Abstract: This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: A method for cleaning an endoscopic instrument of a robotic surgical system includes, in response to receiving an input to effectuate a cleaning of the endoscopic instrument, robotically retracting the endoscopic instrument from a patient; and robotically moving an elongated shaft of the endoscopic instrument, relative to a longitudinal axis of the endoscopic instrument, from an unarticulated position to an articulated position after the elongated shaft of the endoscopic instrument is fully withdrawn from the patient.

Abstract: A computer-implemented method is provided for detecting actionable transaction risks. The method includes grouping an inbound event related to a transaction with a target event group and determining an actionable group of events that are deemed high risk and a non-actionable group of non-actionable events that are deemed low risk. The method also includes evaluating the target event group relative to the actionable and non-actionable groups of events. This includes computing a first distance between the target event group and the non-actionable group and a second distance between the target event group and actionable group. The first distance is compared with the second distance to determine if the target event group, including the inbound event, is closer to the actionable group or to the nonactionable group.

Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: Systems, apparatuses and methods provides for technology that generates, with a phased array of elements of an antenna system, an array element radiation pattern over a scan angle range, where the phased array of elements is spaced at a predetermined wavelength spacing. The technology reflects, with a reflector of the antenna system, the array element radiation pattern emitted from the phased array of elements to Earth, and establishes, based on a shape of the reflector, a predetermined magnification as a function of scan angle range so as to increase the field-of-view of the antenna system. The technology adjusts, based on the shape of the reflector, the array element radiation pattern, by increasing magnification relative to the scan angle range, to have a gain that increases with increases in scan angle relative to a boresight of the antenna system, and reflects, with the reflector, radiation from Earth to the phased array of elements.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain uracil derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.

Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

Abstract: A nip guard (10) for use with a conveyor system which includes a pulley (84) and a flexible conveyor belt (88) which is engaged with and which passes over the pulley (84), the conveyor belt (88) including an outer load-carrying surface (82) and an inner surface (86), wherein the nip guard (10) includes supporting structure (64, 66, 60) and, mounted to the supporting structure (60, 64, 66), at least one belt scraping element (46) configured to be in scraping contact with the inner surface (86) of the belt (88).

Abstract: A near-field test system for a phased array antenna includes a probe, a beam forming network, and a computing system. The probe is disposed at a fixed position in a near-field of the phased array antenna and transmits a test beam toward a fixed location on the phased array. The beam forming network is coupled to the phased array and includes a plurality of phase shifters and a beam summer. The phase shifters steer received beams for each antenna element of the phased array to form a planar wave front. The beam summer is coupled to the phase shifters and combines power of the received beams. The computing system is coupled to the beam forming network and scales combined power of the received beams and generates a virtual spectrum for the phased array antenna from scaled power of the received beams.

Abstract: Systems, apparatuses and methods provides for technology that generates, with a phased array of elements of an antenna system, an array element radiation pattern over a scan angle range, where the phased array of elements is spaced at a predetermined wavelength spacing. The technology reflects, with a reflector of the antenna system, the array element radiation pattern emitted from the phased array of elements to Earth, and establishes, based on a shape of the reflector, a predetermined magnification as a function of scan angle range so as to increase the field-of-view of the antenna system. The technology adjusts, based on the shape of the reflector, the array element radiation pattern, by increasing magnification relative to the scan angle range, to have a gain that increases with increases in scan angle relative to a boresight of the antenna system, and reflects, with the reflector, radiation from Earth to the phased array of elements.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.

Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.

Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

Abstract: A near-field test system for a phased array antenna includes a probe, a beam forming network, and a computing system. The probe is disposed at a fixed position in a near-field of the phased array antenna and transmits a test beam toward a fixed location on the phased array. The beam forming network is coupled to the phased array and includes a plurality of phase shifters and a beam summer. The phase shifters steer received beams for each antenna element of the phased array to form a planar wave front. The beam summer is coupled to the phase shifters and combines power of the received beams. The computing system is coupled to the beam forming network and scales combined power of the received beams and generates a virtual spectrum for the phased array antenna from scaled power of the received beams.