Patents by Inventor Oliver W. Press

Oliver W. Press has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210171651
    Abstract: The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7 and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 10, 2021
    Applicants: Fred Hutchinson Cancer Research Center, Massachusetts Institute of Technology
    Inventors: Damian J. Green, Yukang Lin, Oliver W. Press (Deceased), Alice Tzeng, Karl Dane Wittrup
  • Patent number: 8846106
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: September 30, 2014
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Publication number: 20140219950
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF WASHINGTON
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Publication number: 20130309171
    Abstract: Nanoparticle system and method for labeling, detecting, and treating biological particles. In the method, targeting functionality (fusion protein) and therapeutic/imaging modalities (nanoparticle) are separated.
    Type: Application
    Filed: April 29, 2013
    Publication date: November 21, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Oliver W. Press, Jonathan Whitney Gunn, Steven I. Park
  • Publication number: 20110288238
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: July 14, 2011
    Publication date: November 24, 2011
    Applicants: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF WASHINGTON
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 8003129
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: August 23, 2011
    Assignees: University of Washington, Univeristy of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Publication number: 20080199957
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 21, 2008
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 7374778
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: May 20, 2008
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 6835393
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: December 28, 2004
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, David Tirrell, Niren Murthy, Chantal Lackey, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter
  • Publication number: 20010007666
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: January 5, 1999
    Publication date: July 12, 2001
    Inventors: ALLAN S. HOFFMAN, PATRICK STAYTON, OLIVER W. PRESS, DAVID TIRRELL, NIREN MURTHY, CHANTAL LACKEY, LAWRENCE A. CRUM, PIERRE D. MOURAD, TYRONE M. PORTER