Patents by Inventor Paolo Ventura

Paolo Ventura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160045434
    Abstract: The present invention relates to inhalation formulations of drugs in the form of dry powder for inhalation administration deliverable as such with an inhaler and provided with high deliverability, respirability and stability. In particular, the invention relates to a pharmaceutical composition for inhalation in the form of powder comprising at least a first and a second powder, in which at least said first powder contains an active agent in an amount greater than 1% by weight with respect to the weight of said first powder. Both the powders comprise leucine in an amount ranging from 5 to 70% by weight with respect to the weight of each powder and a sugar in an amount ranging from 20 to 90% by weight with respect to the weight of each powder. The composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 80.
    Type: Application
    Filed: April 9, 2014
    Publication date: February 18, 2016
    Applicant: ERATECH S.R.L.
    Inventors: Giovanni Caponetti, Loretta Maggi, Cristina Veneziani, Paolo Ventura, Laura Zanellotti
  • Patent number: 8420058
    Abstract: Compositions which contain an active ingredient, a propellant containing a hydrofluoroalkane (HFA), a co-solvent, and a low-volatility component are useful for administering the active ingredient via an aerosol.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: April 16, 2013
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, Davis Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Patent number: 8142763
    Abstract: The invention relates to pressurized metered dose inhalers (MDIs) in which all or part of the internal surface is stainless steel, anodized aluminum, or lined with an inert organic coating and which contain a formulation which comprises ipratropium bromide.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: March 27, 2012
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20110100361
    Abstract: The invention relates to pressurized metered dose inhalers (MDIs) in which all or part of the internal surface is lined with an inert organic coating and which contain a formulation which comprises TA 2005.
    Type: Application
    Filed: January 11, 2011
    Publication date: May 5, 2011
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: David LEWIS, David GANDERTON, Brian MEAKIN, Paolo VENTURA, Gaetano BRAMBILLA, Raffaella GARZIA
  • Patent number: 7740463
    Abstract: The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: June 22, 2010
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20100047184
    Abstract: A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, comprising an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermohygrometric conditions and with standard tabletting equipment. A pre-granulation process is also disclosed.
    Type: Application
    Filed: October 26, 2009
    Publication date: February 25, 2010
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Paolo Chiesi, Paolo Ventura, Rosa Mezzadri, Gaetano Brambilla, Daniela Acerbi
  • Publication number: 20090311196
    Abstract: Compositions which contain an active ingredient, a propellant containing a hydrofluoroalkane (HFA), a co-solvent, and a low-volatility component are useful for administering the active ingredient via an aerosol.
    Type: Application
    Filed: August 26, 2009
    Publication date: December 17, 2009
    Applicant: Chiesi Farmaceutici S.p.A
    Inventors: David LEWIS, Davis GANDERTON, Brian MEAKIN, Paolo VENTURA, Gaetano BRAMBILLA, Raffaella GARZIA
  • Patent number: 7625865
    Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: December 1, 2009
    Assignee: Universita Degli Studi Di Parma
    Inventors: Paolo Colombo, Stefano Cagnani, Paolo Ventura
  • Patent number: 7601336
    Abstract: A composition for use in an aerosol inhaler, the composition comprising an active material, a propellant containing a hydrofluoroalkane (HFA), a cosolvent and further comprising a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler, filling of an aerosol container and use of the composition for the administration of active materials by inhalation.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: October 13, 2009
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, Davis Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20080247965
    Abstract: The invention relates to pressurized metered dose inhalers (MDIs) in which all or part of the internal surface is lined with an inert organic coating and which contain a formulation which comprises TA 2005.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 9, 2008
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: David LEWIS, David GANDERTON, Brian MEAKIN, Paolo VENTURA, Gaetano BRAMBILLA, Raffaella GARZIA
  • Patent number: 7399528
    Abstract: Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: July 15, 2008
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Giovanni Caponetti, Pier Luigi Catellani, Ruggero Bettini, Paolo Colombo, Paolo Ventura
  • Publication number: 20080115782
    Abstract: The invention relates to pressurized metered dose inhalers (MDIs) in which all or part of the internal surface is stainless steel, anodized aluminum, or lined with an inert organic coating and which contain a formulation which comprises ipratropium bromide.
    Type: Application
    Filed: January 31, 2008
    Publication date: May 22, 2008
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: David LEWIS, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Patent number: 7347199
    Abstract: The invention relates to the use of pressurized metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminum or lined with an inert organic coating; and to compositions to be delivered with said MDIs.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: March 25, 2008
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20070154404
    Abstract: The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
    Type: Application
    Filed: March 26, 2004
    Publication date: July 5, 2007
    Inventors: Paolo Colombo, Stefano Cagnani, Paolo Ventura
  • Patent number: 7223381
    Abstract: The invention relates to the use of pressurized metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodized aluminum or lined with an inert organic coating; and to compositions to be delivered with said MDIs.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: May 29, 2007
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20060257330
    Abstract: Powdery pharmaceutical compositions including an active ingredient and carrier particles containing only a small amount of lubricant, 0.05-0.5% by weight, are used to prepare dry powder inhalers in order to increase the fine particle dose. A process for coating the surface of the carrier particles with such little amount of lubricant is also provided. Use of limited amount of lubricant is safe and provides ordered stable mixtures without segregation of the active particles during handling and before use.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 16, 2006
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Rosella Musa, Paolo Ventura, Paolo Chiesi
  • Patent number: 7132115
    Abstract: The invention relates to carrier particles for use in pharmaceutical compositions for the pulmonary administration of medicaments by means of dry powder inhalers. In particular, the invention relates to a novel technological process for obtaining a carrier modified so as to improve the efficiency of redispersion of active particles and hence increase the respirable fraction. After the treatment of the invention, the surface of said modified carrier particles can also be coated with a suitable additive so as to further improve the respirable fraction.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: November 7, 2006
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Rossella Musa, Roberto Bilzi, Paolo Ventura, Paolo Chiesi
  • Patent number: 7053044
    Abstract: SP-C analogue artificial peptides having surface activity are disclosed and their use for preparing artificial surfactants useful in the treatment of respiratory distress syndrome (RDS) and other diseases related to surfactant deficiency or dysfunction.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: May 30, 2006
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Tore Curstedt, Jan Johansson, Hans J├Ârnvall, Paolo Ventura
  • Publication number: 20050142071
    Abstract: The invention relates to the use of pressurised metered dose inhalers (MDIs) having part or all of their internal surfaces consisting of stainless steel, anodised aluminium or lined with an inert organic coating; and to compositions to be delivered with said MDIs.
    Type: Application
    Filed: February 18, 2005
    Publication date: June 30, 2005
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: David Lewis, David Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
  • Publication number: 20050118113
    Abstract: Carrier particles, for use in the preparation of powdery mixtures for administration by inhalation, and having a median diameter of greater than 90 microns and a surface rugosity expressed as the fractal dimension of less than or equal to 1.1, may be prepared by subjecting particles having a median diameter of greater than 90 microns to repeated stages of wetting with a solvent and drying.
    Type: Application
    Filed: March 23, 2004
    Publication date: June 2, 2005
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Giovanni Caponetti, Pier Catellani, Ruggero Bettini, Paolo Colombo, Paolo Ventura