Patents by Inventor Paul A. Aristoff

Paul A. Aristoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10858360
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: December 8, 2020
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Publication number: 20170369498
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: July 7, 2017
    Publication date: December 28, 2017
    Applicants: Merck Sharp & Dohme Corp., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh T. Lam, Suk J. Lee, Xiaoming Li, Douglas W. Phillipson, Leslie W. Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Patent number: 9732083
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: August 15, 2017
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Publication number: 20120238751
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Application
    Filed: March 14, 2012
    Publication date: September 20, 2012
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
  • Patent number: 6060600
    Abstract: This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: May 9, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Robert A. Chruscial, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe
  • Patent number: 5977169
    Abstract: This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by the formula below.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: November 2, 1999
    Inventors: Robert A. Chrusciel, Linda L. Maggiora, Suvit Thaisrivongs, James M. Tustin, Clark W. Smith, Ruben A. Tommasi, Paul A. Aristoff, Harvey I. Skulnick, W. Jeffrey Howe, Gordon L. Bundy
  • Patent number: 5972922
    Abstract: Novel angiostatic .DELTA..sup.4,9(11) -steroids (I), ##STR1## C.sub.21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids are useful in treating diseases of neovascularization such as cancer, diabetes and arthritis.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: October 26, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: John W. Wilks, Thomas F. DeKoning, Paul A. Aristoff
  • Patent number: 5739350
    Abstract: This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 14, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Robert C. Kelly, Mark A. Mitchell, Paul A. Aristoff
  • Patent number: 5563142
    Abstract: The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: October 8, 1996
    Assignee: The Upjohn Company
    Inventors: John R. Palmer, Donna L. Romero, Paul A. Aristoff, Richard C. Thomas, Herman W. Smith
  • Patent number: 5541339
    Abstract: This invention concerns chemical compounds of general Formula ICPI.sub.1 -R.sub.5 -T-R'.sub.5 -CPI.sub.2 IThe compounds of Formula I are useful as uv light absorbers, antibacterial agents, and are particularly useful as antitumor agents. Representative compounds of Formula I have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: July 30, 1996
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Paul A. Aristoff
  • Patent number: 5489593
    Abstract: The present invention includes diaromatic substituted heterocyclic compounds (III) ##STR1## which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: February 6, 1996
    Assignee: The Upjohn Company
    Inventors: John R. Palmer, Paul A. Aristoff, Donna L. Romero
  • Patent number: 5332837
    Abstract: This invention concerns 2-acyl-4,5,8,8a-tetrahydro-4-oxycyclopropan[c]pyrrol(3,2-e) indole derivatives of Formula I': ##STR1## the compounds of Formula I' are useful as uv light absorber substances, as chemical intermediates and as prodrugs of known spirocyclopropylpyrroloindole CC-1065 analogs. Representative Formula I' compounds have been shown to possess useful ranges of antitumor activity in standard laboratory animal tests.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: July 26, 1994
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, David G. Martin, Paul A. Aristoff
  • Patent number: 5238954
    Abstract: A fluorinated flavone acetic acid suitable for use as an antitumor agent. Pharmaceutical compositions comprising the fluorinated flavone acetic acid and a pharmaceutically acceptable carrier. An antitumor composition comprising an antitumor effective amount of a fluorinated flavone acetic acid in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: August 24, 1993
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4975537
    Abstract: Disclosed are .DELTA..sup.9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as well as other abnormalities.
    Type: Grant
    Filed: May 15, 1989
    Date of Patent: December 4, 1990
    Assignee: The Upjohn Company
    Inventors: Paul A. Aristoff, Harvey I. Skulnick, Wendell Wierenga
  • Patent number: 4683330
    Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: July 28, 1987
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4668814
    Abstract: A compound of the formula ##STR1## and intermediates useful in preparing same.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: May 26, 1987
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4628110
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: October 30, 1984
    Date of Patent: December 9, 1986
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4590297
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: May 20, 1986
    Assignee: The Upjohn Company
    Inventors: Paul A. Aristoff, John C. Sih
  • Patent number: 4588823
    Abstract: Novel compounds of the following general formula: ##STR1##
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: May 13, 1986
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff
  • Patent number: 4544764
    Abstract: The compound 15-cyclohexyl-9-deoxy-13,14-dihydro-2',9.alpha.-methano-3-oxa-4,5,6,16,17, 18,19,20-octanor-3,7(1',3-interphenylene)PGF.sub.1 and pharmacologically acceptable salts thereof.
    Type: Grant
    Filed: July 18, 1984
    Date of Patent: October 1, 1985
    Assignee: The Upjohn Company
    Inventor: Paul A. Aristoff