Patents by Inventor Otto Martin LEHMANN

Otto Martin LEHMANN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimization of C-8 sterol isomerization
    Patent number: 12049617
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: July 30, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • Optimization of C-5 sterol desaturation
    Patent number: 12018309
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: June 25, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Christopher Mark Farrell, Lisa Ann Laprade, Otto Martin Lehmann, Joshua Trueheart, Bastien Jean Wolfgang Chevreux
  • METHODS AND KITS FOR MEASURING PROTEASE ACTIVITY IN FEED
    Publication number: 20240200120
    Abstract: The present invention provides a method and a kit for measuring protease activity in a feed sample. The method and the kit avoids the influence of feed inhibitors present in a feed sample and thus provides a stable and accurate method for measuring protease activity in the feed sample with high sensitivity.
    Type: Application
    Filed: March 3, 2021
    Publication date: June 20, 2024
    Inventors: Claire Véronique CHATELLE, Otto Martin LEHMANN
  • OPTIMIZATION OF C-8 STEROL ISOMERIZATION
    Publication number: 20210238539
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.
    Type: Application
    Filed: May 21, 2019
    Publication date: August 5, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART, Bastien Jean Wolfgang CHEVREUX
  • OPTIMIZATION OF C-5 STEROL DESATURATION
    Publication number: 20210222222
    Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Application
    Filed: May 21, 2019
    Publication date: July 22, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART, Bastien Jean Wolfgang CHEVREUX
  • MODIFIED STEROL ACYLTRANSFERASES
    Publication number: 20210115412
    Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 22, 2021
    Inventors: Christopher Mark FARRELL, Lisa Ann LAPRADE, Otto Martin LEHMANN, Joshua TRUEHEART
  • MODIFIED STEROL ACYLTRANSFERASES
    Publication number: 20210095325
    Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a host strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 1, 2021
    Inventors: Otto Martin LEHMANN, Harald PICHLER, Holly STOLTERFOHT