Abstract: An electronic device includes a housing defining an internal volume, a front opening, and a rear opening. The electronic device can include a display component disposed at the front opening and a rear cover disposed at the rear opening. A logic board can be disposed in the internal volume. The device can also include a thin film thermopile including a cold junction bonded to the logic board and a hot junction bonded to the rear cover.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: Improved techniques for identifying objects, such as toy objects, are presented herein. In particular, a play system (e.g., game, doll playset, track set, etc.) includes a probed surface for use in obtaining electrical tomography measurements when toy objects are placed on the probed surface. The play system is configured to analyze the electrical tomography measurements to determine an identity of the toy object placed on the probed surface.

Abstract: Described are systems and methods which can be used to indicate the period of time elapsed since the occurrence of a triggering event. More particularly, this application relates to systems and methods which can be used to visually indicate the time period elapsed since an article has been removed from its packaging. The system can include an indicator disposed on or within the article and a trigger disposed within the receptacle and in contact with the indicator. The article may be enclosed within a sealable receptacle of the package. The indicator is responsive to a change in a concentration of the trigger in contact with the indicator.

Abstract: Disclosed herein relates to the biological activities and preparation of 5-(2-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-ol (Compound A) stable crystalline form (Compound A-Xln); its tablet (Compound A-Xln tablet); its phosphoric acid salt (Compound A-P) and phosphoric acid salt stable crystalline form (Compound A-P-Xln); as well as its enantiomers (Compound R-A, Compound S-A). Furthermore, their anti-cancer activities, stabilities, chirality, dissolutions and treatment indications have also been investigated.

Abstract: An adjustable dumbbell device includes a dumbbell having two weight ring supported on a receptacle, a handle having two end housings to be coupled to the weight rings, two weight members engageable into the housing, two spring biased catches engaged in the weight member, two arms coupled to the spring biased catches for moving the spring biased catches into and out of the weight members, a carrier slidably engaged in the receptacle and having a pole and a stud of different height for engaging with the arms and for actuating the arms to disengage the spring biased catches from the weight members, and an actuator moves the carrier relative to the receptacle to control an engagement of the pole and the stud with the arms.

Abstract: A weight member and the use in barbell and dumbbell devices are provided, wherein the weight member has a first side and a second side opposite to each other, and a split groove through the first side and the second side. A first mortise and a first tenon are arranged on the first side, and a second mortise and a second tenon are arranged on the second side. The first mortise and the second tenon are arranged in opposite direction correspondingly, and the first mortise and the second tenon are opposite to each other and arranged correspondingly. When the weight members are assembled together, the first mortise and the first tenon of one weight member is sliding interlocked with the second tenon and the second mortise of another weight member respectively.

Abstract: A composition for light filtering, the composition comprising: a base material; a plurality of nanoparticles dispersed in the base material, wherein the plurality of nanoparticles exhibit a peak light absorption value in the range of about 650 nm to about 800 nm; a chemical dye dispersed in the base material, the chemical dye having a spectral peak that is at least partially quenched by the filtering of the spectral curve of the nanoparticles; an anchoring mechanism dispersed in the base material, the anchoring mechanism comprising methacryloyl-derived monomer; and a nanoparticle coating material disposed on at least a portion of the plurality of nanoparticles.

Abstract: A composition for light filtering, the composition comprising: a base material comprising a HEMA-based material; a plurality of metal nanoparticles dispersed in the base material, wherein the plurality of metal nanoparticles exhibit a peak light absorption value in the range of about 500 nm to about 600 nm; an anchoring mechanism dispersed in the base material, the anchoring mechanism comprising methacryloyl-derived monomer; and a nanoparticle coating material disposed on at least a portion of the plurality of metal nanoparticles.

Abstract: Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

Abstract: Disclosed herein are compositions and methods comprising a composition for light filtering. An example composition comprises a plurality of metal nanoparticles, at least a portion of the plurality of metal nanoparticles having an anisotropic shape; and a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of metal nanoparticles, wherein the composition exhibits a peak light filtering value in the range of about 600 nm to about 850 nm.

Abstract: Disclosed are some implementations of systems, apparatus, methods and computer program products for processing consent information. A data consolidation system obtains, from each of two or more computing systems, a corresponding set of data objects such that two or more sets of objects are obtained. Each data object is associated with a corresponding individual and includes consent information indicating whether the individual consents to an action in relation to corresponding contact information of the individual. Consent information is extracted, for at least one individual, from the sets of data objects such that two or more sets of consent information are collected, the sets of consent information including a first set of consent information corresponding to a first computing system and a second set of consent information corresponding to a second computing system.

Abstract: A processor coupled to memory is configured to receive an identification of a geographical location associated with a target specified by a user remote from a vehicle. A machine learning model is utilized to generate a representation of at least a portion of an environment surrounding the vehicle using sensor data from one or more sensors of the vehicle. At least a portion of a path to a target location corresponding to the received geographical location is calculated using the generated representation of the at least portion of the environment surrounding the vehicle. At least one command is provided to automatically navigate the vehicle based on the determined path and updated sensor data from at least a portion of the one or more sensors of the vehicle.

Abstract: An adjustable dumbbell device includes one or more weight members and one or more weight elements each having two side panels to form a chamber, and an opening formed in each of the panels, two housings detachably engaged in the weight member and the weight element, two catches slidably engaged in each of the housings and engageable with the openings of the panels for anchoring the housings to the weight member and the weight element selectively, two followers are rotatably engaged in each of the housings and each include a gear engaged with the catches for moving the catches to engage with the panels and to anchor the housings to the weight member and the weight element respectively.

Abstract: An adjustable dumbbell device includes a dumbbell having two weight ring supported on a receptacle, a handle having two end housings to be coupled to the weight rings, two weight members engageable into the housing, two spring biased catches engaged in the weight member, two arms coupled to the spring biased catches for moving the spring biased catches into and out of the weight members, a carrier slidably engaged in the receptacle and having a pole and a stud of different height for engaging with the arms and for actuating the arms to disengage the spring biased catches from the weight members, and an actuator moves the carrier relative to the receptacle to control an engagement of the pole and the stud with the arms.

Abstract: A dumbbell and barbell supporting system includes two tables movable toward and away from each other and each having a plate, a casing and a bracket disposed on each of the plates and the bracket being movable and rotatable relative to the casing, two dumbbells disposed on the tables and each including two weight members and two weight elements disposed on the bracket and the casing, and two handlebars engageable with the weight members and the weight elements, the weigh members are movable toward each other, and the weight elements also movable toward each other, and a longitudinal bar is engageable with the weight members and the weight elements for acting as a barbell device.

Abstract: A processor coupled to memory is configured to receive an identification of a geographical location associated with a target specified by a user remote from a vehicle. A machine learning model is utilized to generate a representation of at least a portion of an environment surrounding the vehicle using sensor data from one or more sensors of the vehicle. At least a portion of a path to a target location corresponding to the received geographical location is calculated using the generated representation of the at least portion of the environment surrounding the vehicle. At least one command is provided to automatically navigate the vehicle based on the determined path and updated sensor data from at least a portion of the one or more sensors of the vehicle.

Abstract: An adjustable dumbbell device includes one or more weight members and one or more weight elements each having two side panels to form a chamber, and an opening formed in each of the panels, two housings detachably engaged in the weight member and the weight element, two catches slidably engaged in each of the housings and engageable with the openings of the panels for anchoring the housings to the weight member and the weight element selectively, two followers are rotatably engaged in each of the housings and each include a gear engaged with the catches for moving the catches to engage with the panels and to anchor the housings to the weight member and the weight element respectively.

Abstract: A dumbbell and barbell supporting system includes two tables movable toward and away from each other and each having a plate, a casing and a bracket disposed on each of the plates and the bracket being movable and rotatable relative to the casing, two dumbbells disposed on the tables and each including two weight members and two weight elements disposed on the bracket and the casing, and two handlebars engageable with the weight members and the weight elements, the weigh members are movable toward each other, and the weight elements also movable toward each other, and a longitudinal bar is engageable with the weight members and the weight elements for acting as a barbell device.