remainder and their non-toxic, pharmaceutically acceptable acid addition salts, their preparation and intermediates useful as antibiotics.
    Type: Grant
    Filed: June 28, 1993
    Date of Patent: August 22, 1995
    Assignee: Roussel UCLAF
    Inventors: Constantin Agouridas, Yannick Benedetti, Jean-Francois Chantot, Alexis Denis, Claude Fromentin, Odile Le Martret
  • Patent number: 5436244
    Abstract: Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substituents are as defined in the specification and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates having central analgesic properties as well as antiarrhythmic and diuretic activities.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: July 25, 1995
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Gilles Hamon, Odile Le Martret, Anne M. Moura
  • Patent number: 5395843
    Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## wherein A, R, R.sub.1, R.sub.2 and Y are as defined in the specification.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: March 7, 1995
    Assignee: Roussel-Uclaf
    Inventors: Francois Clemence, Michel Fortin, Odile Le Martret
  • Patent number: 5356907
    Abstract: A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein E and G together form a group selected from the group: ##STR2## consisting of a) ##STR3## wherein, A is a cycloalkyl of 3-6 carbon optionally substituted, R, R.sub.1, R.sub.2 and Y are defined in the specification.
    Type: Grant
    Filed: October 1, 1992
    Date of Patent: October 18, 1994
    Assignee: Roussel UCLAF
    Inventors: Francois Clemence, Michel Fortin, Odile Le Martret
  • Patent number: 5348971
    Abstract: Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substrates are as defined in the application and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates are disclosed as having central analgesic properties as well as antiarrhythmic and diuretic activities.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: September 20, 1994
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Gilles Hamon, Odile Le Martret, Anne-Marie Moura
  • Patent number: 5254566
    Abstract: A compound selected from the group consisting of racemates, enantiomeric and diastereoisomeric forms of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms optionally substituted with at least one halogen, hydroxy, alkyl or alkoxy of 1 to 4 carbon atoms or taken together with the nitrogen to which they are attached form a heterocycle optionally containing a heteroatom selected from the group consisting of --O--, --S-- and nitrogen optionally substituted with alkyl or alkoxy of 1 to 5 carbon atoms, optionally substituted benzyl and phenyl, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, halogen, hydroxy and alkyl and alkoxy of 1 to 5 carbon atoms optionally substituted with at least one substituent selected from the group consisting of halogen, hydroxy, phenyl and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: October 19, 1993
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Gilles Hamon, Odile Le Martret
  • Patent number: 5234944
    Abstract: A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1## wherein R.sub.6 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the carbon atoms to which they are attached form a cycloalkyl of 3 to 6 carbon atoms optionally containing a heteroatom selected from the group consisting of --S--, --O-- and --N--, one of A and B has the formula ##STR2## and the other has the formula ##STR3## R is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of --(CH.sub.2).sub.n --, branched alkylene of 2 to 8 carbon atoms and --CH.sub.2 O--, n is an integer of 0 to 5, X, X' and X" are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 4 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: August 10, 1993
    Assignee: Roussel UCLAF
    Inventors: Francois Clemence, Odile Le Martret, Francoise Delevallee, Michel Fortin
  • Patent number: 5190974
    Abstract: Novel .alpha.-mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein n, R.sub.1, R.sub.2, X, A, R.sub.3A and R.sub.4A are set forth in the claims and their non-toxic, pharmaceutically acceptable acid addition salts having excellent analgesic, psychotropic and enkephalinase inhibiting properties.
    Type: Grant
    Filed: July 5, 1991
    Date of Patent: March 2, 1993
    Assignee: Roussel Uclaf
    Inventors: Francoise Clemence, Odile Le Martret, Francis Petit
  • Patent number: 5043347
    Abstract: A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1##
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: August 27, 1991
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Odile Le Martret, Francoise Delevallee, Michel Fortin