Patents by Inventor Olli Törmäkangas

Olli Törmäkangas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Androgen receptor modulating compounds
    Patent number: 11046713
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: June 29, 2021
    Assignee: ORION CORPORATION
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10835515
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: November 17, 2020
    Assignee: ORION CORPORATION
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • ANDROGEN RECEPTOR MODULATING COMPOUNDS
    Publication number: 20200299307
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 24, 2020
    Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
  • Androgen receptor modulating compounds
    Patent number: 10711013
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: July 14, 2020
    Assignee: ORION CORPORATION
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20190321333
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 24, 2019
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10383853
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 20, 2019
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10376494
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 13, 2019
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • ANDROGEN RECEPTOR MODULATING COMPOUNDS
    Publication number: 20190100536
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: September 25, 2018
    Publication date: April 4, 2019
    Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
  • Androgen receptor modulating compounds
    Patent number: 10118933
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: November 6, 2018
    Assignee: ORION CORPORATION
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180280355
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180280354
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • Carboxamide derivative and its diastereomers in stable crystalline form
    Patent number: 10010530
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: July 3, 2018
    Assignee: Orlon Corporation
    Inventors: Olli Törmäkangas, Terhi Heikkinen
  • A CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
    Publication number: 20180008577
    Abstract: The present disclosure relates to solid crystalline forms of N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I) and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 11, 2018
    Inventors: Olli TÖRMÄKANGAS, Terhi HEIKKINEN
  • ANDROGEN RECEPTOR MODULATING COMPOUNDS
    Publication number: 20170260206
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: April 13, 2017
    Publication date: September 14, 2017
    Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, lisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
  • Androgen receptor modulating compounds
    Patent number: 9657003
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: May 23, 2017
    Assignee: ORION CORPORATION
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
  • ANDROGEN RECEPTOR MODULATING COMPOUNDS
    Publication number: 20150203479
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 23, 2015
    Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KNUUTTILA, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
  • Androgen receptor modulating compounds
    Patent number: 8975254
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 10, 2015
    Assignee: Orion Corporation
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Knuuttila, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
  • Androgen receptor modulating carboxamides
    Patent number: 8921378
    Abstract: Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14?, R15, R15?, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: December 30, 2014
    Assignee: Orion Corporation
    Inventors: Olli Törmäkangas, Gerd Wohlfahrt, Harri Salo, Rathna Durga Ramasubramanian, Pranab Kumar Patra, Arputharaj Ebenezer Martin, Terhi Heikkinen, Anniina Vesalainen, Anu Moilanen, Arja Karjalainen
  • Selective androgen receptor modulators
    Patent number: 8501814
    Abstract: A compound of formula (I), an isomer, metabolite, or a pharmaceutically acceptable salt or ester thereof is disclosed. Compounds of the invention possess utility as a tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of hypogonadism, muscle wasting, osteoporosis, benign prostate hyperplasia, obesity associated with a metabolic syndrome, male and female sexual dysfunction and reduced libido, and androgen decline in aging male or female.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: August 6, 2013
    Assignee: Orion Corporation
    Inventors: Jari Ratilainen, Olli Törmäkangas, Arja Karjalainen, Paavo Huhtala
  • ANDROGEN RECEPTOR MODULATING COMPOUNDS
    Publication number: 20120225867
    Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 27, 2010
    Publication date: September 6, 2012
    Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, lisa Höglund, Arja Karjalainen, Pia Knuuttila, Patrik Holm, Sirpa Rasku, Anniina Vesalainen