Patents by Inventor Paolo BRANDI

Paolo BRANDI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lyophilized formulations of bendamustine hydrochloride
    Patent number: 9308174
    Abstract: New formulations of bendamustine hydrochloride having HPLC purity higher than 99% obtained through the lyophilization of aqueous solutions without organic solvents, are described.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: April 12, 2016
    Assignee: CHEMI S.P.A.
    Inventors: Stefano Turchetta, Maurizio Zenoni, Paolo Brandi
  • Process for the synthesis of azacitidine and decitabine
    Patent number: 9266863
    Abstract: Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: February 23, 2016
    Assignee: CHEMI SPA
    Inventors: Lorenzo De Ferra, Maurizio Zenoni, Stefano Turchetta, Mauro Anibaldi, Ettore Ammirati, Paolo Brandi, Giorgio Berardi
  • Bortezomib esters and formulations thereof
    Patent number: 9206229
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: December 8, 2015
    Assignee: CHEMI S.P.A.
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • Bortezomib Esters And Formulations Thereof
    Publication number: 20150232508
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Application
    Filed: August 1, 2013
    Publication date: August 20, 2015
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • Process for the synthesis of pemetrexed disodium salt
    Patent number: 8981090
    Abstract: The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 17, 2015
    Assignee: Chemi S.p.A.
    Inventors: Umberto Ciambecchini, Stefano Turchetta, Maurizio Zenoni, Lorenzo De Ferra, Paolo Brandi
  • LYOPHILIZED FORMULATIONS OF BENDAMUSTINE HYDROCHLORIDE
    Publication number: 20140378518
    Abstract: New formulations of bendamustine hydrochloride having HPLC purity higher than 99% obtained through the lyophilization of aqueous solutions without organic solvents, are described.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 25, 2014
    Inventors: Stefano Turchetta, Maurizio Zenoni, Paolo Brandi
  • NOVEL PROCESS FOR THE SYNTHESIS OF PEMETREXED DISODIUM SALT
    Publication number: 20120172595
    Abstract: The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.
    Type: Application
    Filed: July 5, 2011
    Publication date: July 5, 2012
    Applicant: CHEMI S.P.A.
    Inventors: Umberto CIAMBECCHINI, Stefano TURCHETTA, Maurizio ZENONI, Lorenzo DE FERRA, Paolo BRANDI
  • PROCESS FOR THE SYNTHESIS OF AZACITIDINE AND DECITABINE
    Publication number: 20110245485
    Abstract: Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.
    Type: Application
    Filed: March 28, 2011
    Publication date: October 6, 2011
    Applicant: CHEMI SPA
    Inventors: Lorenzo DE FERRA, Maurizio ZENONI, Stefano TURCHETTA, Mauro ANIBALDI, Ettore AMMIRATI, Paolo BRANDI, Giorgio BERARDI