Patents by Inventor Paul Calabresi

Paul Calabresi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF TAUROLIDINE TO TREAT TUMORS
    Publication number: 20090163479
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: December 12, 2008
    Publication date: June 25, 2009
    Applicant: GEISTLICH PHARMA AG
    Inventors: Paul Calabresi, James Darnowski
  • Use of taurolidine to treat tumors
    Patent number: 7479505
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: January 20, 2009
    Assignee: Geistlich Phama AG
    Inventors: Paul Calabresi, James Darnowski
  • Methods of treating tumors
    Publication number: 20060135513
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 22, 2006
    Inventors: Paul Calabresi, James Darnowski
  • Methods of treating tumors
    Patent number: 6995164
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: February 7, 2006
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Use of a methylol-containing compound to treat tumors
    Patent number: 6964959
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing methylol-containing compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: November 15, 2005
    Assignees: Carter Wallace, Inc., Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski, James Costin
  • Taurine compounds
    Publication number: 20050065122
    Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to contact a tumor cell at a dose sufficient to induce cell death.
    Type: Application
    Filed: November 2, 2004
    Publication date: March 24, 2005
    Inventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
  • Combination drug therapy
    Patent number: 6849599
    Abstract: The invention provides antineoplastic composition containing an inhibitor of angiogenesis and an inhibitor of DNA topoisomerase type I enzyme activity.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: February 1, 2005
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Taurine compounds
    Patent number: 6812251
    Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 2, 2004
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
  • Use of taurolidine to treat tumors
    Publication number: 20040176360
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal by, administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: March 8, 2004
    Publication date: September 9, 2004
    Inventors: Paul Calabresi, James Darnowski
  • Use of taurolidine to treat tumors
    Patent number: 6703413
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: March 9, 2004
    Assignee: Rhode Island Hospital
    Inventors: Paul Calabresi, James Darnowski
  • Use of taurolidine to treat tumors
    Publication number: 20030100551
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: August 5, 2002
    Publication date: May 29, 2003
    Inventors: Paul Calabresi, James Darnowski
  • Methods of treating tumors
    Publication number: 20030078257
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: November 21, 2002
    Publication date: April 24, 2003
    Inventors: Paul Calabresi, James Darnowski
  • Methods of treating tumors with taurolidine
    Patent number: 6521616
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: February 18, 2003
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Taurine compounds
    Publication number: 20020183286
    Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death.
    Type: Application
    Filed: March 15, 2002
    Publication date: December 5, 2002
    Applicant: Rhode Island Hospital
    Inventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
  • USE OF TAUROLIDINE TO TREAT TUMORS
    Publication number: 20020111345
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: December 6, 2000
    Publication date: August 15, 2002
    Inventors: Paul Calabresi, James Darnowski
  • Combination drug therapy
    Publication number: 20020107191
    Abstract: The invention provides antineoplastic composition containing an inhibitor of angiogenesis and an inhibitor of DNA topoisomerase type I enzyme activity.
    Type: Application
    Filed: March 8, 2001
    Publication date: August 8, 2002
    Inventors: Paul Calabresi, James Darnowski
  • Use of taurolidine to treat tumors
    Patent number: 6429224
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: August 6, 2002
    Assignee: Rhode Island Hospital, A Lifespan Partner
    Inventors: Paul Calabresi, James Darnowski
  • Methods of treating tumors
    Publication number: 20020052366
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: December 6, 2000
    Publication date: May 2, 2002
    Inventors: Paul Calabresi, James Darnowski
  • Use of a methylol-containing compound to treat tumors
    Publication number: 20020049200
    Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing methylol-containing compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
    Type: Application
    Filed: December 6, 2000
    Publication date: April 25, 2002
    Inventors: Paul Calabresi, James Darnowski, James Costin
  • Drug cominbations containing AZT
    Patent number: 6365578
    Abstract: Combinations of 3′-azido-3′-deoxythymidine (AZT) with 5-fluorouracil (FUra) or its precursor 5-fluoro-2′-deoxyuridine (FUDR) or methoxtrexate (MTX) exhibit increased cytotoxicity and increased therapeutic index in treatment of carcinomas.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: April 2, 2002
    Assignee: Roger Williams General Hospital
    Inventors: Paul Calabresi, James W. Darnowski