Patents by Inventor Parisa Yousefpour

Parisa Yousefpour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220022947
    Abstract: A method for destroying a cancerous tumor. The method includes putting two electrodes of an electrical probe in contact with a portion of the cancerous tumor, plotting an impedance phase diagram by measuring a set of electrical impedance phase values from the portion of the cancerous tumor at end of a respective set of pre-determined time steps, destroying cancer cells of the portion of the cancerous tumor within each time step of the respective set of pre-determined time steps by electrolyzing peripheral medium surrounding the cancer cells of the portion of the cancerous tumor by applying a direct current (DC) voltage between the two electrodes, and stopping destroying of the cancer cells responsive to a complete destruction of the portion of the cancerous tumor, where the complete destruction includes obtaining a positive slope of the impedance phase diagram (IPS).
    Type: Application
    Filed: October 3, 2021
    Publication date: January 27, 2022
    Applicant: Nano Hesgarsazan Salamat Arya
    Inventors: Mohammad Abdolahad, Reyhaneh Mahdavi, Mohammad Ali Khayamian, Parisa Aghaee, Hadi Ghafari, Naser Namdar Habashi, Fereshteh Abbasvandi, Zohreh Sadat Miripour, Narges Yousefpour, Hossein Ataee, Sajad Mehrvarz
  • Publication number: 20220022946
    Abstract: A system for destroying a cancerous tumor. The system includes an electrical probe, an impedance analyzer device configured to be connected to the electrical probe, a DC voltage generator configured to be connected to the electrical probe, and a processing unit connected to the impedance analyzer device and the DC voltage generator. The electrical probe includes a first electrode including a first electrically conductive needle, a second electrode including a second electrically conductive needle with a nanoporous surface placed inside the first electrode, a first electrically insulating layer placed around the first electrode except a first distal end portion of the first electrode, and a second electrically insulating layer placed between the first electrode and the second electrode. The processing unit configured to perform destroying the cancerous tumor by executing processor-readable instructions utilizing the impedance analyzer device and the DC voltage generator.
    Type: Application
    Filed: October 3, 2021
    Publication date: January 27, 2022
    Applicant: Nano Hesgarsazan Salamat Arya
    Inventors: Mohammad Abdolahad, Zohreh Sadat Miripour, Mohammad Ali Khayamian, Parisa Aghaee, Hadi Ghafari, Naser Namdar Habashi, Fereshteh Abbasvandi, Reyhaneh Mahdavi, Narges Yousefpour, Hossein Ataee, Sajad Mehrvarz
  • Publication number: 20210324413
    Abstract: Genetic circuits have been developed to regulate behaviors of replicon RNA in responses to small molecules, which has broader applications, such as for quantitative expression of cargo genes, temporary expression of immunomodulatory cytokines or antigens for better cancer immunotherapy or vaccination, and for increased safety in use of self-replicating vectors or in combination with other viral-delivery vectors. Described herein are genetic circuits suitable for systems that either require a tight off state or a slow off state, which can serve for instance where either a kill switch or prolonged protein expression (e.g., of vaccine antigens) are needed.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Darrell J. Irvine, Ron Weiss, Yingzhong Li, Jan Lonzaric, Parisa Yousefpour
  • Publication number: 20210316007
    Abstract: Described herein are compositions that include an assembly of self-assembling conjugates. The self-assembling conjugates may include a polypeptide having a transition temperature (17) above 50° C. when the polypeptide is not attached to the conjugate, an albumin binding domain (ABD) attached to a first end of the polypeptide, and at least one molecule attached to a second end of the polypeptide through a cysteine group, wherein the molecule has an octanol-water distribution coefficient (log D) of greater than or equal to 1.5 at a pH of 7.4 when the molecule is not attached to the conjugate. Also described herein are methods of using the compositions.
    Type: Application
    Filed: September 6, 2019
    Publication date: October 14, 2021
    Inventors: Parisa Yousefpour, Ashutosh Chilkoti
  • Publication number: 20210060171
    Abstract: Described herein are albumin binding peptide drug (AlBiPeD) conjugates comprising a small molecule linked to an albumin binding domain (ABD) via a pH-sensitive linker and methods of purifying and using the same.
    Type: Application
    Filed: January 25, 2019
    Publication date: March 4, 2021
    Inventors: Ashutosh Chilkoti, Parisa Yousefpour
  • Publication number: 20180228908
    Abstract: Provided herein are conjugates including a polypeptide and one or more drug molecules. The polypeptide includes one or more charged motifs, and may further include one or more uncharged motifs. The conjugates may be used to effectively deliver the drug molecule to a subject.
    Type: Application
    Filed: August 4, 2016
    Publication date: August 16, 2018
    Inventors: Ashutosh Chilkoti, Samagya Banskota, Parisa Yousefpour, Jayanta Bhattacharyya