Patents by Inventor Paul A. Aristoff
Paul A. Aristoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10858360Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: July 7, 2017Date of Patent: December 8, 2020Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Publication number: 20170369498Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: July 7, 2017Publication date: December 28, 2017Applicants: Merck Sharp & Dohme Corp., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Patent number: 9732083Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: GrantFiled: March 14, 2012Date of Patent: August 15, 2017Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Publication number: 20120238751Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: March 14, 2012Publication date: September 20, 2012Applicant: TRIUS THERAPEUTICS, INC.Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Patent number: 6060600Abstract: This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.Type: GrantFiled: September 17, 1997Date of Patent: May 9, 2000Assignee: Pharmacia & Upjohn CompanyInventors: Robert A. Chruscial, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe
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Patent number: 5977169Abstract: This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by the formula below.Type: GrantFiled: July 28, 1997Date of Patent: November 2, 1999Inventors: Robert A. Chrusciel, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe, Gordon L. Bundy
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Patent number: 5972922Abstract: Novel angiostatic .DELTA..sup.4,9(11) -steroids (I), ##STR1## C.sub.21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are useful in treating diseases of neovascularization such as cancer, diabetes and arthritis.Type: GrantFiled: December 21, 1995Date of Patent: October 26, 1999Assignee: Alcon Laboratories, Inc.Inventors: John W. Wilks, Thomas F. DeKoning, Paul A. Aristoff
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Patent number: 5739350Abstract: This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignee: Pharmacia & Upjohn CompanyInventors: Robert C. Kelly, Mark A. Mitchell, Paul A. Aristoff
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Patent number: 5563142Abstract: The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus.Type: GrantFiled: February 22, 1994Date of Patent: October 8, 1996Assignee: The Upjohn CompanyInventors: John R. Palmer, Donna L. Romero, Paul A. Aristoff, Richard C. Thomas, Herman W. Smith
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Patent number: 5541339Abstract: This invention concerns chemical compounds of general Formula ICPI.sub.1 -R.sub.5 -T-R'.sub.5 -CPI.sub.2 IThe compounds of Formula I are useful as uv light absorbers, antibacterial agents, and are particularly useful as antitumor agents. Representative compounds of Formula I have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.Type: GrantFiled: March 8, 1991Date of Patent: July 30, 1996Assignee: The Upjohn CompanyInventors: Robert C. Kelly, Paul A. Aristoff
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Patent number: 5489593Abstract: The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).Type: GrantFiled: December 2, 1994Date of Patent: February 6, 1996Assignee: The Upjohn CompanyInventors: John R. Palmer, Paul A. Aristoff, Donna L. Romero
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Patent number: 5332837Abstract: This invention concerns 2-acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula I': ##STR1## the compounds of Formula I' are useful as uv light absorber substances, as chemical intermediates and as prodrugs of known spirocyclopropylpyrroloindole CC-1065 analogs. Representative Formula I' compounds have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.Type: GrantFiled: January 22, 1993Date of Patent: July 26, 1994Assignee: The Upjohn CompanyInventors: Robert C. Kelly, David G. Martin, Paul A. Aristoff
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Patent number: 5238954Abstract: A fluorinated flavone acetic acid suitable for use as an antitumor agent. Pharmaceutical compositions comprising the fluorinated flavone acetic acid and a pharmaceutically acceptable carrier. An antitumor composition comprising an antitumor effective amount of a fluorinated flavone acetic acid in a pharmaceutically acceptable carrier.Type: GrantFiled: July 18, 1991Date of Patent: August 24, 1993Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4975537Abstract: Disclosed are .DELTA..sup.9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as well as other abnormalities.Type: GrantFiled: May 15, 1989Date of Patent: December 4, 1990Assignee: The Upjohn CompanyInventors: Paul A. Aristoff, Harvey I. Skulnick, Wendell Wierenga
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Patent number: 4683330Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.Type: GrantFiled: January 11, 1985Date of Patent: July 28, 1987Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4668814Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.Type: GrantFiled: January 11, 1985Date of Patent: May 26, 1987Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4628110Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: October 30, 1984Date of Patent: December 9, 1986Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4590297Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: March 8, 1985Date of Patent: May 20, 1986Assignee: The Upjohn CompanyInventors: Paul A. Aristoff, John C. Sih
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Patent number: 4588823Abstract: Novel compounds of the following general formula: ##STR1##Type: GrantFiled: September 27, 1984Date of Patent: May 13, 1986Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4544764Abstract: The compound 15-cyclohexyl-9-deoxy-13,14-dihydro-2',9.alpha.-methano-3-oxa-4,5,6,16,17, 18,19,20-octanor-3,7(1',3-interphenylene)PGF.sub.1 and pharmacologically acceptable salts thereof.Type: GrantFiled: July 18, 1984Date of Patent: October 1, 1985Assignee: The Upjohn CompanyInventor: Paul A. Aristoff