Patents by Inventor Pamela Peralta-Yahya

Pamela Peralta-Yahya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
    Publication number: 20220090154
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same.
    Type: Application
    Filed: July 21, 2021
    Publication date: March 24, 2022
    Inventors: Pamela PERALTA-YAHYA, Amy M. EHRENWORTH
  • Engineered thioesterase mutants and methods of using same to produce fatty acids
    Patent number: 11279937
    Abstract: The disclosure is directed to a method of engineering a heterologous thioesterase (TE) enzyme to interact with endogenous acyl-ACP proteins in order to produce molecules of interest in a bacterial host. The method can identify amino acids at the binding interface between the heterologous TE and the endogenous acyl-ACP that can be substituted so that the heterologous TE can better interact with the endogenous acyl-ACP. Mutant heterologous TE enzymes with improved interactions with the endogenous acyl-ACP are also provided.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: March 22, 2022
    Assignee: Georgia Tech Research Corporation
    Inventors: Pamela Peralta-Yahya, Stephen Sarria, Adam Verga, Michael D. Burkart
  • Pterin-dependent biocatalysts and uses thereof
    Patent number: 11085060
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: August 10, 2021
    Assignee: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Pamela Peralta-Yahya, Amy M. Ehrenworth
  • G-protein coupled receptor (GPCR)-based biosensors and uses thereof
    Patent number: 10683559
    Abstract: Provided herein are GPCR-based chemical biosensors that can have a sensing unit, a processing unit, and a response unit that can be used to detect a chemical of interest. Also provided herein are methods of making and using the GPCR-based chemical biosensors.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 16, 2020
    Assignee: Georgia Tech Research Corporation
    Inventors: Pamela Peralta-Yahya, Kuntal Mukherjee, Souryadeep Bhattacharyya, Stephen Sarria
  • THIOESTERASE MUTANTS AND METHODS OF USING SAME
    Publication number: 20200115714
    Abstract: The disclosure is directed to a method of engineering a heterologous thioesterase (TE) enzyme to interact with endogenous acyl-ACP proteins in order to produce molecules of interest in a bacterial host. The method can identify amino acids at the binding interface between the heterologous TE and the endogenous acyl-ACP that can be substituted so that the heterologous TE can better interact with the endogenous acyl-ACP. Mutant heterologous TE enzymes with improved interactions with the endogenous acyl-ACP are also provided.
    Type: Application
    Filed: October 10, 2019
    Publication date: April 16, 2020
    Inventors: Pamela Peralta-Yahya, Stephen Sarria, Adam Verga
  • G-PROTEIN COUPLED RECEPTOR (GPCR)-BASED BIOSENSORS AND USES THEREOF
    Publication number: 20180187272
    Abstract: Provided herein are GPCR-based chemical biosensors that can have a sensing unit, a processing unit, and a response unit that can be used to detect a chemical of interest. Also provided herein are methods of making and using the GPCR-based chemical biosensors.
    Type: Application
    Filed: November 6, 2017
    Publication date: July 5, 2018
    Inventors: Pamela Peralta-Yahya, Kuntal Mukherjee, Souryadeep Bhattacharyya, Stephen Sarria
  • PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
    Publication number: 20170362617
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 21, 2017
    Inventors: PAMELA PERALTA-YAHYA, AMY M. EHRENWORTH
  • G-protein coupled receptor (GPCR)-based biosensors and uses thereof
    Patent number: 9809862
    Abstract: Provided herein are GPCR-based chemical biosensors that can have a sensing unit, a processing unit, and a response unit that can be used to detect a chemical of interest. Also provided herein are methods of making and using the GPCR-based chemical biosensors.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: November 7, 2017
    Assignee: Georgia Tech Research Corporation
    Inventors: Pamela Peralta-Yahya, Kuntal Mukherjee, Souryadeep Bhattacharyya, Stephen Sarria
  • G-PROTEIN COUPLED RECEPTOR (GPCR)-BASED BIOSENSORS AND USES THEREOF
    Publication number: 20160122832
    Abstract: Provided herein are GPCR-based chemical biosensors that can have a sensing unit, a processing unit, and a response unit that can be used to detect a chemical of interest. Also provided herein are methods of making and using the GPCR-based chemical biosensors.
    Type: Application
    Filed: August 11, 2015
    Publication date: May 5, 2016
    Inventors: Pamela Peralta-Yahya, Kuntal Mukherjee, Souryadeep Bhattacharyya, Stephen Sarria
  • Isoprenoid based alternative diesel fuel
    Patent number: 9109175
    Abstract: Fuel compositions are provided comprising a hydrogenation product of a monocyclic sesquiterpene (e.g., hydrogenated bisabolene) and a fuel additive. Methods of making and using the fuel compositions are also disclosed.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: August 18, 2015
    Assignee: The Regents of the University of California
    Inventors: Taek Soon Lee, Pamela Peralta-Yahya, Jay D. Keasling
  • ISOPRENOID BASED ALTERNATIVE DIESEL FUEL
    Publication number: 20130298861
    Abstract: Fuel compositions are provided comprising a hydrogenation product of a monocyclic sesquiterpene (e.g., hydrogenated bisabolene) and a fuel additive. Methods of making and using the fuel compositions are also disclosed.
    Type: Application
    Filed: November 8, 2011
    Publication date: November 14, 2013
    Applicant: The Regents of the University of California
    Inventors: Taek Soon Lee, Pamela Peralta-Yahya, Jay D. Keasling