Patents by Inventor Paolo Tosatti

Paolo Tosatti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING BTK INHIBITORS
    Publication number: 20240132508
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.
    Type: Application
    Filed: November 3, 2023
    Publication date: April 25, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan BACHMANN, Lukas CHYTIL, Serena Maria FANTASIA, Alec FETTES, Ursula HOFFMANN, Christian Oliver KAPPE, Rene LEBL, Kurt PUENTENER, Paolo TOSATTI, Jason Douglas WILLIAMS
  • Process for the Preparation of a Chiral Piperazine-2-carboxylic Acid
    Publication number: 20230175026
    Abstract: The invention relates to a novel process for the preparation of a chiral piperazine-2- carboxylic acid or of a salt thereof of the formula (I). The chiral piperazine-2-carboxylic acid derivatives of the formula (I) are key intermediates for the preparation of fused heteroaryl dihydro pyrimidines which are useful for the treatment and prophylaxis of hepatitis B virus infections.
    Type: Application
    Filed: April 26, 2021
    Publication date: June 8, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joséphine Eliette Françoise CINQUALBRE, Stefan HILDBRAND, Paolo TOSATTI, Kurt PUENTENER, Dennis WETZL, Hans IDING, Patrick STOCKER, Nicolas Mickael FÉDOU, Paul SPURR
  • Heteroaryl-1,2,4-triazole and heteroaryl-tetrazole compounds for controlling ectoparasites
    Patent number: 10981897
    Abstract: The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy)2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 20, 2021
    Assignee: Elanco Tiergesundheit AG
    Inventors: Paolo Tosatti, Jean-Yves Wach
  • HETEROARYL-1,2,4-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS FOR CONTROLLING ECTOPARASITES
    Publication number: 20190256501
    Abstract: The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy) 2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 22, 2019
    Inventors: Paolo Tosatti, Jean-Yves Wach
  • Heteroaryl-1,2,4-triazole and heteroaryl-tetrazole compounds for controlling ectoparasites
    Patent number: 10287276
    Abstract: The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy)2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 14, 2019
    Assignee: Elanco Tiergesundheit AG
    Inventors: Paolo Tosatti, Jean-Yves Wach
  • HETEROARYL-1,2,4-TRIAZOLE AND HETEROARYL-TETRAZOLE COMPOUNDS FOR CONTROLLING ECTOPARASITES
    Publication number: 20180186778
    Abstract: The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy)2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.
    Type: Application
    Filed: April 28, 2017
    Publication date: July 5, 2018
    Inventors: Paolo Tosatti, Jean-Yves Wach