Patents by Inventor Oleg Melnyk
Oleg Melnyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10435450Abstract: Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.Type: GrantFiled: January 21, 2016Date of Patent: October 8, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITA' DEGLI STUDI DI PAVIA, UNIVERSITÉ DE LILLEInventors: Jerome Vicogne, Oleg Melnyk, Nathalie Ollivier, Eric Adriaenssens, Berenice Leclercq, Claire Simonneau, Giovanni De Nola, Ermanno Gherardi, Hugo De Jonge
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Patent number: 10072041Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An??(I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.Type: GrantFiled: February 15, 2012Date of Patent: September 11, 2018Assignees: Centre National de la Recherche Scientifique, Universite de Lille 1 Sciences et TechnologiesInventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
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MULTIMERIC COMPOUNDS OF A KRINGLE DOMAIN FROM THE HEPATOCYTE GROWTH FACTOR / SCATTER FACTOR (HGF/SF)
Publication number: 20180008723Abstract: Disclosed are multimeric compounds of K1 domains from the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) being able to induce activation of the tyrosine kinase receptor MET and their uses.Type: ApplicationFiled: January 21, 2016Publication date: January 11, 2018Inventors: Jerome VICOGNE, Oleg MELNYK, Nathalie OLLIVIER, Eric ADRIAENSSENS, Berenice LECLERCQ, Claire SIMONNEAU, Giovanni DE NOLA, Ermanno GHERARDI, Hugo DE JONGE -
Publication number: 20170369545Abstract: Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.Type: ApplicationFiled: January 21, 2016Publication date: December 28, 2017Inventors: Jerome VICOGNE, Oleg MELNYK, Nathalie OLLIVIER, Eric ADRIAENSSENS, Berenice LECLERCQ, Claire SIMONNEAU, Giovanni DE NOLA, Ermanno GHERARDI, Hugo DE JONGE
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Patent number: 9796758Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.Type: GrantFiled: March 18, 2013Date of Patent: October 24, 2017Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTEInventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
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Patent number: 9671397Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.Type: GrantFiled: October 11, 2011Date of Patent: June 6, 2017Assignees: Centre National De La Recherche Scientifique, Innobiochips, Universite De Lille 2 Droit Et Sante, Universite De Lille 1 Sciences Et TechnologiesInventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
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Publication number: 20160003836Abstract: The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.Type: ApplicationFiled: February 17, 2014Publication date: January 7, 2016Inventors: JONATHAN STAUBER, JEAN-PHILIPPE EBRAN, OLEG MELNYK
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Patent number: 9206224Abstract: Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. The invention also relates to kits for applying this synthesis method as well as test and/or diagnostic kits.Type: GrantFiled: October 16, 2012Date of Patent: December 8, 2015Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Oleg Melnyk, Laurent Raibaut, Vincent Aucagne, Agnes Delmas
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Patent number: 9029503Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.Type: GrantFiled: October 28, 2010Date of Patent: May 12, 2015Assignees: Centre National de la Recherche Scientifique, Institut Pasteur de LilleInventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
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Publication number: 20150045506Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.Type: ApplicationFiled: March 18, 2013Publication date: February 12, 2015Applicants: UNIVERSITE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLEInventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
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Publication number: 20140256879Abstract: Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. Kits for applying this synthesis method as well as test and/or diagnostic kits are also described.Type: ApplicationFiled: October 16, 2012Publication date: September 11, 2014Inventors: Oleg Melnyk, Laurent Raibaut, Vincent Aucagne, Agnes Delmas
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Publication number: 20130331545Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An ??(I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.Type: ApplicationFiled: February 15, 2012Publication date: December 12, 2013Applicants: UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
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Publication number: 20130203629Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.Type: ApplicationFiled: October 11, 2011Publication date: August 8, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INNOBIOCHIPSInventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
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Publication number: 20120220721Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.Type: ApplicationFiled: October 28, 2010Publication date: August 30, 2012Applicants: Institut Pasteur de Lille, Centre National de la Recherche Scientifique (CNRS)Inventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
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Patent number: 8178474Abstract: The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one ?-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one ?-oxoaldehyde function and to the ?-oxoaldehyde peptides obtained using this process.Type: GrantFiled: July 15, 2002Date of Patent: May 15, 2012Assignees: Institut Pasteur de Lille, Centre National de la Recherche Scientifique CNRSInventors: Oleg Melnyk, Jean-Sebastien Fruchart, Line Bourel, Helene Gras-Masse
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Patent number: 7390875Abstract: The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.Type: GrantFiled: September 7, 2001Date of Patent: June 24, 2008Assignee: Institut Pasteur de LilleInventors: Dominique Bonnet, Line Bourel, Oleg Melnyk, Hélène Gras-Masse
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Publication number: 20070243623Abstract: The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.Type: ApplicationFiled: May 15, 2003Publication date: October 18, 2007Applicants: Sedac Therapeutics, Centre National De La Recherche Scientifique, Universite De Lille 2Inventors: Oleg Melnyk, Xavier Duburcq, Helene Gras-Masse, Christophe Olivier, Fengling Zhou, Claude Auriault, Ahmed Bouzidi
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Publication number: 20040235049Abstract: The invention concerns a device for presentation of peptides or of proteins, which can be used as a “polypeptide chip” for the miniaturised detection of molecules structurally or functionally complementary to the said polypeptides. This device consists of a flat support onto which the polypeptides are covalently bonded, this bonding between the polypeptides and the support resulting from the formation of a semicarbazone bond. The semicarbazone bond results in particular from the reaction between polypeptides bearing an aldehyde or ketone function and a support functionalised with semicarbazide groups. The invention also concerns the process for preparation of the supports and for attaching polypeptides onto these supports and also the use of the devices thus obtained as polypeptide chips.Type: ApplicationFiled: June 28, 2004Publication date: November 25, 2004Inventors: Oleg Melnyk, Helene Gras-Masse, Christophe Olivier, Jean-Olivier Durand, Claude Auriault, Xavier Duburco, Ahmed Bouzidi, Jean-Michel Garcia, Ouafaa El-Mahdi
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Publication number: 20040092015Abstract: The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.Type: ApplicationFiled: May 13, 2003Publication date: May 13, 2004Inventors: Dominique Bonnet, Line Bourel, Oleg Melnyk, Helene Gras-Masse
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Publication number: 20030162185Abstract: The invention concerns products comprising a support whereon are fixed nucleic acids and their preparation method and use as DNA support. The invention also concerns functionalised supports, oligonucleotides and DNA's modified in position 5′ by a group selected in the group consisting of tartaric acid, serine, threonine, their derivatives and the &agr;-oxoaldehyde group, and the methods for preparing them. The invention further concerns a method for fixing a nucleic acid on a support.Type: ApplicationFiled: October 10, 2002Publication date: August 28, 2003Inventors: Oleg Melnyk, Christophe Olivier, Nathalie Ollivier, David Hot, Ludovic Huot, Yves Lemoine, Isabelle Wolowczuk, Tam Huynh-Dinh, Catherine Gouyette, Helene Gras-Masse