Patents by Inventor Partha P. Mitra

Partha P. Mitra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11169056
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: November 9, 2021
    Assignee: Clarapath, Inc.
    Inventors: Partha P. Mitra, Baris Yagci, Cong Zhang
  • Publication number: 20210263055
    Abstract: The present disclosure also relates to systems and methods for quality control in histology systems. In some embodiments, a method is provided that includes receiving a tissue block comprising a tissue sample embedded in an embedding material, imaging the tissue block to create a first imaging data of the tissue sample in a tissue section on the tissue block, removing the tissue section from the tissue block, the tissue section comprising a part of the tissue sample, imaging the tissue section to create a second imaging data of the tissue sample in the tissue section, and comparing the first imaging data to the second imaging data to confirm correspondence in the tissue sample in the first imaging data and the second imaging data based on one or more quality control parameters.
    Type: Application
    Filed: February 22, 2021
    Publication date: August 26, 2021
    Inventors: Partha P. Mitra, Charles Cantor, Baris Yagci, David Kleinfeld, Cong Zhang
  • Publication number: 20210262907
    Abstract: The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.
    Type: Application
    Filed: February 22, 2021
    Publication date: August 26, 2021
    Inventors: Partha P. Mitra, Charles Cantor, Baris Yagci, David Kleinfeld, Cong Zhang, Steven Smith
  • Publication number: 20210262905
    Abstract: The present disclosure relates to systems and methods for tracking and printing within a histology system. In some embodiments, a system is provided that includes an information reader configured to read identifying data associated with a tissue block, a microtome configured to cut one or more tissue sections from the tissue block, one or more slides for receiving the one or more tissue sections, and a printer configured to receive the identifying data and print, after the one or more tissue sections are cut from the tissue block, one or more labels for the one or more slides, the one or more labels comprising information associating the one more tissue sections on the one or more slides with the tissue block.
    Type: Application
    Filed: February 22, 2021
    Publication date: August 26, 2021
    Inventors: Partha P. Mitra, Janak Sewkarran, Baris Yagci, Jerry R. Pinto
  • Publication number: 20210104295
    Abstract: Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
    Type: Application
    Filed: September 14, 2020
    Publication date: April 8, 2021
    Inventor: Partha P. Mitra
  • Publication number: 20210063288
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Application
    Filed: July 27, 2020
    Publication date: March 4, 2021
    Inventors: Partha P. Mitra, Baris Yagci, Cong Zhang
  • Patent number: 10796781
    Abstract: Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 6, 2020
    Assignee: Clarapath, Inc.
    Inventor: Partha P. Mitra
  • Patent number: 10724929
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Grant
    Filed: May 6, 2017
    Date of Patent: July 28, 2020
    Assignee: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20200166434
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 28, 2020
    Applicant: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20200064232
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Application
    Filed: November 1, 2019
    Publication date: February 27, 2020
    Applicant: Clarapath, Inc.
    Inventors: Partha P. Mitra, Alexander S. Tolpygo, Robert L. Kleinberg
  • Patent number: 10571368
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: February 25, 2020
    Assignee: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Patent number: 10473557
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 12, 2019
    Assignee: Clarapath, Inc.
    Inventors: Partha P. Mitra, Alexander S. Tolpygo, Robert L. Kleinberg
  • Patent number: 10446260
    Abstract: The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalog of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the cataloged three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 15, 2019
    Assignee: Clarapath, Inc.
    Inventor: Partha P. Mitra
  • Publication number: 20170328818
    Abstract: A method and apparatus for automatically transferring sections from a sample block to a tape and for transferring select sections to a slide. A tissue storage system for storing cut sections on the tape and digital storage system for storing photos and other information during the transfer of the sections can also be provided, thereby creating a tissue repository and data repository for future use.
    Type: Application
    Filed: May 6, 2017
    Publication date: November 16, 2017
    Applicant: Clarapath, Inc.
    Inventors: Cong Zhang, Mark Fasciano, Partha P. Mitra
  • Publication number: 20170205317
    Abstract: An automated tape transfer apparatus including a tape feed mechanism feeding a continuous length of an adhesive tape through the automated tape transfer apparatus and a tape applicator applying the adhesive tape to a cutting face of a sample block, wherein a section of the sample block is adhered to the adhesive tape after cutting of the section from the sample block. A slide station transfers the cut section from the adhesive tape to a slide.
    Type: Application
    Filed: April 1, 2017
    Publication date: July 20, 2017
    Applicant: Clarapath, Inc.
    Inventors: CONG ZHANG, Mark Fasciano, Partha P. Mitra
  • Publication number: 20170161428
    Abstract: Three dimensional tumor volume is analyzed spatially by genomics and transcriptomics, or both. Thin sections are cut with a microtome using a tape transfer technique so that the thin tissue sections remain without any distortion or deformation, in sequence relative to their position in the original tissue, so that a three-dimensional coordinate system can be anchored to each tissue section. Small samples of tissue are extracted or punched from very precise locations in the supports using the coordinate system as a grid, with known x,y,z location, and subjected to genomic sequencing. Sequence data is analyzed using the three dimensional coordinate system, so that the original tissue is thereby analyzed as a three dimensional system volume. At the same time, alternate tissue sections (or the same sections from which samples have been extracted with sample punches) can be subjected to staining and imaging to do histochemical analysis.
    Type: Application
    Filed: April 15, 2016
    Publication date: June 8, 2017
    Inventor: Partha P. Mitra
  • Publication number: 20170160535
    Abstract: The invention is directed to a preserved serial set of sequential, iterative, and ordered thin sections of a specimen block, and a catalogue of images taken from one or more sub-series of the set of sections and organized so as to create a three-dimensional profile of the microscopic structures of the specimen block. The serial set of sequential, iterative, and ordered thin sections are prepared from the specimen block by cutting and imaging thin sections of that specimen block so that the thin sections remain strictly in the sequential, iterative, order in which they are cut from the specimen block. A spatial index is created from the catalogued three-dimensional images which is searchable by local content-based image retrieval (LCBIR). The LCBIR query is used to locate, within the three-dimensional index, microscopic structural features, thereby making that portion of the specimen available for further analysis and/or for extraction.
    Type: Application
    Filed: April 15, 2016
    Publication date: June 8, 2017
    Inventor: Partha P. Mitra
  • Publication number: 20170003309
    Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.
    Type: Application
    Filed: June 10, 2016
    Publication date: January 5, 2017
    Applicant: Clarapath, Inc.
    Inventors: PARTHA P. MITRA, Alexander S. Tolpygo, Robert L. Kleinberg
  • Patent number: 8625691
    Abstract: This inventions provides techniques for estimating both temporal and spectral channel fluctuations with the duration of a data symbol. Certain pulse shaping functions are Discrete Prolate Spheroidal Sequences (DPSSs) and are used primarily because of their relatively limited Inter-Symbol Interference (ISI) properties. During reception, these properties allow one or more parameters of a joint time-frequency channel model to be more easily determined. Once the one or more parameters are determined, they can be applied to received symbols to correct the temporal fluctuations, spectral fluctuations, or both of the channel over which a communication took place. The techniques may be adapted for the Multiple-In, Multiple-Out communication situation.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: January 7, 2014
    Assignee: Alcatel Lucent
    Inventors: Michael R. Andrews, Partha P. Mitra, Karin Sigloch, David J. Thomson
  • Publication number: 20100160172
    Abstract: Methods and systems of DNA sequencing that compensate for sources of noise in next-generation DNA sequencers are described.
    Type: Application
    Filed: July 6, 2009
    Publication date: June 24, 2010
    Applicant: Cold Spring Harbor Laboratory
    Inventors: Yaniv Erlich, Partha P. Mitra, Gregory J. Hannon