Patents by Inventor Otto Folkerts

Otto Folkerts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150141714
    Abstract: The disclosed invention provides methods and compositions for increasing terpenoid production, such as sesquiterpenoids, such as farnesene, in plant cells.
    Type: Application
    Filed: January 14, 2013
    Publication date: May 21, 2015
    Inventors: Joshua Blakeslee, Katrina Cornish, Oswald Crasta, Otto Folkerts, Dave Jessen, Ramesh Nair
  • Publication number: 20140148622
    Abstract: The present invention relates to engineering plants to express higher levels than endogenous amounts of terpenoids, such as farnesene. Plants that can be so engineered include those with large carbon stores, such as sweet sorghum and sugar cane.
    Type: Application
    Filed: November 21, 2013
    Publication date: May 29, 2014
    Applicants: THE OHIO STATE UNIVERSITY, CHROMATIN, INC.
    Inventors: Ramesh Nair, Oswald Crasta, Otto Folkerts, Joshua Blakeslee, Katrina Cornish
  • Patent number: 8686481
    Abstract: Disclosed are embodiments of a semiconductor device comprising a semiconductor body with a semiconductor image sensor comprising a two-dimensional matrix of picture elements, each picture element comprising a radiation-sensitive element coupled to MOS field effect transistors for reading the radiation-sensitive elements, wherein a semiconductor region is sunken in the surface of the body having the same conductivity type as the body and having an increased doping concentration, the semiconductor region being disposed between the radiation-sensitive elements of neighboring picture elements.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: April 1, 2014
    Assignee: Trixell
    Inventors: Joris Pieter Valentijn Maas, Willem-Jan Toren, Hein Otto Folkerts, Willem Hendrik Maes, Willem Hoekstra, Daniel Wilhelmus Elisabeth Verbugt, Daniel Hendrik Jan Maria Hermes
  • Publication number: 20080197386
    Abstract: The invention relates to a semiconductor device with a semiconductor body (12) with an image sensor comprising a two-dimensional matrix of pixels (1) each comprising a radiation-sensitive element (2) with a charge accumulating semiconductor region (2A) and coupled to a number of MOS field effect transistors (3), in which in the semiconductor body (12) an isolation region (4) is sunken for the separation of neighboring pixels (1) underneath which a further semiconductor region (5) with an enlarged doping concentration is formed. According to the invention the further semiconductor region (5) is sunken in the surface of the semiconductor body (12) and wider than the isolation region (4).
    Type: Application
    Filed: April 26, 2006
    Publication date: August 21, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Joris Pieter Valentijn Maas, Willem-Jan Toren, Hein Otto Folkerts, Willem Hendrik Maes, Willem Hoekstra, Daniel Wilhelmus Elisabeth Verbugt, Daniel Hendrik Jan Maria Hermes
  • Patent number: 7241934
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: July 10, 2007
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
  • Publication number: 20060162009
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 20, 2006
    Applicants: Pioneer Hi-Bred International, Inc., Curagen Corporation
    Inventors: Jonathan Duvick, Jacob Gilliam, Joyce Maddox, Aragula Rao, Oswald Crasta, Otto Folkerts
  • Patent number: 6987212
    Abstract: The present invention provides transformed plants comprising a polynucleotide enconding amino polyol amine oxidase (APAO ) from Exophiala spinifera and a method of expressing APAO transgenic plants and seeds. In this way, transgenic plant can be produced having fumonisin degrading capability, as well as with the capability of producing the degrading enzymes.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: January 17, 2006
    Assignees: Pioneer Hi-Bred International, Inc., Curagen Corporation
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
  • Patent number: 6943279
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella airovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: September 13, 2005
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
  • Patent number: 6835569
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 28, 2004
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald Crasta, Otto Folkerts
  • Patent number: 6822140
    Abstract: Compositions and methods for the complete detoxification of fumonisin and fumonisin degradation products are provided. Particularly, nucleotide sequences corresponding to the detoxification enzymes are provided. The sequences find use in preparing expression cassettes for the transformation of a broad variety of host cells and organisms.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: November 23, 2004
    Assignees: Pioneer Hi-Bred International, Inc., CuraGen Corporation
    Inventors: Jon Duvick, Joyce Maddox, Jacob Gilliam, Otto Folkerts, Oswald R. Crasta
  • Patent number: 6791013
    Abstract: The maize myo-inositol-1-phosphate synthase (MIP synthase) promoter is a novel embryo specific regulatory sequence useful in expressing heterologous nucleic acids in plants.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: September 14, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Katherine Armstrong, Timothy D. Hey, Otto Folkerts, Kelley A. Smith, Nicole L. Hopkins
  • Publication number: 20040168212
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.
    Type: Application
    Filed: July 22, 2003
    Publication date: August 26, 2004
    Applicants: Pioneer Hi-Bred International, Inc., CuraGen Corp.
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
  • Patent number: 6767742
    Abstract: Monoclonal antibodies expressed in plant cells bind targeted transit peptides to decrease steady state levels of passenger proteins in plant organelles.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: July 27, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Kitisri Sukhapinda, James M. Hasler, James K. Petell, James A. Strickland, Otto Folkerts
  • Publication number: 20040143868
    Abstract: Regulatory seqeunces derived from the maize per5 gene have utility in plant biotechnology.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 22, 2004
    Inventors: Michael Ainley, Katherine Armstrong, Scott Belmar, Otto Folkerts, Nicole Hopkins, Michael A. Menke, Dayakar Pareddy, Joseph F. Petolino, Kelley Smith, Aaron Woosley
  • Patent number: 6699984
    Abstract: Regulatory sequences derived from the maize per5 gene have utility in plant biotechnology.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: March 2, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Michael Ainley, Katherine Armstrong, Scott Belmar, Otto Folkerts, Nicole Hopkins, Michael A. Menke, Dayakar Pareddy, Joseph F. Petolino, Kelley Smith, Aaron Woosley
  • Publication number: 20040006787
    Abstract: Compositions and methods of use for the expression of plant pathogen defense-related and signaling genes are provided. The compositions include nucleotide sequences identified from tomato that show specific patterns of gene expression associated with the Avr-Pto mediated defense response in tomato plants resistant to bacterial speck disease caused by Pseudomonas syringae pathovar tomato [strain T1(A)]. The nucleotide sequences are specific to genes that are up-regulated or down-regulated in response to the interaction of AvrPto and Pto in the presence of Prf. These compositions have agricultural utility for increasing resistance to a variety of biotic and abiotic stresses, including plant pathogens.
    Type: Application
    Filed: January 14, 2003
    Publication date: January 8, 2004
    Inventors: Gregory B. Martin, Kiran Kumar Mysore, Oswald R. Crasta, Otto Folkerts, Peter Swirsky
  • Publication number: 20030126636
    Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.
    Type: Application
    Filed: January 26, 2001
    Publication date: July 3, 2003
    Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
  • Patent number: 6534291
    Abstract: Compositions and methods for the complete detoxification of fumonisin and fumonisin degradation products are provided. Particularly, nucleotide sequences corresponding to the detoxification enzymes are provided. The sequences find use in preparing expression cassettes for the transformation of a broad variety of host cells and organisms.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: March 18, 2003
    Assignees: Pioneer Hi-Bred International, Inc., CuraGen Corporation
    Inventors: Jon Duvick, Joyce Maddox, Jacob Gilliam, Otto Folkerts, Oswald R. Crasta
  • Patent number: 6515202
    Abstract: The invention relates to the genetic manipulation of plants, particularly to the expression of genes involved in oxylipin metabolism in plants. Nucleotide sequences encoding homologues of Old Yellow Enzyme, and inducible promoters and proteins thereof, are provided. The sequences find use in modifying oxylipin metabolism in plants, increasing the resistance of plants to stress, regulating gene expression in plants, and in the production of oxylipins in plants.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: February 4, 2003
    Assignees: Pioneer Hi-Bred International, Inc., CuraGen Corporation
    Inventors: Virginia C. Crane, Jon Duvick, Yogesh K. Sharma, Oswald R. Crasta, Otto Folkerts
  • Publication number: 20030014775
    Abstract: An enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of an gene in a plant. A transgenic plant comprising nucleic acids encoding for an enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in said plant.
    Type: Application
    Filed: September 21, 2001
    Publication date: January 16, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Michael G. Zwick, Brent V. Edington, James A. McSwiggen, Patricia Ann Owens Merlo, Lining Guo, Thomas A. Skokut, Scott A. Young, Otto Folkerts, Donald J. Merlo