Patents by Inventor Olivier Lohse

Olivier Lohse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120316142
    Abstract: Compounds of formula I in salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 and A have the meanings as indicated in the specification, are useful for treating diseases mediated by the ?2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: May 4, 2012
    Publication date: December 13, 2012
    Inventors: Olivier LOHSE, St├ęphanie MONNIER, Jean-Louis REBER
  • Publication number: 20120220775
    Abstract: A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification.
    Type: Application
    Filed: May 1, 2012
    Publication date: August 30, 2012
    Inventors: Olivier Lohse, Caspar Vogel, Gerhard Penn
  • Patent number: 8198450
    Abstract: Compounds of formula I in salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 and A have the meanings as indicated in the specification, are useful for treating diseases mediated by the ?2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: June 12, 2012
    Assignee: Novartis AG
    Inventors: Olivier Lohse, Stephanie Monnier, Jean-Louis Reber
  • Publication number: 20100056481
    Abstract: The invention relates to new crystalline forms of low water soluble salts of zoledronic acid, the process for preparation of these crystalline forms, compositions containing these crystalline forms, and the use of these crystalline forms in diagnostic methods or therapeutic treatment of warm-blooded animals, especially humans. The invention relates to the crystalline form of the free acid monohydrate of zoledronic acid, the process for preparation of the crystalline form of the free acid monohydrate of zoledronic acid, compositions containing the crystalline form of the free acid monohydrate of zoledronic acid, and the use of crystalline form of the free acid monohydrate of zoledronic acid in diagnostic methods or therapeutic treatment of warm-blooded animals, especially humans.
    Type: Application
    Filed: November 26, 2007
    Publication date: March 4, 2010
    Inventors: Alexandra Glausch, Olivier Lohse, Michael Mutz, Holger Petersen, Juergen Sigg, Caspar Vogel, Hans-Joachim Weber
  • Publication number: 20100010039
    Abstract: New polymorphic crystal form of (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one maleate designated crystal form Qalpha that is useful in the treatment of inflammatory or obstructive airways diseases. A method for preparing crystal form Qalpha is also described.
    Type: Application
    Filed: August 30, 2007
    Publication date: January 14, 2010
    Inventors: Olivier Lohse, Stephanie Monnier, Guido Jordine
  • Publication number: 20090325912
    Abstract: Compounds of formula I in salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 and A have the meanings as indicated in the specification, are useful for treating diseases mediated by the ?2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: July 2, 2007
    Publication date: December 31, 2009
    Inventors: Olivier Lohse, St├ęphanie Monnier, Jean-Louis Reber
  • Patent number: 7605267
    Abstract: The invention relates to a process for preparing 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: October 20, 2009
    Assignee: Novartis AG
    Inventors: Olivier Lohse, Gerhard Penn, Hanspeter Schilling
  • Patent number: 7534890
    Abstract: A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8- hydroxy-(1H)-quinolin-2-one salt. The process involves forming an acid salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-substituted oxy-(1H)-quinolin-2-one; and converting the acid salt to a salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one without isolating the free base of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: May 19, 2009
    Assignee: Novartis AG
    Inventors: Olivier Lohse, Caspar Vogel
  • Publication number: 20090054653
    Abstract: A process for preparing 8-substituted oxy-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-ones or acceptable solvates thereof. The process involves reacting a 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-one with a reducing agent in the presence of a chiral agent and a base to form a 8-(substituted oxy)-5-((R)-2-halo-1-hydroxy-ethyl)-(1H)-quinolin-2-one, said chiral agent having a formula I or II wherein M, L, X, R1, R2 and R3 have the meanings as indicated in the specification.
    Type: Application
    Filed: June 21, 2005
    Publication date: February 26, 2009
    Inventors: Olivier Lohse, Caspar Vogel, Gerhard Penn
  • Publication number: 20060252794
    Abstract: A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one salt. The process involves forming an acid salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-substituted oxy-(1H)-quinolin-2-one; and converting the acid salt to a salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one without isolating the free base of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one.
    Type: Application
    Filed: February 27, 2004
    Publication date: November 9, 2006
    Inventors: Olivier Lohse, Caspar Vogel
  • Patent number: 7112673
    Abstract: The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: September 26, 2006
    Assignee: Novartis AG
    Inventors: Peter Funfschilling, Daniel Kaufmann, Olivier Lohse, Ulrich Beutler, Werner Zaugg
  • Publication number: 20060189653
    Abstract: The invention relates to a process for preparing 5-(?-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones.
    Type: Application
    Filed: April 1, 2004
    Publication date: August 24, 2006
    Inventors: Olivier Lohse, Gerhard Penn, Hanspeter Schilling
  • Patent number: 6933410
    Abstract: A process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine and acid addition salts thereof from 2-aminoindan. The process comprises protecting the amino group of 2-aminoindan, acetylating the ring in the protected compound, reducing the acetyl group to ethyl to form a monoethyl derivative, acetylating the monoethyl derivative, reducing the acetyl group to form a diethyl derivative, deprotecting the latter by hydrolysis and recovering the product in free or salt form. The process does not use deleterious Grignard reagents or nitrites such as isoamyl nitrite, and provides high regioselectivity and high yield of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine. In addition, the process uses acetyl halide as both a reactant and a solvent.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: August 23, 2005
    Assignee: Novartis AG
    Inventors: Mahavir Prashad, Bin Hu, Olivier Lohse
  • Publication number: 20030187301
    Abstract: A process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine and acid addition salts thereof from 2-aminoindan. The process comprises protecting the amino group of 2-aminoindan, acetylating the ring in the protected compound, reducing the acetyl group to ethyl to form a monoethyl derivative, acetylating the monoethyl derivative, reducing the acetyl group to form a diethyl derivative, deprotecting the latter by hydrolysis and recovering the product in free or salt form. The process does not use deleterious Grignard reagents or nitrites such as isoamyl nitrite, and provides high regioselectivity and high yield of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine. In addition, the process uses acetyl halide as both a reactant and a solvent.
    Type: Application
    Filed: February 14, 2003
    Publication date: October 2, 2003
    Inventors: Mahavir Prashad, Bin Hu, Olivier Lohse
  • Publication number: 20030032800
    Abstract: The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said intermediates.
    Type: Application
    Filed: August 2, 2002
    Publication date: February 13, 2003
    Inventors: Peter Fnfschilling, Daniel Kaufmann, Olivier Lohse, Ulrich Beutler, Werner Zaugg