Patents by Inventor Olaf Grassmann

Olaf Grassmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100311971
    Abstract: The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    Type: Application
    Filed: July 22, 2010
    Publication date: December 9, 2010
    Inventors: Andre Bubendorf, Annette Deynet-Vucenovic, Ralph Diodone, Olaf Grassmann, Kai Lindenstruth, Emmanuel Pinard, Franziska E. Rohrer, Urs Schwitter
  • Patent number: 7772264
    Abstract: The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: August 10, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Abrecht, Andre Gerard Bubendorf, Stephan Goetzoe, Olaf Grassmann, Francois Montavon, Regina Moog, Franziska Rohrer, Armin Ruf, Michelangelo Scalone, Urs Schwitter, Shaoning Wang
  • Publication number: 20100093808
    Abstract: The invention is concerned with (2S)-1-{[1,1-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Inventors: André Bubendorf, Olaf Grassmann, Daniel Hunziker, Holger Kuehne, Regina Moog, Urs Schwitter
  • Publication number: 20100068100
    Abstract: Some embodiments of the present disclosure include a sample carrier for biologically active samples, in particular for toxic samples and especially for highly toxic samples. Such embodiments include a bottom part, a first membrane, a spacer, a second membrane and a lid. The bottom part and the lid may be connectable such that the first membrane, the spacer and the second membrane are enclosed between the bottom part and the lid. The bottom part and the lid may include means for a non-detachable form-locking connection between the bottom part and the lid.
    Type: Application
    Filed: August 20, 2009
    Publication date: March 18, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Dieter Voegelin, Olaf Grassmann
  • Publication number: 20090215826
    Abstract: The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine-3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 27, 2009
    Inventors: Jean-Michel Adam, Andre Bubendorf, Annette Deynet-Vucenovic, Pascal Dott, Alexander Glomme, Olaf Grassmann, Wolfgang Haap, Martin Kuentz, Roland Meier
  • Publication number: 20090176886
    Abstract: The present invention relates to polymorphic forms of (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester phosphate, which is a potent inhibitor of viral neuraminidase.
    Type: Application
    Filed: December 19, 2008
    Publication date: July 9, 2009
    Inventors: Andre Bubendorf, Pierre Goldbach, Olaf Grassmann, Michael Henning, Ines Sauer, Rene Trussardi
  • Publication number: 20080312288
    Abstract: The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine.
    Type: Application
    Filed: December 17, 2007
    Publication date: December 18, 2008
    Inventors: Thomas Cleary, Alexander Glomme, Olaf Grassmann, Shan-Ming Kuang, Roland Meier, Doreen Miller, Regina Moog, Franziska E. Rohrer, Jason Yang
  • Publication number: 20080214561
    Abstract: The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    Type: Application
    Filed: December 19, 2007
    Publication date: September 4, 2008
    Inventors: Andre Bubendorf, Annette Deynet-Vucenovic, Ralph Diodone, Olaf Grassmann, Kai Lindenstruth, Emmanuel Pinard, Franziska E. Rohrer, Urs Schwitter
  • Patent number: 7409041
    Abstract: Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: August 5, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Olaf Grassmann, Michael Hennig, Remo Anton Hochstrasser, Urs Schwitter
  • Publication number: 20070142436
    Abstract: The invention is concerned with (2S)-1-{[1,1 -Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
    Type: Application
    Filed: December 14, 2006
    Publication date: June 21, 2007
    Inventors: Andre Bubendorf, Olaf Grassmann, Daniel Hunziker, Holger Kuehne, Regina Moog, Urs Schwitter
  • Publication number: 20060245544
    Abstract: Methods for transmission mode X-ray diffraction analysis of a sample by means of apparatuses comprising an X-ray radiation source that provides X-ray radiation for irradiating the sample and a detector for detecting X-ray radiation transmitted through and diffracted by the sample. The methods include: (a) placing a sample to be analyzed on a substrate, (b) generating X-ray radiation by means of an X-ray radiation source, (c) positioning the substrate and the sample in an initial position, (d) rotating the substrate and the sample with respect to the initial position around a rotation axis over a predetermined rotation angle, (e) tilting the substrate and the sample with respect to the initial position around a tilting axis over a tilting angle, (f) detecting with a detector the X-ray radiation transmitted through and diffracted by the sample during a time interval, and (g) analyzing the X-ray radiation that is detected.
    Type: Application
    Filed: May 2, 2006
    Publication date: November 2, 2006
    Inventors: Olaf Grassmann, Michael Hennig, Remo Hochstrasser, Urs Schwitter
  • Publication number: 20060217428
    Abstract: The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
    Type: Application
    Filed: March 16, 2006
    Publication date: September 28, 2006
    Inventors: Stefan Abrecht, Andre Bubendorf, Stephan Goetzoe, Olaf Grassmann, Francois Montavon, Regina Moog, Franziska Rohrer, Armin Ruf, Michelangelo Scalone, Urs Schwitter, Shaoning Wang