Patents by Inventor Oliver Smithies

Oliver Smithies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homologous recombination for universal donor cells and chimeric mammalian hosts
    Patent number: 6514752
    Abstract: Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the &bgr;2-microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as universal donor cells. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: February 4, 2003
    Assignee: Cell Genesys, Inc.
    Inventors: Raju Kucherlapati, Beverly H. Koller, Oliver Smithies, Robert B. Dubridge, Gary Greenburg, Daniel J. Capon, Steven R. Williams, Mariona Lourdes Arbones De Rafael
  • Homologous recombination for allogeneic donor cells
    Patent number: 6139835
    Abstract: Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2- microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as allogeneic donor cells. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: October 31, 2000
    Assignee: Cell Genesys, Inc.
    Inventors: Raju Kucherlapati, Beverly H. Koller, Oliver Smithies, Robert B. Dubridge, Gary Greenburg, Daniel J. Capon, Steven R. Williams, Mariona Lourdes Arbones De Rafael
  • Mutant mice having a deficit of functional estrogen receptors
    Patent number: 5650550
    Abstract: The present invention provides a mutant non-human vertebrate, in which all or some of the germ and somatic cells contain a mutation in at least one steroid hormone receptor allele, which mutation is introduced into the vertebrate, or an ancestor of the vertebrate, at an embryonic stage, and which mutation produces a phenotype in the vertebrate characterized by a deficit of functional steroid hormone receptors encoded by the allele. Also disclosed are related methods and constructs.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenneth S. Korach, Dennis B. Lubahn, Oliver Smithies
  • Homologous recombination for universal donor cells and chimeric mammalian hosts
    Patent number: 5574205
    Abstract: Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, each of the .beta..sub.2- microglobulin gene and the IFN-.gamma.R gene is inactivated for reducing or eliminating the expression of functional MHC antigens. The resulting cells may be used as universal donor cells. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: November 12, 1996
    Assignee: Cell Genesys
    Inventors: Raju Kucherlapati, Beverly H. Koller, Oliver Smithies, Robert B. Dubridge, Gary Greenburg, Daniel J. Capon, Steven R. Williams, Mariona L. A. De Rafael
  • Homologous recombination for universal donor cells and chimeric mammalian hosts
    Patent number: 5416260
    Abstract: Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: May 16, 1995
    Assignee: University of North Carolina at Chapel Hill
    Inventors: Beverly H. Koller, Oliver Smithies
  • Homologous recombination for universal donor cells and chimeric mammalian hosts
    Patent number: 5413923
    Abstract: Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: May 9, 1995
    Assignees: Cell Genesys, Inc., Univ. of North Carolina at Chapel Hill
    Inventors: Raju Kucherlapati, Beverly H. Koller, Oliver Smithies