Patents by Inventor Oleg Melnyk

Oleg Melnyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10435450
    Abstract: Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: October 8, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITA' DEGLI STUDI DI PAVIA, UNIVERSITÉ DE LILLE
    Inventors: Jerome Vicogne, Oleg Melnyk, Nathalie Ollivier, Eric Adriaenssens, Berenice Leclercq, Claire Simonneau, Giovanni De Nola, Ermanno Gherardi, Hugo De Jonge
  • Patent number: 10072041
    Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An??(I) in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: September 11, 2018
    Assignees: Centre National de la Recherche Scientifique, Universite de Lille 1 Sciences et Technologies
    Inventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
  • Publication number: 20180008723
    Abstract: Disclosed are multimeric compounds of K1 domains from the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) being able to induce activation of the tyrosine kinase receptor MET and their uses.
    Type: Application
    Filed: January 21, 2016
    Publication date: January 11, 2018
    Inventors: Jerome VICOGNE, Oleg MELNYK, Nathalie OLLIVIER, Eric ADRIAENSSENS, Berenice LECLERCQ, Claire SIMONNEAU, Giovanni DE NOLA, Ermanno GHERARDI, Hugo DE JONGE
  • Publication number: 20170369545
    Abstract: Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.
    Type: Application
    Filed: January 21, 2016
    Publication date: December 28, 2017
    Inventors: Jerome VICOGNE, Oleg MELNYK, Nathalie OLLIVIER, Eric ADRIAENSSENS, Berenice LECLERCQ, Claire SIMONNEAU, Giovanni DE NOLA, Ermanno GHERARDI, Hugo DE JONGE
  • Patent number: 9796758
    Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: October 24, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT PASTEUR DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTE
    Inventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
  • Patent number: 9671397
    Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 6, 2017
    Assignees: Centre National De La Recherche Scientifique, Innobiochips, Universite De Lille 2 Droit Et Sante, Universite De Lille 1 Sciences Et Technologies
    Inventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
  • Publication number: 20160003836
    Abstract: The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.
    Type: Application
    Filed: February 17, 2014
    Publication date: January 7, 2016
    Inventors: JONATHAN STAUBER, JEAN-PHILIPPE EBRAN, OLEG MELNYK
  • Patent number: 9206224
    Abstract: Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. The invention also relates to kits for applying this synthesis method as well as test and/or diagnostic kits.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: December 8, 2015
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Oleg Melnyk, Laurent Raibaut, Vincent Aucagne, Agnes Delmas
  • Patent number: 9029503
    Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: May 12, 2015
    Assignees: Centre National de la Recherche Scientifique, Institut Pasteur de Lille
    Inventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
  • Publication number: 20150045506
    Abstract: A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Applicants: UNIVERSITE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE
    Inventors: Oleg Melnyk, Laurent Raibaut, Nathalie Ollivier
  • Publication number: 20140256879
    Abstract: Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. Kits for applying this synthesis method as well as test and/or diagnostic kits are also described.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 11, 2014
    Inventors: Oleg Melnyk, Laurent Raibaut, Vincent Aucagne, Agnes Delmas
  • Publication number: 20130331545
    Abstract: Method for preparing a peptide assembly of n fragments and n?1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci?1-Ai- . . . -Cn?1-An ??(I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci?1 . . . Cn?1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.
    Type: Application
    Filed: February 15, 2012
    Publication date: December 12, 2013
    Applicants: UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Oleg Melnyk, Nathalie Ollivier, Reda Mhidia, Julien Dheur
  • Publication number: 20130203629
    Abstract: The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 8, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIES, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INNOBIOCHIPS
    Inventors: Oleg Melnyk, Jean-Philippe Georges Bernard Ebran, Julien Philippe Dheur, Nabil Dendane, Vianney Souplet, Christophe Olivier
  • Publication number: 20120220721
    Abstract: The invention mainly relates to a method for manufacturing a polypeptide of formula: X1—X?—X2??(III) X1 and X2 each representing a peptide fragment, and X? representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula: X1—N(CH2CH2SH)2??(I) and a polypeptide of formula: H—X?—X2.??(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.
    Type: Application
    Filed: October 28, 2010
    Publication date: August 30, 2012
    Applicants: Institut Pasteur de Lille, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Oleg Melnyk, Reda Mhidia, Julien Dheur, Nathalie Ollivier
  • Patent number: 8178474
    Abstract: The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one ?-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one ?-oxoaldehyde function and to the ?-oxoaldehyde peptides obtained using this process.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: May 15, 2012
    Assignees: Institut Pasteur de Lille, Centre National de la Recherche Scientifique CNRS
    Inventors: Oleg Melnyk, Jean-Sebastien Fruchart, Line Bourel, Helene Gras-Masse
  • Patent number: 7390875
    Abstract: The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: June 24, 2008
    Assignee: Institut Pasteur de Lille
    Inventors: Dominique Bonnet, Line Bourel, Oleg Melnyk, Hélène Gras-Masse
  • Publication number: 20070243623
    Abstract: The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.
    Type: Application
    Filed: May 15, 2003
    Publication date: October 18, 2007
    Applicants: Sedac Therapeutics, Centre National De La Recherche Scientifique, Universite De Lille 2
    Inventors: Oleg Melnyk, Xavier Duburcq, Helene Gras-Masse, Christophe Olivier, Fengling Zhou, Claude Auriault, Ahmed Bouzidi
  • Publication number: 20040235049
    Abstract: The invention concerns a device for presentation of peptides or of proteins, which can be used as a “polypeptide chip” for the miniaturised detection of molecules structurally or functionally complementary to the said polypeptides. This device consists of a flat support onto which the polypeptides are covalently bonded, this bonding between the polypeptides and the support resulting from the formation of a semicarbazone bond. The semicarbazone bond results in particular from the reaction between polypeptides bearing an aldehyde or ketone function and a support functionalised with semicarbazide groups. The invention also concerns the process for preparation of the supports and for attaching polypeptides onto these supports and also the use of the devices thus obtained as polypeptide chips.
    Type: Application
    Filed: June 28, 2004
    Publication date: November 25, 2004
    Inventors: Oleg Melnyk, Helene Gras-Masse, Christophe Olivier, Jean-Olivier Durand, Claude Auriault, Xavier Duburco, Ahmed Bouzidi, Jean-Michel Garcia, Ouafaa El-Mahdi
  • Publication number: 20040092015
    Abstract: The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, said coupling comprising a step which consists in producing a hydrazone bond between said peptide compound and said lipophilic vector. The invention also concerns lipophilic vectors for use in said method, lipopeptides obtained by said method, uses of said lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
    Type: Application
    Filed: May 13, 2003
    Publication date: May 13, 2004
    Inventors: Dominique Bonnet, Line Bourel, Oleg Melnyk, Helene Gras-Masse
  • Publication number: 20030162185
    Abstract: The invention concerns products comprising a support whereon are fixed nucleic acids and their preparation method and use as DNA support. The invention also concerns functionalised supports, oligonucleotides and DNA's modified in position 5′ by a group selected in the group consisting of tartaric acid, serine, threonine, their derivatives and the &agr;-oxoaldehyde group, and the methods for preparing them. The invention further concerns a method for fixing a nucleic acid on a support.
    Type: Application
    Filed: October 10, 2002
    Publication date: August 28, 2003
    Inventors: Oleg Melnyk, Christophe Olivier, Nathalie Ollivier, David Hot, Ludovic Huot, Yves Lemoine, Isabelle Wolowczuk, Tam Huynh-Dinh, Catherine Gouyette, Helene Gras-Masse