Patents by Inventor Ofer A. Goren

Ofer A. Goren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200214958
    Abstract: Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells.
    Type: Application
    Filed: January 21, 2020
    Publication date: July 9, 2020
    Inventors: Ofer A. Goren, John McCoy
  • Publication number: 20200140952
    Abstract: Described herein are compositions and methods for the prediction of bladder cancer risk of invasiveness. The compositions are microRNA molecules associated with the prognosis of bladder cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.
    Type: Application
    Filed: May 3, 2019
    Publication date: May 7, 2020
    Applicant: ROSETTA GENOMICS LTD.
    Inventors: Ofer Nativ, Yaron Goren
  • Patent number: 10633688
    Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay for sulfotransferase activity. In particular, SULT1A1 activity may be used as an indicator of minoxidil response. A genetic test for alleles of the SULT1A1 gene may be performed to provide a more personalized therapy.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 28, 2020
    Assignee: Follea International
    Inventors: Ofer A. Goren, John McCoy, Philip Y. Tam
  • Publication number: 20200094071
    Abstract: Embodiments of the system include a therapeutic device configured to generate electromagnetic radiation (EMR) for treatment of androgenetic alopecia. Embodiments of the therapeutic device can be configured to generate EMR having a wavelength within a therapeutic range of wavelengths, the EMR being able to stimulate opsin receptors located in keratinocytes and/or hair follicles so as to cause the stimulated opsin receptors to grow hair and/or promote hair follicle stem cell differentiation and/or proliferation. The therapeutic device can be a unit that is attachable to and communication with a mobile electronic device (e.g., a mobile phone, a tablet, etc.). Data related to the therapy session can be collected and analyzed by the mobile electronic device to provide diagnostic results of the therapy session.
    Type: Application
    Filed: September 25, 2019
    Publication date: March 26, 2020
    Inventor: Ofer A. Goren
  • Publication number: 20200060997
    Abstract: The present invention discloses compositions, methods, and systems of treating female sexual dysfunction by stimulating the contraction of the smooth muscle of the nipple. The smooth muscle in the nipple expresses trace amine associated receptors and thus can be contracted through a class of trace amine associated receptor agonists such as octopamine or tyramine, but any agent that promotes contraction of smooth muscle can be considered for the methods and compositions described herein. The contraction of the smooth muscle erects the nipple and increases female sexual arousal. The smooth muscle stimulatory compound can be formulated in a solution, foam, ointment, gel, spray, lotion, powder, topical cream, emulsion, slow release capsule or any similar method, compound, or delivery vehicle including a pre-wetted gauze or cotton pad. Additionally, the disclosed composition can be used to improve the quality of a sexual experience, e.g.
    Type: Application
    Filed: August 27, 2019
    Publication date: February 27, 2020
    Inventors: Ofer A. Goren, John McCoy
  • Patent number: 10357452
    Abstract: Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of a therapeutic agent such as an alpha-1 adrenergic receptor agonist to the nipple-areola complex are disclosed.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: July 23, 2019
    Assignee: Rejoy
    Inventors: Ofer A. Goren, John McCoy
  • Publication number: 20190110968
    Abstract: Disclosed herein are compositions of synephrine and a penetration enhancer and methods of reducing hair loss from pulling by applying the compositions. In one embodiment, the composition is a prewash composition comprising water, synephrine, and PEG-6 caprylic/capric glycerides.
    Type: Application
    Filed: July 16, 2018
    Publication date: April 18, 2019
    Applicant: Follea International
    Inventors: John McCoy, Ofer A. Goren
  • Patent number: 10238593
    Abstract: Traction alopecia and other disorders related to mechanical pulling on hair are treated or prevented by administering a topical composition comprising an alpha-1 adrenergic receptor agonist or another compound or electrical stimulation to contract the arrector pili muscle.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: March 26, 2019
    Assignee: Follea International
    Inventors: Ofer A. Goren, John McCoy
  • Publication number: 20190038575
    Abstract: Disclosed herein are compositions including a topical agent that may be used to reduce and/or inhibit the effects of chemotherapy and/or radiotherapy, which can include reducing and/or inhibiting the effects of hair loss and/or hair shedding due to chemotherapy and/or radiotherapy. The topical agent can be a weak acting alpha-1 adrenergic receptor agonist such as synephrine. Some embodiments of the composition can include a weak acting alpha-1 adrenergic receptor agonist with a modulating agent to modulate deposition, mode of action, and/or metabolism of a chemotherapeutic agent and/or a reactive oxygen species agent.
    Type: Application
    Filed: August 1, 2018
    Publication date: February 7, 2019
    Inventors: Ofer A. Goren, John McCoy
  • Patent number: 10111821
    Abstract: Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength range. Uses may include the treatment of such conditions as psoriasis, vitiligo, pruritus, acne, vitamin-D deficiency and atopic dermatitis. Topical creams, sprays, or other compositions may be used, with or without dosimeters, or in conjunction with an application, which calculates local UV exposure and other factors relating to dosage.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: October 30, 2018
    Assignee: Applied Biology, Inc.
    Inventors: Andy Ofer Goren, John McCoy
  • Publication number: 20180296471
    Abstract: Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of a therapeutic agent such as an alpha-1 adrenergic receptor agonist to the nipple-areola complex are disclosed.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 18, 2018
    Applicant: ReJoy
    Inventors: Ofer A. Goren, John McCoy
  • Patent number: 10064816
    Abstract: Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of a therapeutic agent such as an alpha-1 adrenergic receptor agonist to the nipple-areola complex are disclosed.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 4, 2018
    Assignee: Rejoy
    Inventors: Ofer A. Goren, John McCoy
  • Publication number: 20180078499
    Abstract: Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of a therapeutic agent such as an alpha-1 adrenergic receptor agonist to the nipple-areola complex are disclosed.
    Type: Application
    Filed: June 10, 2016
    Publication date: March 22, 2018
    Applicant: Rejoy
    Inventors: Ofer A. Goren, John McCoy
  • Publication number: 20170333316
    Abstract: Traction alopecia and other disorders related to mechanical pulling on hair are treated or prevented by administering a topical composition comprising an alpha-1 adrenergic receptor agonist or another compound or electrical stimulation to contract the arrector pili muscle.
    Type: Application
    Filed: November 13, 2015
    Publication date: November 23, 2017
    Applicant: FOLLEA INTERNATIONAL
    Inventors: Ofer A. GOREN, John MCCOY
  • Publication number: 20170165253
    Abstract: Compositions and methods for treating sexual dysfunction and enhancing sexual satisfaction using topical application of alpha-1 adrenergic receptor agonists, muscarinic acetylcholine receptor agonists, nicotinic acetylcholine receptor agonists, and cholinesterase inhibitors are disclosed.
    Type: Application
    Filed: November 17, 2016
    Publication date: June 15, 2017
    Applicant: ReJoy
    Inventors: Ofer A. GOREN, John McCoy
  • Publication number: 20170135988
    Abstract: Traction alopecia and other disorders related to mechanical pulling on hair are treated or prevented by administering a topical composition comprising an alpha-1 adrenergic receptor agonist, a muscarinic receptor agonist, a nicotinic receptor agonist, and/or a cholinesterase inhibitor, or electrical stimulation to contract the arrector pili muscle. Compositions and methods are disclosed herein for the treatment and prevention of hair loss disorders caused at least in part by repeated application of tensile force to hair, including, without limitation, traction alopecia.
    Type: Application
    Filed: November 17, 2016
    Publication date: May 18, 2017
    Inventors: Ofer A. GOREN, John MCCOY
  • Patent number: 9588118
    Abstract: Apparatuses are disclosed for performing calorimetric assays with plucked human hair using a device adapted for that purpose. This device may include a transparent reaction vessel connected via a capillary tube to a burst pack, and connected via another capillary tube to a funnel, into which a plucked human hair may be placed.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: March 7, 2017
    Assignee: Follea International
    Inventors: Andy Ofer Goren, John McCoy, Daniel Hafid
  • Publication number: 20160220465
    Abstract: Disclosed herein are cosmetically pleasing topic al formulations of minoxidil and methods of inducing hair growth. The minoxidil is at a concentration of 2%-20% by weight in the formulations. In one embodiment, the aerosol formulation comprises a sebum absorber such as a modified starch.
    Type: Application
    Filed: December 31, 2015
    Publication date: August 4, 2016
    Applicant: APPLIED BIOLOGY, INC.
    Inventors: Ofer A. GOREN, John MCCOY
  • Publication number: 20140335537
    Abstract: Apparatuses are disclosed for performing calorimetric assays with plucked human hair using a device adapted for that purpose. This device may include a transparent reaction vessel connected via a capillary tube to a burst pack, and connected via another capillary tube to a funnel, into which a plucked human hair may be placed.
    Type: Application
    Filed: April 7, 2014
    Publication date: November 13, 2014
    Applicant: Follea International Ltd.
    Inventors: Andy Ofer Goren, John McCoy, Daniel Hafid
  • Publication number: 20140309247
    Abstract: Methods, processes, systems, and apparatuses are disclosed for detecting biomarkers associated with the inflammation response in the pilosebaceous unit of the human scalp using plucked human hair and an enzyme activity assay which may for example be colorimetric or fluorometric.
    Type: Application
    Filed: April 15, 2013
    Publication date: October 16, 2014
    Inventors: Andy Ofer Goren, John McCoy