Patents by Inventor Otto Folkerts
Otto Folkerts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150141714Abstract: The disclosed invention provides methods and compositions for increasing terpenoid production, such as sesquiterpenoids, such as farnesene, in plant cells.Type: ApplicationFiled: January 14, 2013Publication date: May 21, 2015Inventors: Joshua Blakeslee, Katrina Cornish, Oswald Crasta, Otto Folkerts, Dave Jessen, Ramesh Nair
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Publication number: 20140148622Abstract: The present invention relates to engineering plants to express higher levels than endogenous amounts of terpenoids, such as farnesene. Plants that can be so engineered include those with large carbon stores, such as sweet sorghum and sugar cane.Type: ApplicationFiled: November 21, 2013Publication date: May 29, 2014Applicants: THE OHIO STATE UNIVERSITY, CHROMATIN, INC.Inventors: Ramesh Nair, Oswald Crasta, Otto Folkerts, Joshua Blakeslee, Katrina Cornish
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Patent number: 8686481Abstract: Disclosed are embodiments of a semiconductor device comprising a semiconductor body with a semiconductor image sensor comprising a two-dimensional matrix of picture elements, each picture element comprising a radiation-sensitive element coupled to MOS field effect transistors for reading the radiation-sensitive elements, wherein a semiconductor region is sunken in the surface of the body having the same conductivity type as the body and having an increased doping concentration, the semiconductor region being disposed between the radiation-sensitive elements of neighboring picture elements.Type: GrantFiled: April 26, 2006Date of Patent: April 1, 2014Assignee: TrixellInventors: Joris Pieter Valentijn Maas, Willem-Jan Toren, Hein Otto Folkerts, Willem Hendrik Maes, Willem Hoekstra, Daniel Wilhelmus Elisabeth Verbugt, Daniel Hendrik Jan Maria Hermes
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Publication number: 20080197386Abstract: The invention relates to a semiconductor device with a semiconductor body (12) with an image sensor comprising a two-dimensional matrix of pixels (1) each comprising a radiation-sensitive element (2) with a charge accumulating semiconductor region (2A) and coupled to a number of MOS field effect transistors (3), in which in the semiconductor body (12) an isolation region (4) is sunken for the separation of neighboring pixels (1) underneath which a further semiconductor region (5) with an enlarged doping concentration is formed. According to the invention the further semiconductor region (5) is sunken in the surface of the semiconductor body (12) and wider than the isolation region (4).Type: ApplicationFiled: April 26, 2006Publication date: August 21, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Joris Pieter Valentijn Maas, Willem-Jan Toren, Hein Otto Folkerts, Willem Hendrik Maes, Willem Hoekstra, Daniel Wilhelmus Elisabeth Verbugt, Daniel Hendrik Jan Maria Hermes
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Patent number: 7241934Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.Type: GrantFiled: December 22, 2003Date of Patent: July 10, 2007Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
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Publication number: 20060162009Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella atrovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.Type: ApplicationFiled: December 22, 2003Publication date: July 20, 2006Applicants: Pioneer Hi-Bred International, Inc., Curagen CorporationInventors: Jonathan Duvick, Jacob Gilliam, Joyce Maddox, Aragula Rao, Oswald Crasta, Otto Folkerts
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Patent number: 6987212Abstract: The present invention provides transformed plants comprising a polynucleotide enconding amino polyol amine oxidase (APAO ) from Exophiala spinifera and a method of expressing APAO transgenic plants and seeds. In this way, transgenic plant can be produced having fumonisin degrading capability, as well as with the capability of producing the degrading enzymes.Type: GrantFiled: July 22, 2003Date of Patent: January 17, 2006Assignees: Pioneer Hi-Bred International, Inc., Curagen CorporationInventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6943279Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera and Rhinocladiella airovirens. The polynucleotides may be mutated to remove glycosylation sites and cysteine residues. Additionally, the present invention provides recombinant expression cassettes, host cells, transgenic plants, and transgenic seed. The present invention also provides for polynucleotides containing both APAO and a fumonisin esterase. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and eukaryotic systems, methods for detecting fumonisins, and methods for identifying transformed plant cells. Methods for degrading fungal toxins in plants, grain, grain processing, silage, food crops and in animal feed are also disclosed.Type: GrantFiled: September 8, 2000Date of Patent: September 13, 2005Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Aragula Gururaj Rao, Oswald R. Crasta, Otto Folkerts
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Patent number: 6835569Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems.Type: GrantFiled: January 26, 2001Date of Patent: December 28, 2004Assignee: Pioneer Hi-Bred International, Inc.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald Crasta, Otto Folkerts
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Patent number: 6822140Abstract: Compositions and methods for the complete detoxification of fumonisin and fumonisin degradation products are provided. Particularly, nucleotide sequences corresponding to the detoxification enzymes are provided. The sequences find use in preparing expression cassettes for the transformation of a broad variety of host cells and organisms.Type: GrantFiled: June 15, 2001Date of Patent: November 23, 2004Assignees: Pioneer Hi-Bred International, Inc., CuraGen CorporationInventors: Jon Duvick, Joyce Maddox, Jacob Gilliam, Otto Folkerts, Oswald R. Crasta
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Patent number: 6791013Abstract: The maize myo-inositol-1-phosphate synthase (MIP synthase) promoter is a novel embryo specific regulatory sequence useful in expressing heterologous nucleic acids in plants.Type: GrantFiled: December 1, 2000Date of Patent: September 14, 2004Assignee: Dow AgroSciences LLCInventors: Katherine Armstrong, Timothy D. Hey, Otto Folkerts, Kelley A. Smith, Nicole L. Hopkins
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Publication number: 20040168212Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: ApplicationFiled: July 22, 2003Publication date: August 26, 2004Applicants: Pioneer Hi-Bred International, Inc., CuraGen Corp.Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6767742Abstract: Monoclonal antibodies expressed in plant cells bind targeted transit peptides to decrease steady state levels of passenger proteins in plant organelles.Type: GrantFiled: July 21, 1999Date of Patent: July 27, 2004Assignee: Dow AgroSciences LLCInventors: Kitisri Sukhapinda, James M. Hasler, James K. Petell, James A. Strickland, Otto Folkerts
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Publication number: 20040143868Abstract: Regulatory seqeunces derived from the maize per5 gene have utility in plant biotechnology.Type: ApplicationFiled: January 16, 2004Publication date: July 22, 2004Inventors: Michael Ainley, Katherine Armstrong, Scott Belmar, Otto Folkerts, Nicole Hopkins, Michael A. Menke, Dayakar Pareddy, Joseph F. Petolino, Kelley Smith, Aaron Woosley
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Patent number: 6699984Abstract: Regulatory sequences derived from the maize per5 gene have utility in plant biotechnology.Type: GrantFiled: August 22, 2000Date of Patent: March 2, 2004Assignee: Dow AgroSciences LLCInventors: Michael Ainley, Katherine Armstrong, Scott Belmar, Otto Folkerts, Nicole Hopkins, Michael A. Menke, Dayakar Pareddy, Joseph F. Petolino, Kelley Smith, Aaron Woosley
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Publication number: 20040006787Abstract: Compositions and methods of use for the expression of plant pathogen defense-related and signaling genes are provided. The compositions include nucleotide sequences identified from tomato that show specific patterns of gene expression associated with the Avr-Pto mediated defense response in tomato plants resistant to bacterial speck disease caused by Pseudomonas syringae pathovar tomato [strain T1(A)]. The nucleotide sequences are specific to genes that are up-regulated or down-regulated in response to the interaction of AvrPto and Pto in the presence of Prf. These compositions have agricultural utility for increasing resistance to a variety of biotic and abiotic stresses, including plant pathogens.Type: ApplicationFiled: January 14, 2003Publication date: January 8, 2004Inventors: Gregory B. Martin, Kiran Kumar Mysore, Oswald R. Crasta, Otto Folkerts, Peter Swirsky
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Publication number: 20030126636Abstract: The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.Type: ApplicationFiled: January 26, 2001Publication date: July 3, 2003Inventors: Jonathan P. Duvick, Jacob T. Gilliam, Joyce R. Maddox, Oswald R. Crasta, Otto Folkerts
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Patent number: 6534291Abstract: Compositions and methods for the complete detoxification of fumonisin and fumonisin degradation products are provided. Particularly, nucleotide sequences corresponding to the detoxification enzymes are provided. The sequences find use in preparing expression cassettes for the transformation of a broad variety of host cells and organisms.Type: GrantFiled: October 2, 2000Date of Patent: March 18, 2003Assignees: Pioneer Hi-Bred International, Inc., CuraGen CorporationInventors: Jon Duvick, Joyce Maddox, Jacob Gilliam, Otto Folkerts, Oswald R. Crasta
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Patent number: 6515202Abstract: The invention relates to the genetic manipulation of plants, particularly to the expression of genes involved in oxylipin metabolism in plants. Nucleotide sequences encoding homologues of Old Yellow Enzyme, and inducible promoters and proteins thereof, are provided. The sequences find use in modifying oxylipin metabolism in plants, increasing the resistance of plants to stress, regulating gene expression in plants, and in the production of oxylipins in plants.Type: GrantFiled: May 18, 2000Date of Patent: February 4, 2003Assignees: Pioneer Hi-Bred International, Inc., CuraGen CorporationInventors: Virginia C. Crane, Jon Duvick, Yogesh K. Sharma, Oswald R. Crasta, Otto Folkerts
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Publication number: 20030014775Abstract: An enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of an gene in a plant. A transgenic plant comprising nucleic acids encoding for an enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in said plant.Type: ApplicationFiled: September 21, 2001Publication date: January 16, 2003Applicant: Ribozyme Pharmaceuticals, Inc.Inventors: Michael G. Zwick, Brent V. Edington, James A. McSwiggen, Patricia Ann Owens Merlo, Lining Guo, Thomas A. Skokut, Scott A. Young, Otto Folkerts, Donald J. Merlo