Patents by Inventor Pamela Gehron Robey

Pamela Gehron Robey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170258847
    Abstract: The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 14, 2017
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Songtao Shi, Pamela Gehron Robey, Stan Gronthos, Masako Miura
  • Patent number: 9682107
    Abstract: The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 20, 2017
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Songtao Shi, Pamela Gehron Robey, Stan Gronthos, Masako Miura
  • Publication number: 20170021149
    Abstract: A biological sampling platform includes a substrate and a first through hole disposed in the substrate to receive a first sample and to provide the first sample to a biological system in response to the biological sampling platform being disposed in the biological system, the substrate being cleavable to provide a discrete layer having a thickness effective for analysis of the discreet layer by transmission microscopy. A process for collecting a biological sample includes disposing a first through hole in a substrate; disposing a first sample in the first through hole to form a biological sampling platform; disposing the biological sampling platform in a biological system; providing the first sample to the biological system in response to the biological sampling platform being disposed in the biological system; and receiving a first biological sample from the biological system in the first through hole to collect the first biological sample.
    Type: Application
    Filed: April 14, 2015
    Publication date: January 26, 2017
    Inventors: Carl G. Simon, JR., Subhadip Bodhak, Luia A. Fernandez de Castro Diaz, Pamela Gehron Robey
  • Publication number: 20160303357
    Abstract: A biological sampling platform includes a substrate and a first through hole disposed in the substrate to receive a first sample and to provide the first sample to a biological system in response to the biological sampling platform being disposed in the biological system, the substrate being cleavable to provide a discrete layer having a thickness effective for analysis of the discreet layer by transmission microscopy. A process for collecting a biological sample includes disposing a first through hole in a substrate; disposing a first sample in the first through hole to form a biological sampling platform; disposing the biological sampling platform in a biological system; providing the first sample to the biological system in response to the biological sampling platform being disposed in the biological system; and receiving a first biological sample from the biological system in the first through hole to collect the first biological sample.
    Type: Application
    Filed: April 14, 2015
    Publication date: October 20, 2016
    Inventors: Carl G. Simon, JR., Subhadip Bodhak, Luia A. Fernandez de Castro Diaz, Pamela Gehron Robey
  • Publication number: 20160008404
    Abstract: The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
    Type: Application
    Filed: September 29, 2015
    Publication date: January 14, 2016
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Songtao Shi, Pamela Gehron Robey, Stan Gronthos, Masako Miura
  • Patent number: 9175264
    Abstract: The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
    Type: Grant
    Filed: April 19, 2003
    Date of Patent: November 3, 2015
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Songtao Shi, Pamela Gehron Robey, Stan Gronthos, Masako Miura
  • Patent number: 8921340
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: December 30, 2014
    Assignees: Trustees of Dartmouth College, Rutgers, The State University of New Jersey, The United States of America, as represented by the Secretary Department of Health and Human Services
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
  • Publication number: 20140377235
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
  • Publication number: 20140328809
    Abstract: The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Gordon W. Gribble, Damian Medici, Pamela Gehron Robey, Karen T. Liby, Michael B. Sporn, Nanjoo Suh
  • Patent number: 7052907
    Abstract: The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: May 30, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Songtao Shi, Stan Gronthos, Pamela Gehron Robey
  • Publication number: 20040058442
    Abstract: The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.
    Type: Application
    Filed: September 22, 2003
    Publication date: March 25, 2004
    Inventors: Songtao Shi, Stan Gronthos, Pamela Gehron Robey
  • Patent number: 5914121
    Abstract: An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without fibrin glue and implanted into a mammal. This protocol results in the formation of self-maintained human bone which supports hematopoiesis. This model system can be used to screen compounds which inhibit or stimulate bone formation. The marrow stromal fibroblast delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: June 22, 1999
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Pamela Gehron Robey, Paolo Bianco, Sergei Kuznetsov, David Rowe, Paul Krebsbach, Mahesh H. Mankani