Patents by Inventor Parag V. Karmarkar
Parag V. Karmarkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11872086Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: GrantFiled: November 6, 2019Date of Patent: January 16, 2024Assignee: ClearPoint Neuro, Inc.Inventors: Parag V. Karmarkar, Kimble Jenkins
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Publication number: 20200078131Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: ApplicationFiled: November 6, 2019Publication date: March 12, 2020Inventors: Parag V. Karmarkar, Kimble Jenkins
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Patent number: 10492881Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: GrantFiled: April 20, 2017Date of Patent: December 3, 2019Assignee: MRI Interventions, Inc.Inventors: Parag V. Karmarkar, Kimble Jenkins
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Patent number: 10391307Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.Type: GrantFiled: November 15, 2016Date of Patent: August 27, 2019Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
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Patent number: 9763745Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: GrantFiled: April 22, 2015Date of Patent: September 19, 2017Assignee: MRI Interventions, Inc.Inventors: Parag V. Karmarkar, Kimble Jenkins
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Publication number: 20170215981Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: ApplicationFiled: April 20, 2017Publication date: August 3, 2017Inventors: Parag V. Karmarkar, Kimble Jenkins
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Publication number: 20170113036Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.Type: ApplicationFiled: November 15, 2016Publication date: April 27, 2017Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
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Methods and apparatus for fabricating leads with conductors and related flexible lead configurations
Patent number: 9630000Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: GrantFiled: February 1, 2016Date of Patent: April 25, 2017Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore -
Patent number: 9492651Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2W/kg. Related devices and methods of fabricating leads are also described.Type: GrantFiled: March 13, 2008Date of Patent: November 15, 2016Assignees: MRI Interventions, Inc., Boston Scientific Neuromodulation CorporationInventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
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METHODS AND APPARATUS FOR FABRICATING LEADS WITH CONDUCTORS AND RELATED FLEXIBLE LEAD CONFIGURATIONS
Publication number: 20160220812Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: ApplicationFiled: February 1, 2016Publication date: August 4, 2016Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore -
Patent number: 9248270Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.Type: GrantFiled: March 13, 2008Date of Patent: February 2, 2016Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Parag V. Karmarkar, Paul A. Bottomley, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore
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Publication number: 20150223905Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: ApplicationFiled: April 22, 2015Publication date: August 13, 2015Inventors: Parag V. Karmarkar, Kimble Jenkins
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Patent number: 9042958Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.Type: GrantFiled: November 29, 2006Date of Patent: May 26, 2015Assignee: MRI Interventions, Inc.Inventors: Parag V. Karmarkar, Kimble Jenkins
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Patent number: 8825133Abstract: An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length.Type: GrantFiled: January 24, 2013Date of Patent: September 2, 2014Assignee: MRI Interventions, Inc.Inventors: Kimble L. Jenkins, Peter Piferi, Kamal Vij, Daniele Ghidoli, Jesse Flores, Parag V. Karmarkar, Rajesh Pandey
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Patent number: 8688226Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: GrantFiled: April 29, 2013Date of Patent: April 1, 2014Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Edelstein, Parag V. Karmarkar
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Publication number: 20140024909Abstract: An MRI-compatible catheter reduces localized heating due to MR scanner-induced currents and includes a shaft having opposite distal and proximal end portions. One or more RF tracking coils are positioned adjacent the distal end portion and each includes a conductive lead that electrically connects the RF tracking coil to an MRI scanner. Each lead includes a series of back and forth segments along its length. The catheter includes one or more sensing electrodes at the shaft distal end portion, each electrically connected to a resistor having high impedance. A sheath surrounds a portion of the elongated shaft and includes at least one RF shield coaxially disposed therewithin. Each RF shield includes elongated inner and outer conductors and an elongated dielectric layer of MRI compatible material sandwiched between the inner and outer conductors. The inner and outer conductors are electrically connected at one end and electrically isolated at an opposite end.Type: ApplicationFiled: February 24, 2012Publication date: January 23, 2014Applicant: MRI INTERVENTIONS, INC.Inventors: Kamal Vij, Parag V. Karmarkar, Rajesh Pandey, Peter Piferi
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Publication number: 20130267832Abstract: Implantable aneurysm-sac treatment devices include an implantable coil body configured and sized to reside in a sac of an aneurysm. The body has an inductance and capacitance. The capacitance is selected so that the coil resonates at a Larmor frequency of a predefined magnetic field strength.Type: ApplicationFiled: November 6, 2012Publication date: October 10, 2013Inventors: Parag V. Karmarkar, Aravind Arepally
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Patent number: 8509876Abstract: In vivo medical stimulation probes include an elongate lead having at least one stimulation electrode disposed on a distal portion thereof. The probes may include a plurality of axially spaced apart RF chokes disposed on and/or in an axially extending shielding layer of the lead in advance of the at least one electrode to inhibit induced RF current from forming and/or traveling along the shielding layer.Type: GrantFiled: August 9, 2005Date of Patent: August 13, 2013Assignee: The Johns Hopkins UniversityInventor: Parag V. Karmarkar
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Patent number: 8433421Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.Type: GrantFiled: November 7, 2011Date of Patent: April 30, 2013Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Eldelstein, Parag V. Karmarkar
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Patent number: 8328862Abstract: Implantable aneurysm-sac treatment devices include an implantable coil body configured and sized to reside in a sac of an aneurysm. The body has an inductance and capacitance. The capacitance is selected so that the coil resonates at a Larmor frequency of a predefined magnetic field strength.Type: GrantFiled: October 4, 2006Date of Patent: December 11, 2012Assignee: The Johns Hopkins UniversityInventors: Parag V. Karmarkar, Aravind Arepally