Patents by Inventor Parameswaran Subrayan

Parameswaran Subrayan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050171063
    Abstract: The invention provides the use of phosphono derivatives of selected aliphatic acids represented by the structural formulae R—COOH, R being PO3H2 or CR1R2—PO3H2 where R1/R2 are H, OH, COOH or alkyl groups for the treatment of malaria. The use of the compound comprises administering an effective amount of said compounds for in vitro and in vivo studies using malarial parasites (Plasmodium falciparum and Plasmodium berghei).
    Type: Application
    Filed: July 16, 2004
    Publication date: August 4, 2005
    Inventors: Pawan Malhotra, Palakodeti Dasaradhi, Asif Mohammed, Manzar Hossain, Sunil Mukherji, Venkatasamy Manivel, Kanury Subba Rao, Parameswaran Subrayan, Anil Chatterji
  • Publication number: 20050090480
    Abstract: The invention provides the use of zinc complexes of selected amino acids from D or L isomers of proline, lysine, histidine, glycine, arginine and tryptophan or their various hydroxyl, amino, alkyl and carboxyl derivatives and zinc chloride, zinc acetate or other pharmacologically acceptable salts of zinc. The use of the compound comprises administering an effective amount of said compounds for inhibition of growth: of the malarial parasite, Plasmodium falciparum. The compound is lethal to the parasite in RBC cultures but have no effect on the RBCs. The compound has also displayed activity against, the chloroquine-resistant strain-W2Mef. The dose response curves for both 3D7 and W2Mef strains are identical which strongly suggested that the compound is equally effective against field isolates of chloroquine-resistant, P. falciparum. The compound acts on W2Mef strain through killing the target.
    Type: Application
    Filed: July 19, 2004
    Publication date: April 28, 2005
    Applicant: Council of Scientific & Industrial Research
    Inventors: Pawan Malhotra, Palakodeti Venkata Dasaradhi, Asif Mohammed, Manzar Hossain, Sunil Mukherji, Manivel Venkatasamy, Kanury Rao, Gyan Mishra, Parameswaran Subrayan, Anil Chatterji
  • Publication number: 20050085547
    Abstract: The present invention is related to compounds having general formula Z-OC(CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, for modulation of immune response by differentiation dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—C(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1(NHR2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn.
    Type: Application
    Filed: December 31, 2003
    Publication date: April 21, 2005
    Applicant: Council of Scientific & Industrial Research
    Inventors: Anil Chatterji, Krishnamurthy Natarajan, Venkatasamy Manivel, Kanury Subba Rao, Parameswaran Subrayan, Vinod Singh, Ramasamy Anand, Ehrlich Desa
  • Publication number: 20050085546
    Abstract: The present invention is related to compounds having general formula Z-OC (CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—CR1(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1N2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn.
    Type: Application
    Filed: December 31, 2003
    Publication date: April 21, 2005
    Applicant: Council of Scientific & Industrial Research
    Inventors: Anil Chatterji, Krishnamurthy Natarajan, Venkatasamy Manivel, Kanury Venkata Subba Rao, Parameswaran Subrayan, Vinod Singh, Ramasamy Anand, Ehrlich Desa
  • Publication number: 20050085537
    Abstract: This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.
    Type: Application
    Filed: December 30, 2003
    Publication date: April 21, 2005
    Applicant: Council of Scientific & Industrial Research
    Inventors: Kanury Rao, Mohan Wani, Venkatasamy Manivel, Parameswaran Subrayan, Vinod Singh, Ramasamy Anand, Ehrlich Desa, Gyan Mishra, Anil Chatterji
  • Patent number: 6667062
    Abstract: The present invention relates to a composition useful as an anti-fouling agent by inhibiting microbial growth, said comprising extract and/or its fractions from Zoanthus sp. and optionally de-odorizing agents and a method of producing said extract and its fractions having about 100% anti-bacterial activity fouling microbes.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: December 23, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Cynthia Olimpia Lydia Gonsalves, Chittur Thelakkat Achuthankutty, Perunninakulath Parameswaran Subrayan, Chandrakant Govind Naik
  • Publication number: 20030185897
    Abstract: The present invention relates to a composition useful as an anti-fouling agent by inhibiting microbial growth, said composition comprising extract and/or its fractions from Zoanthus sp. and optionally de-odorizing agents and a method of producing said extract and its fractions having about 100% anti-bacterial activity fouling microbes.
    Type: Application
    Filed: March 27, 2002
    Publication date: October 2, 2003
    Applicant: Council of Scientific and Industrial Research
    Inventors: Cynthia Olimpia Lydia Gonsalves, Chittur Thelakkat Achuthankutty, Perunninakulath Parameswaran Subrayan, Chandrakant Govind Naik
  • Patent number: 6617319
    Abstract: The invention provides a process for the isolation of 2-deoxy ecdysterone from Zoanthus sp process comprising the steps (a) preparing crude methanol extract of Zoanthus sp., (b) subjecting the crude methanol extract to fractionation using petroleum ether, ethyl acetate, chloroform, n-butanol and mixtures thereof to yield a fraction, (c) subjecting the active fraction to flash chromatography over silica gel to obtain partially purified active compound, and (d) subjecting the active subfraction obtained from step (c) above to gel permeation chromatography to obtain the active pure compound.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: September 9, 2003
    Assignee: Council of Science and Industrial Research
    Inventors: Cynthia Olimpia Lydia Gonsalves, Perunninakulath Parameswaran Subrayan, Chandrakant Govind Naik, Chittur Thelakkat Achuthankutty
  • Publication number: 20020147355
    Abstract: The invention provides a process for the isolation of 2-deoxy ecdysterone from Zoanthus sp process comprising the steps (a) preparing crude methanol extract of Zoanthus sp., (b)subjecting the crude methanol extract to fractionation using petroleum ether, ethyl acetate, chloroform, n-butanol and mixtures thereof to yield a fraction, (c) subjecting the active fraction to flash chromatography over silica gel to obtain partially purified active compound, and (d) subjecting the active subfraction obtained from step (c) above to gel permeation chromatography to obtain the active pure compound.
    Type: Application
    Filed: January 16, 2002
    Publication date: October 10, 2002
    Inventors: Cynthia Olimpia Lydia Gonsalves, Perunninakulath Parameswaran Subrayan, Chandrakant Govind Naik, Chittur Thelakkat Achuthankutty