Patents by Inventor Patrick Seamus Doyle

Patrick Seamus Doyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9910352
    Abstract: In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse. An article of manufacture includes a non-spheroidal polymeric microstructure that has a plurality of distinct material regions.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: March 6, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Seamus Doyle, Daniel Colin Pregibon, Dhananjay Dendukuri
  • Publication number: 20170306103
    Abstract: Techniques are provided to independently control 3D shape and chemistry of rapidly produced colloids. A pre-polymer mixture including a monomer is made to flow into a channel with insular relief in a wall at a known location of the channel. A stimulus that polymerizes the pre-polymer mixture is directed onto the known location to form a structure locked in place at the known location by the insular relief. A pressure is applied to the channel that is sufficient to deflect the wall having the insular relief sufficiently to release a hydrogel particle comprising the structure.
    Type: Application
    Filed: December 2, 2016
    Publication date: October 26, 2017
    Inventors: Ki Wan Bong, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Patent number: 9512278
    Abstract: Techniques are provided to independently control 3D shape and chemistry of rapidly produced colloids. A pre-polymer mixture including a monomer is made to flow into a channel with insular relief in a wall at a known location of the channel. A stimulus that polymerizes the pre-polymer mixture is directed onto the known location to form a structure locked in place at the known location by the insular relief. A pressure is applied to the channel that is sufficient to deflect the wall having the insular relief sufficiently to release a hydrogel particle comprising the structure.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: December 6, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Ki Wan Bong, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Publication number: 20150234270
    Abstract: In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse. An article of manufacture includes a non-spheroidal polymeric microstructure that has a plurality of distinct material regions.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Patrick Seamus Doyle, Daniel Colin Pregibon, Dhananjay Dendukuri
  • Patent number: 8535644
    Abstract: Techniques are provided to produce and use non-spherical colloidal particles with independently tuned size, shape, flexibility, and chemical properties. A pre-polymer mixture for forming hydrogel particles includes a percentage of PEGDA selected to impart a target stiffness to the particles and includes, a percentage of acrylic acid selected to impart an independent target chemical function to the particles. The mixture also includes a percentage of photo-initiator to polymerize PEGDA upon exposure to a light source to impart an independently selected target size or shape or both to the particles.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: September 17, 2013
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Ramin Haghgooie, Patrick Seamus Doyle, Mehmet Toner, Daniel Colin Pregibon
  • Patent number: 8252517
    Abstract: Stop flow interference lithography system for high throughput synthesis of 3-dimensionally patterned polymer particles. The system includes a microfluidic channel containing a stationary oligomer film and a phase mask located adjacent to the microfluidic channel. A source of collimated light is provided for passing the collimated light through the phase mask and into the microfluidic channel for interaction with the oligomer. The passage of the collimated light through the phase mask generates a 3-dimensional distribution of light intensity to induce crosslinking of the oligomer in high intensity regions thereby forming 3-dimensional structures.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: August 28, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Edwin L. Thomas, Patrick Seamus Doyle, Dhananjay Dendukuri, Ji-Hyun Jang, Chaitanya K. Ullal
  • Publication number: 20120135235
    Abstract: Techniques are provided to independently control 3D shape and chemistry of rapidly produced colloids. A pre-polymer mixture including a monomer is made to flow into a channel with insular relief in a wall at a known location of the channel. A stimulus that polymerizes the pre-polymer mixture is directed onto the known location to form a structure locked in place at the known location by the insular relief. A pressure is applied to the channel that is sufficient to deflect the wall having the insular relief sufficiently to release a hydrogel particle comprising the structure.
    Type: Application
    Filed: October 21, 2009
    Publication date: May 31, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Ki Wan Bong, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Publication number: 20120107820
    Abstract: Certain embodiments of the present invention are directed to one pot multiplexed quantitative PCR methods for end point analysis of a plurality of nucleic acid targets in a complex sample without user intervention, and to various encoded particles on which are immobilized one or more probes that hybridize with the plurality of targets. Certain other embodiments are directed to a new “multiple-color genetic variation detection method” that can detect SNPs and kit using one chamber multiplexed endpoint PCR and differentially labeled allele-specific primers (one recognizing only the wild type allele and one only the mutant allele).
    Type: Application
    Filed: January 13, 2012
    Publication date: May 3, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Daniel Colin Pregibon, Patrick Seamus Doyle
  • Publication number: 20120003755
    Abstract: Techniques are provided for high precision scanning of hydrogel microparticles. The high precision is achieved by one or more modifications to the microparticle composition, or microfluidics apparatus that align the microparticles in a detection channel, or method of preparing a sample for introduction into the apparatus, or some combination. An apparatus comprises a body structure having formed therein a central channel and multiple focusing channels in fluid communication with the central channel through multiple junctions. A width of the central channel is smaller in a portion downstream of each junction. A particle comprises a hydrogel matrix and a probe molecule. The particle has an aspect ratio greater than about three. A method includes loading into a sample fluid inlet a mixture, wherein a number of particles lies within a range from about 5 to about 10 particles/?l.
    Type: Application
    Filed: September 12, 2011
    Publication date: January 5, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Stephen C. Chapin, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Patent number: 8034629
    Abstract: Techniques are provided for high precision scanning of hydrogel microparticles. The high precision is achieved by one or more modifications to the microparticle composition, or microfluidics apparatus that align the microparticles in a detection channel, or method of preparing a sample for introduction into the apparatus, or some combination. An apparatus comprises a body structure having formed therein a central channel and multiple focusing channels in fluid communication with the central channel through multiple junctions. A width of the central channel is smaller in a portion downstream of each junction. A particle comprises a hydrogel matrix and a probe molecule. The particle has an aspect ratio greater than about three. A method includes loading into a sample fluid inlet a mixture, wherein a number of particles lies within a range from about 15 to about 20 particles/?l.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: October 11, 2011
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen C. Chapin, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Publication number: 20110136104
    Abstract: Certain embodiments of the present invention are directed to one pot multiplexed quantitative PCR methods for end point analysis of a plurality of nucleic acid targets in a complex sample without user intervention, and to various encoded particles on which are immobilized one or more probes that hybridize with the plurality of targets. Certain other embodiments are directed to a new “multiple-color genetic variation detection method” that can detect SNPs and kit using one chamber multiplexed endpoint PCR and differentially labeled allele-specific primers (one recognizing only the wild type allele and one only the mutant allele).
    Type: Application
    Filed: December 4, 2009
    Publication date: June 9, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Colin Pregibon, Patrick Seamus Doyle
  • Publication number: 20100330693
    Abstract: Techniques are provided for high precision scanning of hydrogel microparticles. The high precision is achieved by one or more modifications to the microparticle composition, or microfluidics apparatus that align the microparticles in a detection channel, or method of preparing a sample for introduction into the apparatus, or some combination. An apparatus comprises a body structure having formed therein a central channel and multiple focusing channels in fluid communication with the central channel through multiple junctions. A width of the central channel is smaller in a portion downstream of each junction. A particle comprises a hydrogel matrix and a probe molecule. The particle has an aspect ratio greater than about three. A method includes loading into a sample fluid inlet a mixture, wherein a number of particles lies within a range from about 15 to about 20 particles/?l.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 30, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Stephen C. Chapin, Patrick Seamus Doyle, Daniel Colin Pregibon
  • Publication number: 20100099048
    Abstract: Stop flow interference lithography system for high throughput synthesis of 3-dimensionally patterned polymer particles. The system includes a microfluidic channel containing a stationary oligomer film and a phase mask located adjacent to the microfluidic channel. A source of collimated light is provided for passing the collimated light through the phase mask and into the microfluidic channel for interaction with the oligomer. The passage of the collimated light through the phase mask generates a 3-dimensional distribution of light intensity to induce crosslinking of the oligomer in high intensity regions thereby forming 3-dimensional structures.
    Type: Application
    Filed: July 16, 2009
    Publication date: April 22, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Edwin L. Thomas, Patrick Seamus Doyle, Dhananjay Dendukuri, Ji-Hyun Jang, Chaitanya K. Ullal
  • Publication number: 20100092393
    Abstract: Techniques are provided to produce and use non-spherical colloidal particles with independently tuned size, shape, flexibility, and chemical properties. A pre-polymer mixture for forming hydrogel particles includes a percentage of PEGDA selected to impart a target stiffness to the particles and includes, a percentage of acrylic acid selected to impart an independent target chemical function to the particles. The mixture also includes a percentage of photo-initiator to polymerize PEGDA upon exposure to a light source to impart an independently selected target size or shape or both to the particles.
    Type: Application
    Filed: October 13, 2009
    Publication date: April 15, 2010
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Ramin Haghgooie, Patrick Seamus Doyle, Mehmet Toner, Daniel Colin Pregibon