Patents by Inventor Oivin Guicherit

Oivin Guicherit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small organic molecule regulators of cell proliferation
    Patent number: 8852937
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: October 7, 2014
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 8772275
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: July 8, 2014
    Assignee: Curis, Inc.
    Inventors: Lee L. Rubin, Oivin Guicherit, Stephen Price, Edward Andrew Boyd
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 8354397
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: January 15, 2013
    Assignee: Curis, Inc.
    Inventors: Lee L. Rubin, Oivin Guicherit, Stephen Price, Edward Andrew Boyd
  • Small organic molecule regulators of cell proliferation
    Patent number: 8129425
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: March 6, 2012
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Small organic molecule regulators of cell proliferation
    Publication number: 20080207740
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: August 20, 2007
    Publication date: August 28, 2008
    Applicant: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 7300929
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: November 27, 2007
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin Guicherit, Stephen Price, Lee L. Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20070021493
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Application
    Filed: April 19, 2006
    Publication date: January 25, 2007
    Applicant: Curis, Inc.
    Inventors: Oivin Guicherit, Lee Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20060287385
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: April 27, 2006
    Publication date: December 21, 2006
    Inventors: Anthony Baxter, Edward Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Stibbard
  • Small organic molecule regulators of cell proliferation
    Patent number: 7115653
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: October 3, 2006
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee L. Rubin, John Harry Alexander Stibbard
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050085519
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: July 29, 2002
    Publication date: April 21, 2005
    Inventors: Lee Rubin, Oivin Guicherit, Stephen Price, Edward Boyd
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050080138
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Application
    Filed: September 29, 2004
    Publication date: April 14, 2005
    Applicant: Curis, Inc.
    Inventors: Oivin Guicherit, Lee Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20050014796
    Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: December 9, 2003
    Publication date: January 20, 2005
    Applicant: Curis, Inc.
    Inventors: Anthony Baxter, Edward Boyd, Oivin Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Publication number: 20040023949
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
    Type: Application
    Filed: April 4, 2003
    Publication date: February 5, 2004
    Applicant: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin Guicherit, Stephen Price, Lee L. Rubin
  • Small organic molecule regulators of cell proliferation
    Publication number: 20030139457
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Application
    Filed: September 17, 2002
    Publication date: July 24, 2003
    Applicant: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Maria Frank-Kamenetsky, Oivin Guicherit, Jeffery Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard