Patents by Inventor Osamu Hara

Osamu Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5602106
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R.sup.4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof are disclosed.A novel process for producing these 16-membered macrolide derivatives is also disclosed.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: February 11, 1997
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Osamu Hara, Ken-ichi Kurihara, Nobue Kikuchi, Minako Araake, Akira Shimizu, Tsuneo Okonogi, Shigeharu Inouye, Seiji Shibahara
  • Patent number: 5519122
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms;and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: May 21, 1996
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Ken-ichi Kurihara, Akira Shimizu, Shuichi Gomi, Nobue Kikuchi, Minako Araake, Tsuneo Ishizuka, Aiko Miyata, Osamu Hara, Seiji Shibahara
  • Patent number: 5489622
    Abstract: A curable silicone composition comprising an addition reaction product of an organopolysiloxane having amino groups at both ends of its molecule and a vinyl group-containing isocyanate, and a moisture-curing or anaerobic-curing catalyst and a photopolymerization catalyst.The silicone composition has high photocurability and moisture- or anaerobic-curability, easy to manufacture and easy to handle.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: February 6, 1996
    Assignee: Three Bond Co., Ltd.
    Inventors: Osamu Hara, Yasuo Hanazuka, Kunihiko Nakajima, Kohichi Naruse
  • Patent number: 5407918
    Abstract: 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: April 18, 1995
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Keiichi Ajito, Ken-ichi Kurihara, Akira Shimizu, Shuichi Gomi, Nobue Kikuchi, Minako Araake, Tsuneo Ishizuka, Aiko Miyata, Osamu Hara, Seiji Shibahara
  • Patent number: 5384340
    Abstract: A silicone composition having superior moisture- and photocurability and easy to manufacture is provided.A polyorganosiloxane having primary amino, (meth)acryl or epoxy groups at both ends is reacted with a compound having two to three hydrolyzable groups and also having (meth)acryl or epoxy group in the case where the said end groups are primary amino groups, or also having a primary amino group in the case where the said end groups are (meth)acryl or epoxy groups, then the resulting reaction product is reacted with a compound having vinyl group and (meth)acryl, epoxy or isocyanato group, to prepare a polysiloxane having hydrolyzable groups and vinyl group, and this polysiloxane is combined with a photopolymerization catalyst and a moisture-curing catalyst.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: January 24, 1995
    Assignee: Three Bond Co., Ltd.
    Inventors: Osamu Hara, Kunihiko Nakajima
  • Patent number: 5219736
    Abstract: A method of producing a 3-deacylated derivative of a 16-membered macrolide antibiotic using a microorganism belonging to the genus Phialophora or Preussia which comprises incubating said microorganism with a 16-membered macrolide antibiotic in a medium containing nutritional sources commonly used for incubating microorganisms, isolating a 3-deacylated derivative from the incubation medium, a microorganism to be used for the above method and a novel macrolide antibiotic.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: June 15, 1993
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Akira Shimizu, Shuichi Gomi, Keiichi Ajito, Takashi Yaguchi, Eriko Tanaka, Osamu Hara, Shinji Miyadoh
  • Patent number: 4854889
    Abstract: An electrical connector includes contacts to be connected to lead wires and a housing having apertures for receiving the contacts. The lead wires are connected to the contacts when the contacts are forced into the apertures of the housing. Each of the contacts comprises at one end a contact element to be in contact with an external terminal and at the other end a connection portion formed with a lead aperture through which a lead wire passes and with a slit continuous with the lead aperture. Edges of the slit pierce into an insulating coating of the lead wire and connect with a core of the lead wire under pressure.
    Type: Grant
    Filed: May 24, 1988
    Date of Patent: August 8, 1989
    Assignees: Daiichi Denshi Kogyo Kabushiki Kaisha, Iwatsu Electric Co., Ltd., Tomei Tsushin Kogyo Co., Ltd.
    Inventors: Hiroo Ohtsuka, Osamu Hara, Akira Hori, Minoru Noda
  • Patent number: 4717361
    Abstract: A contact for a connector, which includes two opposed contact elements for receiving therebetween a male contact of a mating connector. Each the contact element is provided with one or more protrusions on an opposed surface for embracing the male contact. Protrusions of the two opposed contact elements extend to that portions of the opposed contact elements which are devoid of the protrusions so as to overlap each other before the male contact is inserted between the contact elements. With this arrangement, even if the male contact is very thin, pressing force required to securely pressing the male contact by the contact elements is certainly obtained. The contact and the male contact are securely contacted without any torsional force and other forces which would otherwise be caused on these contacts.
    Type: Grant
    Filed: July 29, 1986
    Date of Patent: January 5, 1988
    Assignees: Daiichi Denshi Kogyo Kabushiki Kaisha, Iwatsu Electronic Co., Inc.
    Inventors: Yoshiaki Igarashi, Hiroo Ohtsuka, Osamu Hara
  • Patent number: 4713496
    Abstract: A coordinate input device is disclosed according to the invention, there is provided a plurality of conductors embedded in parallel on an input plane, scanning signals are supplied sequentially in such a manner of applying concurrently signals of the same phase to at least two of the conductors, then with special attention to the scanning position discriminated where the polarity of a scanning signal detected with a coordinate indicator is discriminated to have inverted, the levels of the signals before and after the inversion of their polarity are detected so as to determine where the coordinate indicator is positioned between the conductors.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: December 15, 1987
    Assignee: Alps Electric Co., Ltd.
    Inventors: Kiyoshi Kimura, Osamu Hara
  • Patent number: 4144413
    Abstract: A rotary telephone dial, in which at least one shaft is fixedly planted on a base plate. A rotary member is rotatably mounted on the shaft. Another base plate is engaged with the free end of the shaft to support the shaft. One direction assembling can be performed as a result of the above structure. A finger moving compensation mechanism is provided to obtain a sufficent allowable range of finger moving. The spring retaining structure and the governor mechanism are improved to effectively reduce the number of parts and to realize simplification of the manufacturing process.
    Type: Grant
    Filed: July 15, 1977
    Date of Patent: March 13, 1979
    Assignees: Iwasaki Tsushinki Kabushiki Kaisha, Nippon Telegraph and Telephone Public Corporation
    Inventors: Tadashi Kodama, Masayuki Murakami, Tsuneji Kimeda, Tadahiko Matsuoka, Osamu Hara, Satoru Tsukiyama